A study of some indirect biochemical markers in the evaluation of enzymatic induction caused by antiepileptic drugs;Estudio de algunos marcadores bioquímicos indirectos en la evaluación de la inducción enzimática por fármacos antiepilépticos

Revista de Neurologia

Volumn 35, Issue 8, 2002, Pages 711-716

  Tutor Crespo, M J ^a   Hermida Almeijeiras, J ^a   Tutor Valcarce, J Carlos ^a  

^a Instituto de Salud Carlos III   (Spain)

Author keywords

Antiepileptic drugs; Bilirubin; D glucaric acid; Enzymatic forms; Enzymatic induction; Glutamyltransferase

Indexed keywords

ANTICONVULSIVE AGENT; BIOCHEMICAL MARKER; CARBAMAZEPINE; GAMMA GLUTAMYLTRANSFERASE; PHENOBARBITAL; PHENYTOIN; SACCHARIC ACID; VALPROIC ACID;

ADULT; ARTICLE; BILIRUBIN BLOOD LEVEL; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; SCORING SYSTEM; URINARY EXCRETION;

EID: 0037121154     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.3508.2002250     Document Type: Article

References (41)

1. Gorrod JW, Beckett AH. Drug metabolism in man. London: Taylor and Francis Ltd.; 1978.
2. Johnson MD, Newkirk G, White JR. Clinically significant drug interactions. Postgrad Med 1999; 105: 193-222.
3. Miguet JP, Allemand H, Vuiton D. Les tests in vivo d'induction enzimatique medicamentense chez l'homme. Gastroenterol Clin Biol 1981; 5: 798-811.
4. Park BK, Kintteringham NR. Relevance and means of assessing induction and inhibition of drug metabolism in man. In Gibson GG, ed. Progressing drug metabolism. New York: Taylor and Francis Ltd.; 1988. p. 1-60.
5. Siest G, Batt AM, Galteau MM. Les examens biologiques temoins indirects de l'activité des enzymes du métabolisme des medicaments. Ann Biol Clin 1977; 35: 425-32.
6. Batt AM, Siest G, Magdalou J, Galteau MM. Enzyme induction by drugs and toxins. Clin Chim Acta 1992; 209: 109-21.
7. Davis M, Labadarios D. Urinary D-glucaric acid excretion and screening for enzyme induction. In Richens A, Woodford FP, eds. Anticonvulsant drugs and enzyme induction. Amsterdam: Associated Scientific Publishers; 1976. p. 13-25.
8. Scott AK, Jeffers TA, Petrie JC, Gilbert JC. Serum bilirubin and hepatic enzyme induction. Br Med J 1979; 2: 310.
9. Gough G, Goggin T, Crowley M, Callaghan C. Serum bilirubin levels with antiepileptic drugs. Epilepsia 1999; 30: 597-602.
10. Rosalki SB. Plasma enzyme changes and their interpretation in patients receiving anticonvulsant and enzyme-inducing drugs. In Richens A, Woodford FP, eds. Anticonvulsant drugs and enzyme induction. Amsterdam: Associated Scientific Publishers; 1976. p. 27-35.
11. Fernández MP, Tutor JC, Paz JM. Determinación del ácido D-glucárico urinario por un procedimiento enzimático. Clin Chem Newsletter 1982; 2: 77-81.
12. Makki KA, Beetham R, Richens A. Overnight urine specimens for the determination of D-glucaric acid excretion in man. Br J Clin Pharmacol 1979; 8: 183-6.
13. Kok PJMJ, Seidel B, Holtkamp HC, Huisman J. A new procedure for the visualization of multiple forms of gamma-glutamyltransferase. Clin Chim Acta 1978; 90: 209-16.
14. Beck PR. Butanol extraction of serum and urinary gamma-glutamyltransferase. In Goldberg DM, Wilkinson SH, eds. Enzymes in health and disease. Basel: Karger; 1978. p. 137-9.
15. Beck PR. Butanol extraction of serum and urinary gamma-glutamyltransferase and its application in clinical diagnosis. Ann Clin Biochem 1978; 15: 151-6.
16. Doumas BI, Perry BW, Sasse EA. Standardization of bilirubin assays. Evaluation of selected methods and stability of bilirubin solutions. Clin Chem 1973; 19: 984-93.
17. Fishman VH, Kato K, Austiss CC. Human serum β-glucuronidase. Its measurement and some of its properties. Clin Chim Acta 1967; 15: 435-42.
18. Adin J, Gutiérrez-Rubio F, Armijo JA. Antiepilépticos e hígado. Rev Neurol 2000; 30 (Supl 1): S94-104.
19. Price DE, Mehta A, Park BK, Hay A, Feely MP. The effect of low-dose phenobarbitona on three indices of hepatic microsomal enzyme induction. Br J Clin Pharmacol 1986; 22: 744-7.
20. Salas-Puig J. Politerapia antiepiléptica racional. Interacciones medica-mentosas y elección del tratamiento. Rev Neurol 2000; 30: 886-9.
21. Oxley J, Hedges A, Makki KA, Monks A, Richens A. Lack of hepatic enzyme inducing effect of sodium valproate. Br J Clin Pharmacol 1979; 8: 189-90.
22. Kunimasa T, Sumitani A, Yamashita S. Sex differences in serum gamma-glutamyltransferase. Jpn J Gastroenterol 1979; 76: 1802-8.
23. Frezza M, Parco S, Piccinini C, Tiribelli C, Pozzato G. Gamma-glutamyltranspeptidase and estrogen hormones. Gastroenterology 1978; 74: 800-3.
24. Pozzato G, Chiesa L, Parco S, Tamaro G, Magiarotti MA, Frezza M. Total serum GGT and its isoenzymes inhibition after esoestrol administration in normal, alcoholist and patients with obstructive jaudince. Lab J Res Med 1984; 11: 355-8.
25. King J, Beck PR. Fractionation studies with serum and urinary gamma-glutamyltransferase. In Burlina A, Calcigna L, eds. Clinical enzymology symposia 2. Padua: Piccin Medical Books; 1979. p. 55-76.
26. Sacchetti L, Castaldo G, Salvatore F. Electrophoretic behaviour an partial characterization of disease-associated serum forms of gamma-glutamyltansferase. Electrophoresis 1989; 10: 619-27.
27. Huseby NE. Multiple forms of serum gamma-glutamyltransferase. Association of the enzyme with lipoproteins. Clin Chim Acta 1982; 124: 103-12.
28. Sacchetti L, Castaldo G, Fortunato G, Salvatore F. Improved procedure for measuring gamma-glutamyltransferase isoenzymes in serum. Clin Chem 1988; 34: 419-22.
29. Artur Y, Wellman-Bednawska M, Jacquier A, Siest G. Complexes of serum gamma-glutamyltransferase with apolipoproteins and immunoglobulins. Clin Chem 1984; 30: 631-3.
30. Selvaraj P, Rolston DDK, Balasubramanian KA. Separation of hydrophobic and hydrophilic forms of γ-glutamyltransferase from human serum by hydrophobic chromatography on phenylsepharose CL-4B. Clin Chim Acta 1984; 138: 141-9.
31. Novo FJ, Louro MO, Tutor JC. Multiple forms of serum 5′-nucleotidase in patients receiving anticonvulsant enzymenducing drugs. L'Eurobiologiste (Paris) 1994; 28: 363-8.
32. Nemesánszky E, Lott JA. Gamma-glutamyltransferase and its isoenzymes. Progress and problems. Clin Chem 1985; 31: 797-803.
33. Perucca E, Hedges A, Makki KA, Wadsworth J, Richens A. The comparative enzyme-inducing properties of antiepileptic drugs. Br J Clin Pharmacol 1979; 7: 414-5.
34. Perucca E, Hedges A, Makki KA, Ruprah M, Wilson JF, Richens A. A comparative study of the relative enzyme-inducing properties of anticonvulsant drugs. Br J Clin Pharmacol 1984; 18: 401-10.
35. Richens A, Rowe DJF. Disturbance of calcium metabolism by anticonvulsant drugs. Br Med J 1970; 4: 73-6.
36. Hunter J, Maxwell JD, Carrella M, Stewart DA. Urinary D-glucaric acid excretion as a test for hepatic enzyme induction in man. Lancet 1971; 1: 572-5.
37. Hermida J, Fernández MP, Tutor JC. Relationship between changes in drug score, D-glucaric acid excretion, and γ-glutamyltransferase and β-glucuronidase serum activities during anticonvulsant treatment. Clin Lab 2002; 48: 415-9.
38. Bagrel D, Bagrel A, Le Perron B, Siest G. Effects of antiepileptic drugs on laboratory tests. In Siest G, ed. Drug effects on laboratory test results. The Hague: Martinus Nijhoft Publishers; 1980. p. 261-73.
39. Tutor JC, Fernández MP, Paz JM. Actividad sérica de la β-glucuronidasa en pacientes tratados con fenobarbital y difenilhidantoína. Arch Farmacol Toxicol 1982; 8: 37-44.
40. Batt A, Siest G, Magdalou J, Galteau MM. Enzyme induction by drugs and toxins. Clin Chim Acta 1992; 209: 109-21.
41. Low LK, Castagnoli N. Drugs biotransformations. In Wolf ME, ed. The basis of medicinal chemistry. 4 ed. New York: John Wiley and Sons; 1980, p. 107-226.