The use of polymer heteronuclei for crystalline polymorph selection

Journal of the American Chemical Society

Volumn 124, Issue 50, 2002, Pages 14834-14835

  Lang, Meidong ^a   Grzesiak, Adam L ^a   Matzger, Adam J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARACETAMOL; POLYMER;

ARTICLE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CRYSTALLIZATION;

EID: 0037132641     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0286526     Document Type: Article

References (21)

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9. Recently, these methods have been used in a high throughput manner: Peterson, M. L.; Morissette, S. L.; McNulty, C.; Goldsweig, A.; Shaw, P.; LeQuesne, M.; Monagle, J.; Encina, N.; Marchionna, J.; Johnson, A.; Gonzalez-Zugasti, J.; Lemmo, A. V.; Ellis, S. J.; Cima, M. J.; Almarsson, Ö. J. Am. Chem. Soc. 2002, 124, 10958-10959.
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19. Acetaminophen crystallization was carried out by the following procedure: A different polymer (3-10 mg, Scientific Polymer Products) was added into each well of a 96-well polypropylene plate. After adding 4.8 mg of acetaminophen and 0.3 mL of water, the plate was heated to 100 °C for 30 min with periodic addition of water to maintain volume. The plate was cooled to room temperature and loosely covered, allowing slow evaporation. Two crystal morphologies were observed. Powder X-ray diffraction showed that the prismatic crystals were monoclinic, while the elongated prisms were orthorhombic. Repeating this analysis in plates with no added polymer led exclusively to monoclinic acetaminophen. The reported results were collected from three separate plates to gauge reproducibility, and only the 84 polymers that consistently yielded orthorhombic, monoclinic, or a mixture of both polymorphs are reported.
20. 14 have had in repeating these results.
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