Oral pristinamycin versus standard penicillin regimen to treat erysipelas in adults: Randomised, non-inferiority, open trial

British Medical Journal

Volumn 325, Issue 7369, 2002, Pages 864-866

  Bernard, Philippe ^a   Chosidow, Olivier ^b   Vaillant, Loïc ^c  

^a SERVICE DE DERMATOLOGIE   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c SERVICE DE DERMATOLOGIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PENICILLIN G; PRISTINAMYCIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; ERYSIPELAS; ERYTHEMA MULTIFORME; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VOMITING;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CASE-CONTROL STUDIES; ERYSIPELAS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PENICILLINS; PRISTINAMYCIN; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 0037137049     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Bernard P, Bedane C, Mounier M, Denis F, Catanzano G, Bonnetblanc JM. Streptococcal cause of erysipelas and cellulitis in adults: A microbiologic study. Arch Dermatol 1989;195:779-82
2. Duvanel T, Auckenthaler R, Rohner P, Harms M, Saurat JH. Quantitative cultures of biopsy specimens from cutaneous cellulitis. Arch Intern Med 1989;149:293-6.
3. Chartier C, Grossbans E. Erysipelas. Int J Dermatol 1990;29:459-67.
4. Swartz MN. Cellulitis and subcutaneous tissue infections. In: Mandell GL, Bennett JE, Dolin R. eds. Principles and practice of infectious diseases. New York: Churchill Livingstone 1995;909-15.
5. Bisno AL, Stevens DL. Streptococcal infections of the skin and soft tissues. N Engl J Med 1996;334:240-3.
6. Dupuy A, Benchikhi H, Roujeau JC, Bernard P, Vaillant L, Chosidow O, et al. Risk factors for erysipelas of the leg (cellulitis): Case-control study. BMJ 1999;318:1591-4.
7. Jorup-Rönström C. Epidemiological, bacteriological and complicating features of erysipelas Scand J Infect Dis 1986;18:519-24.
8. Chartier C, Grosshans E. Erysipelas: An update. Int J Dermatol 1996;35:779-81.
9. Ronnen P, Suster S, Schewach-Millet M, Modan M. Erysipelas: Changing faces. Int J Dermatol 1985;24:169-72.
10. Jorup-Rönström C, Britton S, Gavlevick A, Gunnarson AC. The course, costs and complications of oral versus intravenous penicillin therapy of erysipelas. Infection 1984;12:390-4.
11. Schmit JL. Enquête prospective. Erysipèle et cellulites nécrosan tes: Quelle prise en charge en milieu hospitalier? Ann Dermatol Vénéréol 2001;128:334-7.
12. Bernard P, Plantin P, Roger H, Sassolas B, Villaret E, Legrain V, et al. Roxithromycin versus penicillin in the treatment of erysipelas in adults: A comparative study. Br J Dermatol 1992;127:155-9.
13. Committee for Proprietary Medicinal Products, European Agency for the Evaluation of Medicinal Products. Points to consider on switching between superiority and non-inferiority. London: EAEMP, 2000 (CPMP/EWP/482/99.)
14. Bergkvist PI, Sjöbeck K, Antibiotic and prednisolone therapy of erysipelas: A randomised, double-blind, placebo-controlled study. Scand J Infect Dis 1997;29:377-8.
15. Erysipèle et fasciite nécrosante: Prise eni charge. Conférence de consensus. Ann Dermatol Vénéréol 2000;127:1118-37.
16. Siegel JP. Equivalence and noninferiority trials. Am Heart J 2000;139(suppl):S167-70.
17. Jones B, Jarvis P, Lewis JA, Ebbutt AF. Trials to assess equivalence in medical research: Are they supported by the evidence? BMJ 1996;313:36-9.
18. Kopp M, Schmit JL Bernard P. Prise en charge (les dermobypodermites bacteriennes par les medecins généralistes: Enquête de pratique et étude prospective. Ann Dermatol Vénéréol 2001;128:338-44.
19. Bernard P, Vaillant L, Martin C. Beylot C, Quentin R. Touron D. Pristinamycine (Pyostacine 500) versus oxacilline dans le traitement des pyodermites superficielles: Résultats d'une étude randomisée multicentrique chez 293 malades ambulatoires. Ann Dermatol Vénéréol 1997;124:384-9.