Oligonucleotides comprised of alternating 2′-Deoxy-2′-fluoro-β-D-arabinonucleosides and D-2′-deoxyribonucleosides (2′F-ANA/DNA 'Altimers') induce efficient RNA cleavage mediated by RNase H

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 18, 2002, Pages 2651-2654

  Min, Kyung Lyum ^a   Viazovkina, Ekaterina ^a   Galarneau, Annie ^a   Parniak, Michael A ^a   Damha, Masad J ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXY 2' FLUORO DEXTRO ARABINONUCLEIC ACID; ARABINONUCLEOSIDE; COMPLEMENTARY RNA; DEOXYRIBONUCLEOSIDE; DNA; OLIGOMER; OLIGONUCLEOTIDE; RIBONUCLEASE H; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME DEGRADATION; RNA CLEAVAGE;

ARABINONUCLEOSIDES; HYDROLYSIS; OLIGONUCLEOTIDES, ANTISENSE; RIBONUCLEASE H, CALF THYMUS; RNA;

ESCHERICHIA COLI;

EID: 0037119693     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00439-0     Document Type: Article

References (21)

1. Walder R.Y., Walder J.A. Proc. Natl. Acad. Sci. U.S.A. 85:1988;5011.
2. Zamecnik P.C., Stephenson M.L. Proc. Natl. Acad. Sci. U.S.A. 75:1978;280.
3. (a) Wagner R.W. Nature. 372:1994;333.
4. (b) Wagner R.W. Antisense Res. Dev. 5:1995;113.
5. Matteucci M., Wagner R. Nature. 384:1996;20.
6. (a) Monia B.P., Lesnik E.A., Gonzalez C., Lima W.F., McGee D., Guinosso C.J., Kawasaki A.M., Cook P.D., Freier S.M. J. Biol. Chem. 268:1993;14514.
7. (b) Crooke S.T., Lemonidis K.M., Neilson L., Griffey R., Lesnik E.A., Monia B.P. Biochem. J. 312:1995;599.
8. (c) Lima W.F., Crooke S.T. Biochemistry. 36:1997;390.
9. (d) Zhou W., Agrawal S. Bioorg. Med. Chem. Lett. 8:1998;3269.
10. (e) McKay R.A., Cummins L.L., Graham M.J., Lesnik E.A., Owens S.R., Winniman M., Dean N.M. Nucleic Acids Res. 24:1996;411.
11. (a) Damha M.J., Wilds C.J., Noronha A., Bruckner I., Borkow G., Parniak M.A. J. Am. Chem. Soc. 120:1998;12976.
12. (b) Wilds C.J., Damha M.J. Nucleic Acids Res. 28:2000;3625.
13. (c) Noronha A.M., Wilds C.J., Lok C.N., Viazovkina K., Arion D., Parniak M.A., Damha M.J. Biochemistry. 39:2000;7050.
14. (d) Lok C.N., Viazovkina E., Min K.L., Nagy E., Wilds C.J., Damha M.J., Parniak M.A. Biochemistry. 41:2002;3457.
15. Yang W., Hendrickson W.A., Kalman E.T., Crouch R.J. J. Biol. Chem. 265:1990;13553.
16. Wu H., Lima W.F., Crooke S.T. J. Biol. Chem. 274:1999;28270.
17. Wilds C.J., Damha M.J. Bioconjugate Chem. 10:1999;299.
18. Inoue H., Hayase Y., Iwai S., Ohtsuka E. FEBS Lett. 215:1987;327.
19. Ikeda H., Fernandez R., Wilk A., Barchi J.J., Huang X., Marquez V.E. Nucleic Acids Res. 26:1998;2237.
20. Trempe J.-F., Wilds C.J., Denisov A.Y., Pon R.T., Damha M.J., Gehring K. J. Am. Chem. Soc. 123:2001;4896.
21. Gutierrez A.J., Matteucci M.D., Grant D., Matsumura S., Wagner R.W., Froehler B.C. Biochemistry. 36:1997;743.