Etiology of the mutational spectrum of ras genes in human carcinomas

Journal of the National Cancer Institute

Volumn 94, Issue 20, 2002, Pages 1516-1517

  Kelley, Michael J ^a,b   Littman, Susan J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA BASE; NUCLEOTIDE; PROTEIN P53;

BEHAVIOR; CANCER RISK; CARCINOGEN DNA INTERACTION; CARCINOGENESIS; CHROMOSOME REARRANGEMENT; CODON; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; DNA STRUCTURE; DRUG TARGETING; EDITORIAL; GENE AMPLIFICATION; GENE DELETION; GENE MUTATION; HUMAN; LUNG CANCER; MUTAGENESIS; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE N RAS; ONCOGENE RAS; POINT MUTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOKING; SPECIES DIFFERENCE;

EID: 0037120953     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/94.20.1516     Document Type: Editorial

References (9)

1. Hecht SS: Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 1999;91:1194-210.
2. Kelley MJ, Johnson BE. Molecular biology of lung cancer. In: Mendelsohn J, Howley PM, Israel MA, Liotta LA, editors. Molecular basis of cancer. 2nd ed. Philadelphia (PA): W. B. Saunders; 2001. p. 260-87.
3. Feng Z, Hu W, Chen JX, Pao A, Li H, Rom W, et al. Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. J Natl Cancer Inst 2002;94:1527-36.
4. Tretyakova N, Matter B, Jones R, Shallop A. Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach. Biochemistry 2002;41:9535-44.
5. Denissenko MF, Chen JX, Tang MS, Pfeifer GP. Cytosine methylation determines hot spots of DNA damage in the human P53 gene. Proc Natl Acad Sci U S A 1997;94:3893-8.
6. Cloutier JF, Drouin R, Castonguay A. Treatment of human cells with N-nitroso(acetoxymethyl)methylamine: distribution patterns of piperidine-sensitive DNA damage at the nucleotide level of resolution are related to the sequence context. Chem Res Toxicol 1999:12:840-9.
7. Lippman SM, Spitz MR. Lung cancer chemoprevention: an integrated approach. J Clin Oncol 2001 19(18 Suppl):74S-82S.
8. Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, Iacopetta, BJ, et al. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer 2001;85:692-6.
9. Shields JM, Pruitt K, McFall A, Shaub A, Der CJ. Understanding Ras: 'it ain't over 'til it's over'. Trends Cell Biol 2000;10:147-54.