Isothiazole dioxides: Synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 16, 2002, Pages 2217-2220

  Clerici, Francesca ^a   Gelmi, Maria Luisa ^a   Yokoyama, Kohei ^b,c   Pocar, Donato ^a   Van Voorhis, Wesley C ^b   Buckner, Frederick S ^b   Gelb, Michael H ^b,c  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOTHIAZOLE DERIVATIVE; FARNESYL TRANS TRANSFERASE; GERANYLGERANYLTRANSFERASE TYPE I; GERANYLGERANYLTRANSFERASE TYPE-I; THIAZOLE DERIVATIVE; TRANSFERASE;

AFRICAN TRYPANOSOMIASIS; ARTICLE; BLOOD FLOW; DRUG EFFECT; DRUG POTENCY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; TRYPANOSOMA BRUCEI; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; RAT; SYNTHESIS;

TRYPANOSOMA; TRYPANOSOMA BRUCEI;

ALKYL AND ARYL TRANSFERASES; ANIMALS; FARNESYLTRANSTRANSFERASE; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; RATS; THIAZOLES; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0037136025     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00338-4     Document Type: Article

References (11)