Antihyperalgesia effect of BmK AS, a scorpion toxin, in rat by intraplantar injection

Brain Research

Volumn 952, Issue 2, 2002, Pages 322-326

  Chen, Bing ^a   Ji, Yonghua ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

Antihyperalgesia; BmK AS; Buthus martensi Karsch; Paw withdrawal latency; Voltage gated sodium channel

Indexed keywords

CARRAGEENAN; SCORPION VENOM; SODIUM CHANNEL; SODIUM CHANNEL AFFECTING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; HYPERALGESIA; INFLAMMATION; LATENT PERIOD; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SCORPION; WITHDRAWAL REFLEX;

ANALGESICS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAT; HINDLIMB; HYPERALGESIA; INJECTIONS, SUBCUTANEOUS; MALE; PAIN MEASUREMENT; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; SCORPION VENOMS;

EID: 0037131065     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03241-9     Document Type: Article

References (24)

1. Andrew D., Greenspan J.D. Mechanical and heat sensitization of cutaneous nociceptors after peripheral inflammation in the rat. J. Neurophysiol. 82:1999;2649-2656.
2. + channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy. Proc. Natl. Acad. Sci. USA. 95:1998;8963-8968.
3. Elliott A.A., Elliott J.R. Characterization of TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. J. Physiol. (London). 463:1993;39-56.
4. + current in nociceptors. Proc. Natl. Acad. Sci. USA. 93:1996;1108-1112.
5. Gordon D., Savarin P., Gurevitz M., Zinn-Justin S. Functional anatomy of scorpion toxins affecting sodium channels. J. Toxicol. Toxin Rev. 17:1998;131-159.
6. Hargreaves K.M., Dubner R., Brown F., Flores C., Joris J. A new and sensitive method for measuring the thermal nociception in cutaneous hyperalgesia. Pain. 32:1998;77-88.
7. Ji Y.H., Mansuelle P., Terakawa S., Kopeyan C., Yanaihara N., Xu K., Rochat H. Two neurotoxins (BmK I and BmK II) from the venom of scorpion Buthus martensi Karch: purification, amino acids sequences and assessment of specific activity. Toxicon. 34:1996;987-1001.
8. 3H]noradrenaline release from rat hippocampal slices. Biomed. Res. 3:1997;257-260.
9. Ji Y.H., Li Y.J., Zhang J.W., Song B.L., Yamaki T., Mochizuki T., Hoshino M., Yanaihara N. Covalent structures of BmK AS and BmK AS-1, two novel bioactive polypeptides purified from Chinese scorpion Buthus martensi Karsch. Toxicon. 37:1999;519-536.
10. Kharrart R., Darbon T., Granier C., Rochat H. Structure-activity relationship of scorpion α-neurotoxins: contribution of arginine residues. Toxicon. 28:1990;509-523.
11. 2+-release channel activity of the skeletal-muscle ryanodine receptor by an indirect mechanism. Biochem. J. 339:1999;343-350.
12. Levine J.D., Reichling D.B. Peripheral mechanisms of inflammatory pain. Wall P.D., Melzack R., Textbook of Pain. 1999;59-61 Churchill Livingstone, Edinburgh.
13. Li Y.J., Liu Y., Ji Y.H. BmK AS: new scorpion neurotoxin binds to distinct receptor sites of mammal and insect voltage-gated sodium channels. J. Neurosci. Res. 61:2000;541-548.
14. Liu Y., Ren H.M., Ohishi T., Mochizuki T., Hoshino M., Yanaihare N. Purification and the partial amino acid sequence of a novel activation of ryanodine receptor (BmK AS-1) from mammalian skeletal muscle. Biomed. Res. 6:1996;451-455.
15. +-channels. Eur. J. Biochem. 264:1999;287-300.
16. Rechthand E., Rapoport S.I. Regulation of the microenvironment of peripheral nerve: role of the blood-nerve barrier. Prog. Neurobiol. 28:1987;303-343.
17. Ren K., Dubner R. Enhanced descending modulation of nociception in rat with persistent hindpaw inflammation. J. Neurophysiol. 28:1996;3025-3037.
18. Srdija J. The role of tetrodotoxin-resistant sodium channel of small primary afferent fibers. Brain Res. 430:1994;315-335.
19. Taiwo Y.O., Levine J.D. Prostaglandin effects after elimination of indirect hyperalgesic mechanisms in the skin of the rat. Brian Res. 492:1989;397-399.
20. + current in dorsal root ganglion neurons. Neurosci. Lett. 297:2001;65-68.
21. + channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model. Neuroreport. 9:1998;653-655.
22. 2, a depressant insect-selective scorpion toxin in rat by peripheral administration. Brain Res. Bull. 51:2000;335-338.
23. Wu Y., Ji Y.H., Shi Y.L. Sodium current in NG108-15 cell inhibited by scorpion BmK AS-1 and restored by its specific monoclonal antibodies. J. Nat. Toxins. 10:2001;193-198.
24. Zimmermann Z. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;119-120.