Design, synthesis, and physicochemical and biological characterization of a new iron chelator of the family of hydroxychromenes

Journal of Medicinal Chemistry

Volumn 45, Issue 26, 2002, Pages 5776-5785

  Ferrali, Marco ^a   Bambagioni, Sabrina ^a   Ceccanti, Antonio ^a   Donati, Donato ^a   Giorgi, Giancola ^a   Fontani, Marco ^a   Laschi, Franco ^a   Zanello, Piero ^a   Casolaro, Mario ^a   Pietrangelou, Antonello ^b  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMENE DERIVATIVE; HYDROXYCHROMENE; IRON CHELATING AGENT; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COMPLEX FORMATION; DNA DAMAGE; DRUG DESIGN; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; GEOMETRY; HEMOCHROMATOSIS; IRON CHELATION; IRON OVERLOAD; LIPID PEROXIDATION; MASS SPECTROMETRY; OXIDATION REDUCTION REACTION; PHYSICAL CHEMISTRY; POTENTIOMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; TISSUE INJURY; X RAY DIFFRACTION;

ANIMALS; BENZOPYRANS; CHROMONES; CRYSTALLOGRAPHY, X-RAY; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE SPECTROSCOPY; FERRIC COMPOUNDS; HYDROGEN PEROXIDE; IRON CHELATING AGENTS; LIPID PEROXIDATION; MICROSOMES, LIVER; POTENTIOMETRY; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0037137604     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm021022u     Document Type: Article

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