Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIβ: Mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability

Nucleic Acids Research

Volumn 30, Issue 24, 2002, Pages 5416-5424

  West, Katherine L ^a,b   Turnbull, Rosalind M ^a   Willmore, Elaine ^a   Lakey, Jeremy H ^a   Austin, Caroline A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); MUTANT PROTEIN; NUCLEOTIDE; PROTEIN DERIVATIVE; SERINE;

BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; DISSOCIATION; DNA BINDING; DNA DEGRADATION; DNA STRAND; ENZYMATIC DEGRADATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE MUTATION; GENETIC COMPLEMENTATION; HUMAN; HYDROLYSIS KINETICS; IN VIVO STUDY; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL; PROTEIN INTERACTION; REDUCTION KINETICS; REVIEW; YEAST;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; DNA; DNA HELICASES; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENETIC COMPLEMENTATION TEST; HUMANS; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SERINE;

EID: 0037115869     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkf677     Document Type: Review

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