A Trypanosoma cruzi small surface molecule provides the first immunological evidence that Chagas' disease is due to a single parasite lineage

Journal of Experimental Medicine

Volumn 195, Issue 4, 2002, Pages 401-413

  Di Noia, Javier M ^a   Buscaglia, Carlos A ^a,c   De Marchi, Claudia R ^b   Almeida, Igor C ^b   Frasch, Alberto C C ^a  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

Author keywords

Chagas' disease; Lineage dimorphism; Mucin like; Serodiagnosis; Trypanosoma cruzi

Indexed keywords

ANTIGENICITY; ARTICLE; CELL SURFACE; CHAGAS DISEASE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC LINE; HUMAN; MAJOR CLINICAL STUDY; PARASITE IDENTIFICATION; PRIORITY JOURNAL; SERODIAGNOSIS; TRYPANOSOMA CRUZI;

EID: 0037128161     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011433     Document Type: Article

References (46)

1. The life cycle of Trypanosoma cruzi revisited
2. Chagas disease: Recombinant Trypanosoma cruzi antigens for serological diagnosis
3. Genetic variability of Trypanosoma cruzi: Implications for the pathogenesis of Chagas' disease
4. DNA markers define two phylogenetic lineages of Trypanosoma cruzi
5. Epidemiology, biochemistry and evolution of Trypanosoma cruzi lineages based on ribosomal RNA sequences
6. Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi
7. Maximum-likelihood divergence date estimates based on rRNA gene sequences suggest two scenarios of Trypanosoma cruzi intraspecific evolution
8. The evolution of two Trypanosoma cruzi subgroups inferred from rRNA genes can be correlated with the interchange of American mammalian faunas in the Cenozoic and has implications to pathogenicity and host specificity
9. Natural populations of Trypanosoma cruzi, the agent of Chagas disease, have a complex multiclonal structure
10. Isozymic heterogeneity of Trypanosoma cruzi in the first autochthonous patients with Chagas' disease in Amazonian Brazil
11. Trypanosoma cruzi strains partition into two groups based on the structure and function of the spliced leader RNA and rRNA gene promoters
12. Probing the genetic population structure of Trypanosoma cruzi with polymorphic microsatellites
13. Host specificity of ribosomal DNA variation in sylvatic Trypanosoma cruzi from North America
14. The protozoan Trypanosoma cruzi has a family of genes resembling the mucin genes of mammalian cells
15. Two distinct groups of mucin-like genes are differentially expressed in the developmental stages of Trypanosoma cruzi
16. The Trypanosoma cruzi mucin family is transcribed from hundreds of genes having hypervariable regions
17. A random sequencing approach for the analysis of the Trypanosoma cruzi genome: General structure, large gene and repetitive DNA families, and gene discovery
18. Trypanosoma cruzi surface mucins with exposed variant epitopes
19. Mucin gene structure and expression: Protection vs. adhesion
20. Biological parameters and molecular markers of clone CL Brener: The reference organism of the Trypanosoma cruzi genome project
21. Rapid evolution of kinetoplast DNA mini-circle subpopulations in Trypanosoma cruzi
22. Trypanosoma cruzi: Biological characterization of 19 clones derived from two chronic chagasic patients. I. Growth kinetics in liquid medium
23. High diversity in mucin genes and mucin molecules in Trypanosoma cruzi
24. A highly sensitive and specific chemiluminescent enzyme-linked immunosorbent assay for diagnosis of active Trypanosoma cruzi infection
25. Hemoculture: Sensitive technique in the detection of Trypanosoma cruzi in chagasic patients in the chronic phase of Chagas disease
26. Chemiluminescent immunoassays: Discrimination between the reactivities of natural and human patient antibodies with antigens from eukaryotic pathogens, Trypanosoma cruzi and Paracoccidioides brasiliensis
27. Simultaneous multiple peptide synthesis under continuous flow conditions on cellulose paper discs as segmental solid synthesis
28. Antibodies
29. Predicting subcellular localization of proteins based on their N-terminal amino acid sequence
30. O-GLYCBASE version 4.0: A revised database of O-glycosylated proteins
31. Mapping the Trypanosoma cruzi genome: Analyses of representative cosmid libraries
32. Mechanisms of stage-regulated gene expression in Kinetoplastida
33. Control of gene expression in trypanosomes
34. Stage-regulated expression of cruzipain, the major cysteine protease of Trypanosoma cruzi is independent of the level of RNA1
35. AU-rich elements in the 3′-untranslated region of a new mucin-type gene family of Trypanosoma cruzi confers mRNA instability and modulates translation efficiency
36. Functionally different AU- and G-rich cis-elements confer developmentally regulated mRNA stability in Trypanosoma cruzi by interaction with specific RNA-binding proteins
37. The complete sequence of a shed acute-phase antigen of Trypanosoma cruzi
38. Evaluation of recombinant antigens for serodiagnosis of Chagas' disease in South and Central America
39. Heterologous expression of a Trypanosoma cruzi surface glycoprotein (gp82) indicates that requirements for glycosylphosphatidylinositol anchoring are different in mammalian cells and this trypanosome
40. Requirements for glycosylphosphatidylinositol attachment are similar but not identical in mammalian cells and parasitic protozoa
41. GPI-anchored proteins: Now you see 'em, now you don't
42. Mucin-like glycoproteins linked to the membrane by glycosylphosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalyzed by trans-sialidase in metacyclic forms of Trypanosoma cruzi
43. Lytic anti-alpha-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi
44. Genetic characterization of Trypanosoma cruzi directly from tissues of patients with chronic Chagas disease: Differential distribution of genetic types into diverse organs
45. Sequence of the 24S alpha ribosomal RNA gene and characterization of a corresponding pseudogene from Trypanosoma cruzi