메뉴 건너뛰기




Volumn 64, Issue 10, 2002, Pages 1493-1502

Analytical and pharmacokinetic studies with 5-chloro-2′-deoxycytidine

Author keywords

5 Chloro 2 deoxycytidine; Cytidine deaminase; Pharmacokinetics; Pyrimidine nucleoside metabolism; Radiation sensitization; Tetrahydrouridine

Indexed keywords

5 CHLORODEOXYCYTIDINE; ACETONITRILE; AMMONIUM SULFATE; CLOXURIDINE; CYTIDINE DEAMINASE; CYTIDINE DEAMINASE INHIBITOR; ENZYME INHIBITOR; NSC 371331; PLASMA PROTEIN; SOLVENT; TETRAHYDROURIDINE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

EID: 0037112279     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01413-2     Document Type: Article
Times cited : (23)

References (25)
  • 3
    • 0024327645 scopus 로고
    • Selective radiosensitization and cytotoxicity of human melanoma cells using halogenated deoxycytidines and tetrahydrouridine
    • Lawrence T.S., Davis M.A. Selective radiosensitization and cytotoxicity of human melanoma cells using halogenated deoxycytidines and tetrahydrouridine. Int. J. Radiat. Oncol. Biol. Phys. 16:1989;1243-1246.
    • (1989) Int. J. Radiat. Oncol. Biol. Phys. , vol.16 , pp. 1243-1246
    • Lawrence, T.S.1    Davis, M.A.2
  • 4
    • 0022537065 scopus 로고
    • Sensitization to X-ray by 5-chloro-2′-deoxycytidine co-administered with tetrahydrouridine in several mammalian cell lines and studies of 2′-chloro derivatives
    • Perez L.M., Greer S. Sensitization to X-ray by 5-chloro-2′-deoxycytidine co-administered with tetrahydrouridine in several mammalian cell lines and studies of 2′-chloro derivatives. Int. J. Radiat. Oncol. Biol. Phys. 12:1986;1523-1527.
    • (1986) Int. J. Radiat. Oncol. Biol. Phys. , vol.12 , pp. 1523-1527
    • Perez, L.M.1    Greer, S.2
  • 5
    • 0022447896 scopus 로고
    • In vitro and in vivo radiation sensitization by the halogenated pyrimidine 5-chloro-2′-deoxycytidine
    • Russell K.J., Rice G.C., Brown J.M. In vitro and in vivo radiation sensitization by the halogenated pyrimidine 5-chloro-2′-deoxycytidine. Cancer Res. 46:1986;2883-2887.
    • (1986) Cancer Res. , vol.46 , pp. 2883-2887
    • Russell, K.J.1    Rice, G.C.2    Brown, J.M.3
  • 6
    • 0029084560 scopus 로고
    • Five-chlorodeoxycytidine and biomodulators of its metabolism result in fifty to eighty percent cures of advanced EMT-6 tumors when used with fractionated radiation
    • Greer S., Schwade J., Marion H.S. Five-chlorodeoxycytidine and biomodulators of its metabolism result in fifty to eighty percent cures of advanced EMT-6 tumors when used with fractionated radiation. Int. J. Radiat. Oncol. Biol. Phys. 32:1995;1059-1069.
    • (1995) Int. J. Radiat. Oncol. Biol. Phys. , vol.32 , pp. 1059-1069
    • Greer, S.1    Schwade, J.2    Marion, H.S.3
  • 9
    • 84965817209 scopus 로고
    • Comparative studies of the cytostatic action and metabolism of 5-azacytidine and 5,6-dihydro-5-azacytidine
    • Voytek P., Beisler J.A., Abbasi M.M., Wolpert-DeFillippes M.K. Comparative studies of the cytostatic action and metabolism of 5-azacytidine and 5,6-dihydro-5-azacytidine. Cancer Res. 37:1977;1956-1961.
    • (1977) Cancer Res. , vol.37 , pp. 1956-1961
    • Voytek, P.1    Beisler, J.A.2    Abbasi, M.M.3    Wolpert-DeFillippes, M.K.4
  • 11
    • 0026550123 scopus 로고
    • 5-Chlorodeoxycytidine a radiosensitizer effective against RIF-1 and Lewis lung carcinoma, is also effective against a DMBA-induced mammary adenocarcinoma and the EMT-6 tumor in BALB/c mice
    • Greer S., Santos O., Gottlieb C., Schwade J., Marion H.S. 5-Chlorodeoxycytidine a radiosensitizer effective against RIF-1 and Lewis lung carcinoma, is also effective against a DMBA-induced mammary adenocarcinoma and the EMT-6 tumor in BALB/c mice. Int. J. Radiat. Oncol. Biol. Phys. 22:1992;505-510.
    • (1992) Int. J. Radiat. Oncol. Biol. Phys. , vol.22 , pp. 505-510
    • Greer, S.1    Santos, O.2    Gottlieb, C.3    Schwade, J.4    Marion, H.S.5
  • 12
    • 0022340625 scopus 로고
    • Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies
    • Mekras J.A., Boothman D.A., Greer S.B. Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies. Cancer Res. 45:1985;5270-5280.
    • (1985) Cancer Res. , vol.45 , pp. 5270-5280
    • Mekras, J.A.1    Boothman, D.A.2    Greer, S.B.3
  • 14
    • 0031114142 scopus 로고    scopus 로고
    • Preclinical pharmacologic, and phase I studies of gemcitabine
    • Storniolo A.M., Allerheiligen S.R.V., Pearce H.L. Preclinical pharmacologic, and phase I studies of gemcitabine. Semin. Oncol. 24:1997;S72-S77.
    • (1997) Semin. Oncol. , vol.24 , pp. S72-S77
    • Storniolo, A.M.1    Allerheiligen, S.R.V.2    Pearce, H.L.3
  • 16
    • 0017729835 scopus 로고
    • Tetrahydrouridine: Physiologic disposition and effect upon deamination of cytosine arabinoside in man
    • Kreis W., Woodcock T.M., Gordon C.S., Krakoff I.H. Tetrahydrouridine: physiologic disposition and effect upon deamination of cytosine arabinoside in man. Cancer Treat. Rep. 61:1977;1347-1353.
    • (1977) Cancer Treat. Rep. , vol.61 , pp. 1347-1353
    • Kreis, W.1    Woodcock, T.M.2    Gordon, C.S.3    Krakoff, I.H.4
  • 17
    • 0030608798 scopus 로고    scopus 로고
    • 4-octadecyl-1-β-D-arabinofuranosylcytosine in plasma and whole blood after intravenous and oral administration to mice
    • 4-octadecyl-1-β-D-arabinofuranosylcytosine in plasma and whole blood after intravenous and oral administration to mice. J. Pharm. Pharmacol. 49:1997;1076-1081.
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 1076-1081
    • Rentsch, K.M.1    Schwendener, R.A.2    Schott, H.3    Hänseler, E.4
  • 18
    • 0024340761 scopus 로고
    • Modulation of the metabolism and pharmacokinetics of 1-β-D-arabinofuranosylcytosine by 1-β-D-arabinofuranosyluracil in leukemic mice
    • Chandrasekaran B., Capizzi R.L., Kute T., Morgan T., Dimling J. Modulation of the metabolism and pharmacokinetics of 1-β-D-arabinofuranosylcytosine by 1-β-D-arabinofuranosyluracil in leukemic mice. Cancer Res. 49:1989;3259-3266.
    • (1989) Cancer Res. , vol.49 , pp. 3259-3266
    • Chandrasekaran, B.1    Capizzi, R.L.2    Kute, T.3    Morgan, T.4    Dimling, J.5
  • 19
    • 0026323307 scopus 로고
    • Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues
    • Driscoll J.S., Marquez V.E., Plowman J., Liu P.S., Kelley J.A., Barchi J.J. Jr. Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues. J. Med. Chem. 34:1991;3280-3284.
    • (1991) J. Med. Chem. , vol.34 , pp. 3280-3284
    • Driscoll, J.S.1    Marquez, V.E.2    Plowman, J.3    Liu, P.S.4    Kelley, J.A.5    Barchi, J.J.6
  • 22
    • 0025184556 scopus 로고
    • Purification and characterization of uridine and thymidine phosphorylase from Lactobacillus casei
    • Avraham Y., Grossowicz N., Yashphe J. Purification and characterization of uridine and thymidine phosphorylase from Lactobacillus casei. Biochim. Biophys. Acta. 1040:1990;287-293.
    • (1990) Biochim. Biophys. Acta , vol.1040 , pp. 287-293
    • Avraham, Y.1    Grossowicz, N.2    Yashphe, J.3
  • 23
    • 0019390965 scopus 로고
    • Continuous spectrophotometric assay of thymidine phosphorylase using 5-nitro-2′-deoxyuridine as substrate
    • Wataya Y., Santi D.W. Continuous spectrophotometric assay of thymidine phosphorylase using 5-nitro-2′-deoxyuridine as substrate. Anal. Biochem. 112:1981;96-98.
    • (1981) Anal. Biochem. , vol.112 , pp. 96-98
    • Wataya, Y.1    Santi, D.W.2
  • 24
    • 0018869122 scopus 로고
    • Thymidine phosphorylase. Substrate specificity for 5-substituted 2′-deoxyuridines
    • Nakayama C., Wataya Y., Meyer R.B. Jr., Santi D.V., Saneyoshi M., Ueda T. Thymidine phosphorylase. Substrate specificity for 5-substituted 2′-deoxyuridines. J. Med. Chem. 23:1980;962-964.
    • (1980) J. Med. Chem. , vol.23 , pp. 962-964
    • Nakayama, C.1    Wataya, Y.2    Meyer, R.B.3    Santi, D.V.4    Saneyoshi, M.5    Ueda, T.6
  • 25
    • 0017227849 scopus 로고
    • Uridine phosphorylase from Escherichia coli: Kinetic properties and mechanism
    • Krenitsky T.A. Uridine phosphorylase from Escherichia coli: kinetic properties and mechanism. Biochim. Biophys. Acta. 429:1976;352-358.
    • (1976) Biochim. Biophys. Acta , vol.429 , pp. 352-358
    • Krenitsky, T.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.