Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene

Journal of Cell Biology

Volumn 158, Issue 4, 2002, Pages 719-729

  Edgar, J M ^a   Anderson, T J ^a   Dickinson, P J ^a   Barrie, J A ^a   McCulloch, M C ^a   Nave, K A ^b   Griffiths, I R ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Heterozygote; Mutation; Myelin protein; Oligodendrocyte; Proteolipid protein

Indexed keywords

PROTEOLIPID PROTEIN;

ANIMAL TISSUE; ARTICLE; BRAIN; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; GENE; GENE MUTATION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MOUSE; MYELINATION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; SPINAL CORD; X CHROMOSOME INACTIVATION;

ALLELES; ANIMALS; CELL COMMUNICATION; CELL DEATH; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; DNA-BINDING PROTEINS; MICE; MUTATION; MYELIN SHEATH; OLIGODENDROGLIA; PHENOTYPE; PROTEIN FOLDING; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0037135990     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200202124     Document Type: Article

References (49)

1. Control of oligodendrocyte number in the developing rat optic nerve
2. Axonal control of oligodendrocyte development
3. Cell death in the oligodendrocyte lineage
4. Expression of the jimpy gene in the spinal cords of heterozygous female mice. I. An early myelin deficit followed by compensation
5. Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice
6. Cell death in the oligodendrocyte lineage: A molecular perspective of life/death decisions in development and disease
7. Myelin mosaicism and brain plasticity in heterozygous females of a canine X-linked trait
8. Myelin mosaicism in female heterozygotes of canine shaking pup and myelin-deficient rat mutants
9. Development of myelin mosaicism in the optic nerve of hetetozygotes of the X-linked myelin-deficient (md) rat mutant
10. Rumpshaker: An X-linked mutation affecting CNS myelination. A study of the female heterozygote
11. Rumpshaker: An X-linked mutation causing hypomyelination. Developmental differences in myelination and glial cells between the optic nerve and spinal cord
12. Oligodendrocyte development and differentiation in the rumpshaker mutation
13. The molecular pathogenesis of Pelizaeus-Merzbacher disease
14. A cellular mechanism governing the severity of Pelizaeus-Merzbacher disease
15. Many naturally occurring mutations of myelin proteolipid protein impair its intracellular transport
16. Disrupted proteolipid protein trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher disease
17. Shaking pup: A disorder of central myelination in the spaniel dog. II. Ultrastructural observations on the white matter of cervical spinal cord
18. Expression of myelin protein genes in Schwann cells
19. Rumpshaker mouse: A new X-linked mutation affecting myelination: Evidence for a defect in PLP expression
20. Current concepts of PLP and its role in the nervous system
21. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
22. Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord
23. Monoclonal antibody O10 defines a conformationally sensitive cell-surface epitope of proteolipid protein (PLP): Evidence that PLP misfolding underlies dysmyelination in mutant mice
24. Fate of jimpy-type oligodendrocytes in jimpy heterozygote
25. Assembly of CNS myelin in the absence of proteolipid protein
26. Oligodendroglial cell death in jimpy mice: An explanation for the myelin deficit
27. The rumpshaker mutation in spastic paraplegia
28. The oligodendrocyte precursor cell in health and disease
29. Cycling cells in the adult rat neocortex preferentially generate oligodendroglia
30. Oligodendrocyte survival in Wallerian degeneration
31. Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy
32. Effect of optic nerve transection upon myelin protein gene expression by oligodendrocytes: Evidence for axonal influences on gene expression
33. Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin
34. + glial cells: A novel glial cell population in the adult brain
35. Normal temporal and spatial distribution of oligodendrocyte progenitors in the myelin-deficient (md) rat
36. Oligodendrocyte production and myelin recovery in heterozygous jimpy mice: An autoradiographic study
37. Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene
38. Novel exon 3B proteolipid protein gene mutation causing late-onset spastic paraplegia type 2 with variable penetrance in female family members
39. Oligodendrocytes in female carriers of the jimpy gene make more myelin than normal oligodendrocytes
40. Expression of mosaicism in females heterozygous for jimpy
41. The unlabelled antibody-enzyme method of immunocytochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes
42. Cell dispersion patterns in different cortical regions studied with an X-inactivated transgenic marker
43. The early phenotype associated with the jimpy mutation of the proteolipid protein gene
44. Immunocytochemical localization of Po protein in Golgi complex membranes and myelin of developing rat Schwann cells
45. Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse
46. A proteolipid protein-(PLP)-specific pre-mRNA contains intron 3 and is upregulated during myelination in the CNS
47. Mouse models of myelin diseases
48. The proteolipid protein gene and myelin disorders in man and animal models
49. Myelin proteolipid proteins promote the interaction of oligodendrocytes and axons