DNA adducts of styrene-7,8-oxide in target and non-target organs for tumor induction in rat and mouse after repeated inhalation exposure to styrene

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 500, Issue 1-2, 2002, Pages 111-116

  Otteneder, M ^a   Lutz, U ^a   Lutz, W K ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Biological markers; DNA adducts; Neoplasms; Predictive value

Indexed keywords

DNA; STYRENE; STYRENE OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CANCER INCIDENCE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CARCINOGENICITY; CELL SPECIFICITY; CELL TYPE; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; FEMALE; LIVER; LUNG CARCINOMA; MALE; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; TARGET ORGAN; TISSUE HOMOGENATE; TUMOR PROMOTION;

EID: 0037139154     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00008-8     Document Type: Article

References (25)

1. Review of the metabolite fate of styrene
2. Review of styrene and styrene oxide long-term animal studies
3. Styrene production, use and human exposure
4. In vitro kinetics of styrene and styrene oxide metabolism in rat, mouse and human
5. Covalent binding of styrene to DNA in rat and mouse
6. Evidence for DNA and protein binding by styrene and styrene oxide
7. Chronic toxicity/oncogenicity study of styrene in CD-1 mice by inhalation exposure for 104 weeks
8. Chronic toxicity/oncogenicity study of styrene in CD rats by inhalation exposure for 104 weeks
9. Reaction products of styrene oxide with guanosine in aqueous media
10. Identification of alkylation products of styrene oxide in single- and double-stranded DNA
11. Formation of deaminated products in styrene oxide reactions with deoxycytidine
12. Adenine N3 is a main alkylation site of styrene oxide in double-stranded DNA
13. Adduct formation on DNA and haemoglobin in mice intraperitoneally administered with styrene
14. 32P-postlabelling
15. 32P-postlabeling of styrene oxide treated DNA
16. 6-2′-deoxyguanosine-3′-monophosphate adducts of styrene oxide
17. 6-position of guanine
18. 32P-postlabeling assay
19. DNA adducts in relation to lung tumor outcome are not markers of susceptibility following a single dose treatment of SWR, BALB/c and C57BL/6J mice with N-nitrosodiethylamine
20. Correlation of DNA adduct levels with tumor incidence: Carcinogenic potency of DNA adducts
21. Background DNA damage from endogenous and unavoidable exogenous carcinogens: A basis for spontaneous cancer incidence?
22. 32P-postlabelling/HPLC analysis of various styrene-induced DNA adducts in mice
23. Metabolism of styrene by mouse and rat isolated lung cells
24. 14C-styrene by nose-only inhalation
25. Styrene metabolism in rats, mice and humans