Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185erbB) tyrosine kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 16, 2002, Pages 2153-2157

  Sun, Li ^a   Cui, Jean ^a   Liang, Congxin ^a   Zhou, Yong ^a   Nematalla, Asaad ^a   Wang, Xueyan ^a   Chen, Hui ^a   Tang, Cho ^a   Wei, James ^a  

^a SUGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PHOSPHOTYROSINE; PYRIMIDINONE DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; KETONE DERIVATIVE; PROTEIN P185; PROTEIN TYROSINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; ANIMAL CELL; AUTOPHOSPHORYLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE NEU; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION;

DRUG DESIGN; ENZYME INHIBITORS; MOLECULAR STRUCTURE; PHOSPHORYLATION; PHOSPHOTYROSINE; PYRIMIDINONES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037136012     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00364-5     Document Type: Article

References (10)