2,5′-disubstituted adenosine derivatives: Evaluation of selectivity and efficacy for the adenosine A1, A2A, and A3 receptor

Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2002, Pages 420-429

  Van Tilburg, Erica W ^a   Von Frijtag Drabbe Künzel, Jacobien ^a   De Groote, Miriam ^a   IJzerman, Ad P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 HEXYNYL) 5' S ISOPROPYL 5' THIOADENOSINE; 2 (1 HEXYNYL) 5' S METHYL 5' THIOADENOSINE; 2 (1 HEXYNYL) 5' S PROPYL 5' THIOADENOSINE; 2 (1 HEXYNYL)ADENOSINE; 2 (N' 3 METHYL 1 BUTYLIDENEHYDRAZINO) 5' S ISOPROPYL 5' THIOADENOSINE; 2 (N' 3 METHYL 1 BUTYLIDENEHYDRAZINO) 5' S METHYL 5' THIOADENOSINE; 2 (N' 3 METHYL 1 BUTYLIDENEHYDRAZINO) 5' S PROPYL 5' THIOADENOSINE; 2 IODO 5' S PROPYL 5' THIOADENOSINE; 5' S ETHYL 2 (1 HEXYNYL) 5' THIOADENOSINE; 5' S ETHYL 2 (N' 3 METHYL 1 BUTYLIDENEHYDRAZINO) 5' THIOADENOSINE; 5' S ETHYL 2 IODO 5' THIOADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DERIVATIVE; CYCLIC AMP; GUANOSINE; UNCLASSIFIED DRUG; ADENOSINE; ADENOSINE RECEPTOR; DRUG DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; ANIMAL; BIOSYNTHESIS; BRAIN; CELL LINE; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; HAMSTER; HUMAN; IN VITRO STUDY; METABOLISM; RADIOASSAY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADENOSINE; ANIMALS; BRAIN; CELL LINE; CRICETINAE; CYCLIC AMP; HUMANS; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037122456     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010952v     Document Type: Article

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