Heme inhibits the mitochondrial import of coproporphyrinogen oxidase [2]

Blood

Volumn 100, Issue 13, 2002, Pages 4678-4679

  Susa, Shinji ^b   Daimon, Makoto ^a   Ono, Hideyu ^b   Li, Song ^b   Yoshida, Tadashi ^b   Kato, Takeo ^b  

^a YAMAGATA UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; COMPLEMENTARY DNA; COPROPORPHYRINOGEN OXIDASE; DIHYDROFOLATE REDUCTASE; HEME; PROTEIN PRECURSOR;

CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; DNA LIBRARY; DRUG EFFECT; ENZYME ASSAY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SUBUNIT; ENZYME SYNTHESIS; ERYTHROID CELL; ERYTHROPOIESIS; FEEDBACK SYSTEM; HEMOGLOBIN SYNTHESIS; HUMAN; LETTER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN TRANSPORT;

EID: 0037114691     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-08-2621     Document Type: Letter

References (6)

1. Kramer MF, Gunaratne P, Ferreira GC. Transcriptional regulation of the murine erythroid-specific 5-aminolevulinate synthase gene. Gene. 2000;247:153-166.
2. Lathrop JT, Timko MP. Regulation by heme of mithochondrial protein transport through a conserved amino acid motif. Science. 1993;259:522-525.
3. Woodard SI, Dailey HA. Multiple regulatory steps in erythroid heme biosynthesis. Arch Biochem Biophys. 2000;384:375-378.
4. Taketani S, Furukawa T, Furuyama K. Expression of coproporphyrinogen oxidase and synthesis of hemoglobin in human erythroleukemia K562 cells. Eur J Biochem. 2001;268:1705-1711.
5. Takahashi S, Taketani S, Akasaka J-E, et al. Differential regulation of coproporphyrinogen oxidase gene between erythroid and nonerythroid cells. Blood. 1998;92:3436-3444.
6. Ono H, Yoshimura N, Sato M, Tuboi S. Translocation of proteins into rat liver mitochondria: Existence of two different precurasor polypeptides of liver fumarase and import of the precursor into mitochondria. J Biol Chem. 1985;260:3402-3407.