Experimental colonization of mice by fresh clinical isolates of Helicobacter pylori is not influenced by the cagA status and the vacA genotype

FEMS Immunology and Medical Microbiology

Volumn 34, Issue 3, 2002, Pages 169-172

  Ayraud, Sarah ^a   Janvier, Blandine ^a   Fauchère, Jean Louis ^a  

^a UNIVERSITÉ DE POITIERS   (France)

Author keywords

CagA status; Helicobacter pylori; Mouse colonization; VacA genotype

Indexed keywords

CAGA PROTEIN; PROTEIN; UNCLASSIFIED DRUG; VACUOLATING TOXIN; VIRULENCE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CONTROLLED STUDY; FEMALE; GENOTYPE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; INOCULATION; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; MUTATION; VIRULENCE FACTORS;

EID: 0037112087     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(02)00350-4     Document Type: Article

References (21)

1. Marshall B.J., Warren J.R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1:1984;1311-1315.
2. Rautelin H., Kosunen T.U. Helicobacter pylori and associated gastroduodenal diseases. APMIS. 99:1991;677-695.
3. The Eurogast Study Group (1993) An international association between Helicobacter pylori infection and gastric cancer. Lancet 341, 1359-1362.
4. Janvier B., Grignon B., Audibert C., Pezennec L., Fauchere J.L. Phenotypic changes of Helicobacter pylori components during an experimental infection in mice. FEMS Immunol. Med. Microbiol. 24:1999;27-33.
5. Marchetti M., Arico B., Burroni D., Figura N., Rappuoli R., Ghiara P. Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science. 267:1995;1655-1658.
6. Björkholm, B., Engstrand, L. and Falk, P. (1998) Infections with cagA positive/negative Helicobacter pylori isolates in a transgenic mouse model. In: Proceedings of the 3rd International Workshop on Pathogenesis and Host Response in Helicobacter Infections, Helsingor, Denmark.
7. Philpott O.J., Belaid D., Troubadour P., Tankovic J., Sansonetti P.J., Labigne A., Ferrero R.L. Reduced inflammatory responses induced by Helicobacter pylori isolates: a selective advantage in adaptation to the murine host. Int. J. Med. Microbiol. 29:(Abstract O.20):2001;135.
8. Salama N.R., Otto G., Tompkins L., Falkow S. Vacuolating cytotoxin of Helicobacter pylori plays a role during colonisation in a mouse model of infection. Infect. Immun. 69:2001;730-736.
9. Harris P.R., Cover T.L., Crowe D.R., Orenstein J.M., Graham M.F., Blaser M.J., Smith P.D. Helicobacter pylori cytotoxin induces vacuolation of primary human mucosal epthelial cells. Infect. Immun. 64:1996;4867-4871.
10. Tomb J.F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleishmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A., Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B., Richardson D., Dodson R., Khalak H.G., Glodeck A., Mc Kenney K., Fitzerald L.M., Lee N., Adams M.D., Berg D.E., Venter J.C., et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 388:1997;539-547.
11. Alm R.A., Ling L.S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., Dejonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nackelsen M., Mills D.M., Ives C., Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trsust T.J. Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 397:1999;176-180.
12. Lee A., O'Rourke J., Corazon de Ungria M., Robertson B., Daskalopoulos G., Dixon M.F. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology. 112:1997;1386-1397.
13. Tummuru M.K.R., Cover T.L., Blaser M.J. Cloning and expression of a high molecular mass major antigen of Helicobacter pylori: evidence of a linkage to cytotoxin production. Infect. Immun. 61:1993;1799-1809.
14. Atherton J.C., Cao P., Peek R.M., Tummuru M.K. Jr., Blaser M.J., Cover T.L. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 270:1995;17771-17777.
15. Ghiara P., Marchetti M., Blaser M.J., Tummuru M.K., Cover T.L., Segal E.D., Tompkins L.S., Rappuoli R. Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease. Infect. Immun. 63:1995;4154-4160.
16. Sheu B.S., Yang H.B., Wu J.J., Huang A.H., Lin X.Z., Su I.J. Development of Helicobacter pylori infection model in BALB/c mice with domestic cagA-positive and -negative strains in Taiwan. Dig. Dis. Sci. 44:1999;868-875.
17. Thompson L.J., Danon S., Wilson J., O'Rourke J., Salama N., Falkow S., Mitchell H., Lee A. Presence of the cag pathogenicity island does not affect the level of colonization or inflammation in mice infected with Helicobacter pylori. Int. J. Med. Microbiol. 291:(Abstract O.25):2001;137.
18. Audibert C., Janvier B., Grignon B., Salaun L., Burucoa C., Lecron J.C., Fauchère J.L. Prevalence of 3 virulence markers of Helicobacter pylori in 150 french isolates: vacA genotypes, cagA status and IL-8 induction. Res. Microbiol. 151:2000;1-10.
19. Van Doorn L.J., Figueiredo C., Megraud F., Pena S., Midolo P., Queiroz D.M., Carneiro F., Vanderborght B., Pegado M.D., Sanna R., DeBoer W., Schneeberger P.M., Correa P., Ng E.K., Atherton J., Blaser M.J., Quint W.G. Geographic distribution of vacA allelic types of Helicobacter pylori. Gastroenterology. 116:1999;823-830.
20. Josenhans C., Eaton K.A., Thevenot T., Suerbaum S. Switching of flagellar motility in Helicobacter pylori by reversible length variation of a short homopolymeric sequence repeat in fliP, a gene encoding a basal body protein. Infect. Immun. 68:2000;4598-4603.
21. Konturek P.C., Brzozowski T., Konturek S.J., Stachura J., Karczewska E., Pajdo R., Ghiara P., Hahn E.G. Mouse model of Helicobacter pylori infection: studies of gastric function and ulcer healing. Aliment. Pharmacol. Ther. 13:1999;333-346.