Direct synthesis of guanidines using di(imidazole-1-yl)methanimine

Journal of Organic Chemistry

Volumn 67, Issue 21, 2002, Pages 7553-7556

  Wu, Yong Qian ^a   Hamilton, Sean K ^a   Wilkinson, Douglas E ^a   Hamilton, Gregory S ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REAGENTS;

ORGANIC COMPOUNDS;

SYNTHESIS (CHEMICAL);

DI(IMIDAZOLE 1 YL)CYANOMETHANIMINE; DI(IMIDAZOLE 1 YL)METHANIMINE; DICYANODIAMIDE DERIVATIVE; GUANIDINE DERIVATIVE; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL BOND; CYCLIZATION; DRUG SYNTHESIS; POLYMERIZATION; REACTION ANALYSIS; SOLID; STRUCTURE ANALYSIS;

GUANIDINES; IMIDAZOLES; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLAMINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037131286     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0202381     Document Type: Article

References (10)

1. (a) The Pharmacological Basis of Therapeutics, 7th ed.; Gilman, A. G., Goodman, L. S., Rall, T. W., Murad, F., Eds.; Pergamon Press: New York, 1990; p 899.
2. (b) Hu, L. Y.; Guo, J.; Magar, S. S.; Fischer, J. B.; Burke-Howie, K. J.; Durant, G. J. J. Med. Chem. 1997, 40 (26), 4281-9.
3. Koert, U. et al. Tetrahedron 1999, 55 (10), 713.
4. Lipton, M. Tetrahedron Lett. 1999, 40, 53.
5. Katritzky, A. R.; Rogovoy, B. V.; Chassaing, C.; Vvedensky, V. J. Org. Chem. 2000, 65, 8080-8082.
6. Ferris, J. P.; Huang, C. H.; Hagan, W. J. Nucleosides Nucleotides 1989, 8 (3), 407-414.
7. Arndt, F. Ann. Chem. 1911, 384, 322.
8. Durant, G. J.; Emmett, J. C.; Ganellin, C. R.; Miles, P. D.; Parsons, M. E.; Prain, H. D.; White, G. R. J. Med. Chem. 1977, 20 (7), 901-906.
9. Atwal, K. S.; Ferrara, F. N.; Ahmed, S. Z. Tetrahedron Lett. 1994, 35, 8085-8088.
10. Wu, Y. Q.; Limburg, D.; Wilkinson, D. E.; Hamilton, G. S. J. Heterocycl. Chem., submitted.