Aggregation properties of a novel class of cationic Gemini surfactants correlate with their efficiency as gene transfection agents

Langmuir

Volumn 18, Issue 6, 2002, Pages 2426-2429

  Jennings, Kevin H ^a   Marshall, Ian C B ^a   Wilkinson, Michael J ^a   Kremer, Andreas ^a   Kirby, Anthony J ^b   Camilleri, Patrick ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; DISSOLUTION; DNA; HYDROCARBONS; HYDROPHOBICITY; POSITIVE IONS; SYNTHESIS (CHEMICAL); TRANSMISSION ELECTRON MICROSCOPY;

GENE TRANSFECTION AGENTS;

SURFACE ACTIVE AGENTS;

EID: 0037133881     PISSN: 07437463     EISSN: None     Source Type: Journal    
DOI: 10.1021/la0110242     Document Type: Article

References (12)

1. Felgner, P.L.; Gadek, T.R.; Holm, M.; Roman, R.; Chan, H.W.; Northrop, J.P.; Ringold, G.M.; Danielsen, M. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. U.S.A. 1987, 84, 7413-7417.
2. Wang, C.Y.; Huang, L. Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes. Biochemistry 1989, 28, 9508-9514.
3. Feigner, J.H.; Kumar, R.; Sridhar, C.N.; Wheeler, C.J.; Tsai, Y.J.; Border, R.; Ramsey, P.; Martin, M.; Felgner, P.L. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J. Biol. Chem. 1994, 269, 2550-2561.
4. Lee, R.J.; Huang, L. Lipidic vector systems for gene transfer. Crit. Rev. Ther. Drug Carrier Syst. 1997, 14, 173-206.
5. Menger, F.M.; Littau, C.A. Gemini surfactants: Synthesis and properties. J. Am. Chem. Soc. 1991, 113, 1451-1452.
6. Rosen, M.J. Geminis: A new generation of surfactants. CHEMTECH 1993, 30-34.
7. Camilleri, P.; Kremer, A.; Edwards, A.; Jennings, K.; Jenkins, O.; Marshall, I.; McGregor, C.; Neville, W.; Rice, S.; Smith, R.; Wilkinson, M.; Kirby, A. A novel class of cationic gemini surfactants with efficient in vitro gene transfection properties. J. Chem. Soc., Chem. Commun. 2000, 1253-1254.
8. Miller, A.D. Cationic liposomes for gene therapy. Angew. Chem., Int. Ed. 1998, 37, 1768-1785.
9. Blessing, T.; Remy, J.S.; Behr, J.P. Monomolecular collapse of plasmid DNA into stable virus-like particles. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 1427-1431.
10. Jennings, K.; Marshall, I.; Birrell, H.; Edwards, A.; Haskins, N.; Sodermann, O.; Kirby, A.J.; Camilleri, P. The synthesis and aggregation properties of a novel anionic gemini surfactant. J. Chem. Soc., Chem. Commun. 1998, 1951-1952.
11. Talmon, Y. Transmission electron microscopy of complex fluids the state of the art. Ber. Bunsen-Ges. Phys. Chem. 1996, 100, 364-372.
12. Anchordoquy, T.J.; Girouard, L.G.; Carpenter, J.F.; Kroll, D.J. Stability of lipid/DNA complexes during agitation and freeze-thawing. J. Pharm. Sci. 1998, 87, 1046-1051.