High-throughput multilevel performance screening of advanced materials

Angewandte Chemie - International Edition

Volumn 41, Issue 22, 2002, Pages 4230-4233

  Potyrailo, Radislav A ^a   Pickett, James E ^a  

^a GENERAL ELECTRIC COMPANY   (United States)

Author keywords

Analytical methods; Combinatorial chemistry; High troughput screening; Materials science

Indexed keywords

FLUORESCENCE; SCREENING; WEATHERING;

MATERIALS RANKING;

POLYMERS;

COPOLYMER; POLY(BUTYLENE TEREPHTHALATE); POLYCARBONATE; POLYMER; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHEMICAL COMPOSITION; COMBINATORIAL CHEMISTRY; FLUORESCENCE; HIGH THROUGHPUT SCREENING; MATERIALS TESTING; POLYMERIZATION; SCREENING; TASK PERFORMANCE; ULTRAVIOLET RADIATION;

EID: 0037112585     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20021115)41:22<4230::AID-ANIE4230>3.0.CO;2-V     Document Type: Article

References (32)

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6. Examples of measured properties of reaction components and final products in combinatorial libraries: a) catalytic properties, A. Holzwarth, H.-W. Schmidt, W. Maier, Angew. Chem. 1998, 110, 2788; Angew. Chem. Int. Ed. 1998, 37, 2644; H. Su, E. S. Yeung, J. Am. Chem. Soc. 2000, 122, 7422; b) polymer molecular weight, S. Brocchini, K. James, V. Tangpasuthadol, J. Kohn, J. Am. Chem. Soc. 1997, 119, 4553; c) thin-film dewetting, J. C. Meredith, A. P. Smith, A. Karim, E. J. Amis, Macromolecules 2000, 33, 9747; d) materials resistivity, X.-D. Xiang, X. Sun, G. Bricefio, Y. Lou, K.-A. Wang, H. Chang, W. G. Wallace-Freedman, S.-W. Chen, P. G. Schultz, Science 1995, 268, 1738; e) mechanical properties, J.-C. Zhao, Adv. Eng. Mater. 2001, 3, 143.
7. Examples of measured properties of reaction components and final products in combinatorial libraries: a) catalytic properties, A. Holzwarth, H.-W. Schmidt, W. Maier, Angew. Chem. 1998, 110, 2788; Angew. Chem. Int. Ed. 1998, 37, 2644; H. Su, E. S. Yeung, J. Am. Chem. Soc. 2000, 122, 7422; b) polymer molecular weight, S. Brocchini, K. James, V. Tangpasuthadol, J. Kohn, J. Am. Chem. Soc. 1997, 119, 4553; c) thin-film dewetting, J. C. Meredith, A. P. Smith, A. Karim, E. J. Amis, Macromolecules 2000, 33, 9747; d) materials resistivity, X.-D. Xiang, X. Sun, G. Bricefio, Y. Lou, K.-A. Wang, H. Chang, W. G. Wallace-Freedman, S.-W. Chen, P. G. Schultz, Science 1995, 268, 1738; e) mechanical properties, J.-C. Zhao, Adv. Eng. Mater. 2001, 3, 143.
8. Examples of measured properties of reaction components and final products in combinatorial libraries: a) catalytic properties, A. Holzwarth, H.-W. Schmidt, W. Maier, Angew. Chem. 1998, 110, 2788; Angew. Chem. Int. Ed. 1998, 37, 2644; H. Su, E. S. Yeung, J. Am. Chem. Soc. 2000, 122, 7422; b) polymer molecular weight, S. Brocchini, K. James, V. Tangpasuthadol, J. Kohn, J. Am. Chem. Soc. 1997, 119, 4553; c) thin-film dewetting, J. C. Meredith, A. P. Smith, A. Karim, E. J. Amis, Macromolecules 2000, 33, 9747; d) materials resistivity, X.-D. Xiang, X. Sun, G. Bricefio, Y. Lou, K.-A. Wang, H. Chang, W. G. Wallace-Freedman, S.-W. Chen, P. G. Schultz, Science 1995, 268, 1738; e) mechanical properties, J.-C. Zhao, Adv. Eng. Mater. 2001, 3, 143.
9. Examples of measured properties of reaction components and final products in combinatorial libraries: a) catalytic properties, A. Holzwarth, H.-W. Schmidt, W. Maier, Angew. Chem. 1998, 110, 2788; Angew. Chem. Int. Ed. 1998, 37, 2644; H. Su, E. S. Yeung, J. Am. Chem. Soc. 2000, 122, 7422; b) polymer molecular weight, S. Brocchini, K. James, V. Tangpasuthadol, J. Kohn, J. Am. Chem. Soc. 1997, 119, 4553; c) thin-film dewetting, J. C. Meredith, A. P. Smith, A. Karim, E. J. Amis, Macromolecules 2000, 33, 9747; d) materials resistivity, X.-D. Xiang, X. Sun, G. Bricefio, Y. Lou, K.-A. Wang, H. Chang, W. G. Wallace-Freedman, S.-W. Chen, P. G. Schultz, Science 1995, 268, 1738; e) mechanical properties, J.-C. Zhao, Adv. Eng. Mater. 2001, 3, 143.
10. Examples of measured properties of reaction components and final products in combinatorial libraries: a) catalytic properties, A. Holzwarth, H.-W. Schmidt, W. Maier, Angew. Chem. 1998, 110, 2788; Angew. Chem. Int. Ed. 1998, 37, 2644; H. Su, E. S. Yeung, J. Am. Chem. Soc. 2000, 122, 7422; b) polymer molecular weight, S. Brocchini, K. James, V. Tangpasuthadol, J. Kohn, J. Am. Chem. Soc. 1997, 119, 4553; c) thin-film dewetting, J. C. Meredith, A. P. Smith, A. Karim, E. J. Amis, Macromolecules 2000, 33, 9747; d) materials resistivity, X.-D. Xiang, X. Sun, G. Bricefio, Y. Lou, K.-A. Wang, H. Chang, W. G. Wallace-Freedman, S.-W. Chen, P. G. Schultz, Science 1995, 268, 1738; e) mechanical properties, J.-C. Zhao, Adv. Eng. Mater. 2001, 3, 143.
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12. Examples of high-throughput performance testing: a) R. A. Potyrailo, D. R. Olson, B. J. Chisholm, M. J. Brennan, J. P. Lemmon, J. N. Cawse, W. P. Flanagan, R. E. Shaffer, T. K. Leib, Pittcon 2001 (New Orleans, LA), 2001, paper 992;
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25. For exposure time and dose, see the Supporting Information.
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28. 2- and CB-PC and PC-PBT showed also distortions and shifts of excitation and emission spectral bands. This suggested that upon weathering the number of different types of generated fluorescent chromophores was roughly constant in PBT and was increasing in PC. For fluorescence spectra, see the Supporting Information.
29. Calculated for the signal-to-noise ratio of three, see: J. D. Ingle, Jr., S. R. Crouch, Spectrochemical Analysis, Prentice Hall, Englewood Cliffs, NJ, 1988.
30. For additional experiments exploring further improvement of the screening throughput, see the Supporting Information.
31. Measurements of polymer fluorescence can be applicable for a variety of aromatic and other types of polymers during weathering testing. If fluorescent additives or initial impurities in polymers present a problem, molecular probes for analysis of surface oxidation products may be more applicable. See: S. R. Holmes-Farley, G. M. Whitesides, Langmuir 1986, 2. 266; V. B. Ivanov, J. Behnisch. A. Hollaender, F. Mehdorn. H. Zimmermann, Surf. Interface Anal. 1996, 24, 257.
32. Measurements of polymer fluorescence can be applicable for a variety of aromatic and other types of polymers during weathering testing. If fluorescent additives or initial impurities in polymers present a problem, molecular probes for analysis of surface oxidation products may be more applicable. See: S. R. Holmes-Farley, G. M. Whitesides, Langmuir 1986, 2. 266; V. B. Ivanov, J. Behnisch. A. Hollaender, F. Mehdorn. H. Zimmermann, Surf. Interface Anal. 1996, 24, 257.