Lactate accumulation rather than ATP depletion predicts ischemic myocardial necrosis: Implications for the development of lethal myocardial injury

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1586, Issue 2, 2002, Pages 219-226

  Vogt, Achim M ^a   Ackermann, Cordula ^a   Yildiz, Murat ^a   Schoels, Wolfgang ^a   Kübler, Wolfgang ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

ATP; Energy metabolism; Infarct size; Lactate; Myocardial infarction; Myocardial ischemia

Indexed keywords

ADENOSINE TRIPHOSPHATE; LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; HEART ARREST; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; METABOLISM; MORTALITY; NONHUMAN; PRIORITY JOURNAL; REGRESSION ANALYSIS; SWINE;

ADENOSINE TRIPHOSPHATE; ANIMALS; DISEASE MODELS, ANIMAL; LACTIC ACID; MYOCARDIAL ISCHEMIA; MYOCARDIUM; NECROSIS; REGRESSION ANALYSIS; SWINE;

SUIDAE;

EID: 0037117312     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4439(01)00100-4     Document Type: Article

References (18)

1. Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog
2. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode
3. Dissociation between anti-infarct effect and anti-edema effect of ischemic preconditioning
4. Contractile dysfunction caused by normothermic ischaemia and KCl arrest in the isolated pig heart: A 31-P NMR study
5. Lacking adenosine causes myocardial refractoriness
6. The mechanism of the tetrazolium reaction in identifying experimental myocardial infarction
7. Experimental infarcts and the microcirculation
8. High performance liquid chromatography: A rapid isocratic method for determination of creatine compounds and adenine nucleotides in myocardial tissue
9. Simultaneous detection of high energy phosphates and metabolites of glycolysis and the Krebs cycle by HPLC
10. LOWESS: A program for smoothing scatterplots by robust locally weighted regression
11. The cell biology of acute myocardial ischemia
12. Regulation of glycolysis in the ischemic and anoxic myocardium
13. Ischemic preconditioning slows ischemic metabolism and limits myocardial infarct size
14. Regional hypothermia reduces myocardial necrosis even when instituted after the onset of ischemia
15. Ultrastructural, functional, and biochemical criteria for estimation of reversibility of ischemic injury: A study of the effects of global ischemia in the isolated dog heart
16. Sustained function of normoxic hearts depleted in ATP and phosphocreatine: A 31P-NMR study
17. Role of glycolytic products in damage to ischemic myocardium
18. Total ischemia III: Effect of inhibition of anaerobic glycolysis