Alternatives to the hazard ratio in summarizing efficacy in time-to-event studies: An example from influenza trials

Statistics in Medicine

Volumn 21, Issue 23, 2002, Pages 3687-3700

  Keene, Oliver N ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Bootstrap; Hazard; Influenza; Median; Meta analysis; Time to event

Indexed keywords

NEW DRUG; PLACEBO;

ARTICLE; CALCULATION; CLINICAL TRIAL; CONFIDENCE INTERVAL; DATA ANALYSIS; DRUG EFFICACY; ERROR; FOLLOW UP; HEALTH HAZARD; HUMAN; INFLUENZA; META ANALYSIS; NONBIOLOGICAL MODEL; STATISTICAL ANALYSIS; STATISTICS; TIME;

ANTIVIRAL AGENTS; CONFIDENCE INTERVALS; DRUG THERAPY; HUMANS; INFLUENZA, HUMAN; MODELS, STATISTICAL; RANDOMIZED CONTROLLED TRIALS;

EID: 0037114433     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.1312     Document Type: Article

References (18)

1. Parmar MKB, Torri V, Stewart L. Extracting summary statistics to perform meta-analysis of the published literature for survival endpoints. Statistics in Medicine 1998; 17:2815-2834.
2. Sutton AJ, Abrams KR, Jones DR, Sheldon TA, Song F. Methods for Meta-analysis in Medical Research. Wiley: Chichester, 2000; 278.
3. Collett D. Modelling Survival Data in Medical Research. Chapman & Hall: London, 1994; 33-35, 44-45, 192-195, 204-211.
4. Koch GG, Sollecito WA. Statistical considerations in the design, analysis, and interpretation of comparative clinical trials. Drug Information Journal 1984; 18:131-151.
5. International Conference on Harmonisation. Statistical principles for clinical trials. Statistics in Medicine 1999; 18:1905-1942.
6. Yusuf S, Wittes J, Probstfield J, Tyroler HA. Analysis and interpretation of subgroups of patients in randomized clinical trials. Journal of the American Medical Association 1991; 266:93-98.
7. Keene ON. Discussion on 'Consensus and controversy in pharmaceutical statistics' (by Senn S). Journal of the Royal Statistical Society, Series D 2000; 49:160.
8. Senn S. Statistical Issues in Drug Development. Wiley: Chichester, 1997; 39.
9. France LA, Lewis JA, Kay R. The analysis of failure time data in crossover studies. Statistics in Medicine 1991; 10:1099-1113.
10. Parmar MKB, Machin D. Survival Analysis: a Practical Approach. Wiley: Chichester, 1995; 7.
11. Barber JA, Thompson SG. Analysis and interpretation of cost data in randomised controlled trials: review of published studies. British Medical Journal 1998; 317:1995-1200.
12. Keene ON. The log transformation is special. Statistics in Medicine 1995; 14:811-819.
13. Brookmeyer R, Crowley J. A confidence interval for the median survival time. Biometrics 1982; 38:29-41.
14. Lehmann EL. Nonparametrics: Statistical Methods Based on Ranks. Holden-Day Inc: San Francisco, 1975.
15. Efron B, Tibshirani RJ. An Introduction to the Bootstrap. Chapman & Hall: New York, 1993.
16. Carpenter J, Bithell J. Bootstrap confidence intervals: when, which, what? A practical guide for medical statisticians. Statistics in Medicine 2000; 10:1141-1164.
17. Young GA. Bootstrap - more than a stab in the dark? Statistical Science 1994; 9:382-415.
18. DerSimonian R, Laird N. Meta-analysis in clinical trials. Controlled Clinical Trials 1986; 7:177-188.