Flunitrazepam-membrane non-specific binding and unbinding: Two pathways with different energy barriers

Biophysical Chemistry

Volumn 95, Issue 2, 2002, Pages 157-164

  García, Daniel A ^a   Perillo, María A ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Benzodiazepine; Membrane packing; Phosphatidylcholine monolayer; Release and penetration of flunitrazepam

Indexed keywords

DIPALMITOYLPHOSPHATIDYLCHOLINE; FLUNITRAZEPAM; WATER;

AIR; ARTICLE; ARTIFICIAL MEMBRANE; CHEMICAL STRUCTURE; COMPRESSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PENETRATION; DRUG RELEASE; ELASTICITY; ENERGY; LIQUID; MEMBRANE BINDING; PARTITION COEFFICIENT; PRESSURE; PRIORITY JOURNAL; SURFACE PROPERTY;

CHEMISTRY, PHYSICAL; FLUNITRAZEPAM; INDICATORS AND REAGENTS; MEMBRANES, ARTIFICIAL; SURFACE PROPERTIES; THERMODYNAMICS;

EID: 0037133354     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-4622(02)00004-2     Document Type: Article

References (21)

1. A comparison of the physical dependence inducing properties of flunitrazepam and diazepam
2. Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites
3. Hormonal regulation of peripheral-type benzodiazepine receptors
4. Partitioning of 1,4-benzodiazepines into natural membranes
5. A biophysical approach to the anti-excitotoxic action mechanism of some sphingolipid derivatives
6. Determination of the membrane-buffer partition coefficient of flunitrazepam, a lipophilic drug
7. Partitioning of local anesthetics into membranes: surface charge effects monitored by the phospholipid head-group
8. Partitioning of flunitrazepam into model membranes studied by temperature controlled gel filtration chromatography
9. Benzodiazepine localisation at the lipid-water interface: effect of membrane composition and drug chemical structure
10. Flunitrazepam induces geometrical changes at the lipid-water interface
11. Flunitrazepam partitioning into natural membranes increases surface curvature and alters cellular morphology
12. Intrinsic curvature in normal and inverted lipid structures and in membranes
13. Furosemida and DIDS penetration into Langmuir films of stearic acid. The influence of low ionic strength and pH
14. Molecular parameters of semisynthetic derivatives of gangliosides and sphingosine in monolayers at the air-water interface
15. Supramolecular events modulate flunitrazepam partitioning into natural and model membranes
16. Phase behavior and molecular interactions in mixtures of ceramide with dipalmitoylphosphatidylcholine
17. Interfacial interactions of ceramide with dimyristoylphosphatidylcholine: impact of the N-acyl chain
18. Differential partitioning of pulmonary surfactant protein SP-A into regions of monolayers of dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylcholine/dipalmitoylphosphatidylglycerol
19. Epifluorescence microscopic studies of monolayers containing mixtures of dioleoyl- and dipalmitoylphosphatidylcholines
20. Molecular chirality and domain shapes in lipid monolayers on aqueous surfaces