An efficient one-pot enantio- and diastereoselective synthesis of heterocycles

Angewandte Chemie - International Edition

Volumn 41, Issue 24, 2002, Pages 4693-4697

  Trost, Barry M ^a   Machacek, Michelle R ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Alkylation; Asymmetric synthesis; Heterocycles; Homogeneous catalysis; Palladium; Ruthenium

Indexed keywords

ALKYLATION; CATALYSTS; NITROGEN; OXYGEN; SUBSTRATES; SYNTHESIS (CHEMICAL);

HETEROCYCLES;

STEREOCHEMISTRY;

HETEROCYCLIC COMPOUND; NITROGEN; OXYGEN; PALLADIUM;

ALKYLATION; ARTICLE; CATALYSIS; CATALYST; CHEMICAL PROCEDURES; CHEMICAL STRUCTURE; CHEMISTRY; CHIRALITY; ENANTIOSELECTIVITY; PRECURSOR; STEREOCHEMISTRY; STEREOISOMERISM; SYNTHESIS;

HETEROCYCLIC COMPOUNDS; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 0037122149     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200290019     Document Type: Article

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29. This compound has been fully characterized by spectroscopic methods and the elemental composition has been established by high-resolution mass spectrometry and/or combustion analysis.
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37. The assignment of relative configuration was straightforward by NMR spectroscopy. Since the absolute stereochemistry of the starting substrate is known, the absolute configuration of the newly created allylic stereogenic center is also known. These stereochemical assignments are furthermore consistent with our mnemonic and with those made in Table 1.