Furin gene (fur) regulation in differentiating human megakaryoblastic Dami cells: Involvement of the proximal GATA recognition motif in the P1 promoter and impact on the maturation of furin substrates

Blood

Volumn 100, Issue 10, 2002, Pages 3578-3587

  Laprise, Marie Hélène ^a   Grondin, Francine ^a   Cayer, Pauline ^a   McDonald, Patrick P ^a   Dubois, Claire M ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FURIN; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PLATELET DERIVED GROWTH FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MEGAKARYOBLAST; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; THROMBOCYTE FUNCTION;

EID: 0037111737     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V100.10.3578     Document Type: Article

References (72)

1. Dubois CM, Laprise MH, Blanchette F, Gentry LE, Leduc R. Processing of transforming growth factor β1 precursor by human furin convertase. J Biol Chem. 1995;270:10618-10624.
2. Dubois CM, Blanchette F, Laprise MH, Leduc R, Grondin F, Seidah NG, Evidence that furin is an authentic transforming growth factor beta 1 converting enzyme. Am J Pathol. 2001;158:305-316.
3. Cochran BH, Reffel AC, Stiles CD. Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell. 1983;33:939-947.
4. Poncz M, Eisman R, Heidenreich R, Silver SM, Vilaire G, Surrey S, Schwartz E, Bennett JS. Structure of the platelet membrane glycoprotein IIb: Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors. J Biol Chem. 1987;262:8476-8482.
5. Rehemtulla A, Kaufman RJ. Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes. Blood. 1992;79:2349-2355.
6. Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ, Kaufman RJ. Expression of a human proprotein processing enzyme: Correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. Proc Natl Acad Sci U S A. 1990;87:9378-9382.
7. Logeat F, Bessia C, Brou C, et al. The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci U S A. 1998;95:8108-8112.
8. Zhou A, Webb G, Zhu X, Steiner DF. Proteolytic processing in the secretory pathway. J Biol Chem. 1999;274:20745-20748.
9. Seidah NG, Day R, Benjannet S, et al. The prohormone and proprotein processing enzymes PC1 and PC2: Structure, selective cleavage of mouse POMC and human renin at pairs of basic residues, cellular expression, tissue distribution, and mRNA regulation. NIDA Res Monogr Rev. 1992;126:132-150.
10. Seidah NG, Marcinkiewicz M, Benjannet S, et al. Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: Distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol Endocrinol. 1991;5:111-122.
11. Nakayama K, Kim WS, Torii S, et al. Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease: Its testis-specific expression. J Biol Chem. 1992;267:5897-5900.
12. Schalken JA, Roebroek AJM, Oomen PPCA, et al. FUR gene expression as a discriminating marker in human lung cancer. J Clin Invest. 1987;80:1545-1549.
13. Seidah NG, Chrétien M, Day R. The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions. Biochimie (Paris). 1994;76:197-209.
14. Zheng M, Streck RD, Scott RE, Seidah NG, Pintar JE. The developmental expression in rat of proteases furin, PC1, PC2 and carboxypeptidase E: Implications for early maturation of proteolytic processing capacity. J Neurosci. 1994;14:4656-4673.
15. Dickson MC, Slager HG, Duffie E, Mummery CL, Akhurst RJ. RNA and protein localisations of TGF beta 2 in the early mouse embryo suggest an involvement in cardiac development. Development. 1993;117:625-639.
16. Jones CM, Lyons KM, Hogan BLM. Involvement of bone morphogenesis and neurogenesis in the mouse. Development. 1991;111:531-542.
17. Lyons KM, Hogan BL, Robertson EJ. Colocalization of BMP7 and BMP2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development. Mech Dev. 1995;50:71-83.
18. Lee JE, Pintar JE, Efstratiadis A. Pattern of insulin-like growth factor II gene expression during early mouse embryogenesis. Development. 1990;110:151-159.
19. Hoshino H, Konda Y, Takeuchi T. Co-expression of the proprotein-processing endoprotease furin and its substrate transforming growth factor beta1 and the differentiation of rat hepatocytes. FEBS Lett. 1997;419:9-12.
20. Jones RO. Ultrastructural analysis of hepatic haematopoiesis in the foetal mouse. J Anat. 1970;107:301-314.
21. Fava RA, Casey TT, Wilcox J, Pelton RW, Moses HL, Nanney LB. Synthesis of transforming growth factor-beta 1 by megakaryocytes and its localization to megakaryocyte and platelet alpha-granules. Blood. 1990;76:1946-1955.
22. Ayoubi TA, Creemers JW, Roebroek AJ, Van de Ven WJ. Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters. J Biol Chem. 1994;269:9298-9303.
23. Blanchette F, Rudd P, Grondin F, Attisano L, Dubois CM. Involvement of Smads in TGFβ1-induced furin (fur) transcription. J Cell Physiol. 2001;188:264-273.
24. George JN. Platelets. Lancet. 2000;355:1531-1539.
25. Jahroudi N, Lynch DC. Endothelial cell-specific regulation of von Willebrand factor gene expression. Mol Cell Biol. 1994;14:999-1008.
26. Martin F, Prandini MH, Thevenon D, Marguerie G, Uzan G. The transcription factor GATA-1 regulates the promoter activity of the platelet glycoprotein IIb gene. J Biol Chem. 1993;268:21606-21612.
27. Minami T, Tachibana K, Imanishi T, Doi T. Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression. Eur J Biochem. 1998;258:879-889.
28. Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997;16:3965-3973.
29. Orkin SH, Shivdasani RA, Fujiwara Y, McDevitt MA. Transcription factor GATA-1 in megakaryocyte development. Stem Cells. 1998;16:79-83.
30. Charron F, Nemer M. GATA transcription factors and cardiac development. Semin Cell Dev Biol. 1999;10:85-91.
31. Tsai SF, Martin DI, Zon LI, Dandrea AD, Wong GG, Orkin SH. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 1989;339:446-451.
32. Martin DI, Zon LI, Mutter G, Orkin SH. Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature. 1990;344:444-447.
33. Zon LI, Yamaguchi Y, Yee K, et al. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: Potential role in gene transcription. Blood. 1993;81:3234-3241.
34. Weiss MJ, Orkin SH. GATA transcription factors: Key regulators of hematopoiesis. Exp Hematol. 1995;23:99-107.
35. Trainor CD, Omichinski JG, Vandergon TL, Gronenborn AM, Clore GM, Felsenfeld G. A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction. Mol Cell Biol. 1996;16:2238-2247.
36. Tsang AP, Visvader JE, Turner CA, et al. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell. 1997;90:109-119.
37. Fox AH, Liew C, Holmes M, Kowalski K, Mackay J, Crossley M. Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers. EMBO J. 1999;18:2812-2822.
38. Gaines P, Geiger JN, Knudsen G, Seshasayee D, Wojchowski DM. GATA-1 and FOG-dependent activation of megakaryocytic αIIB gene expression. J Biol Chem. 2000;275:34114-34121.
39. Tsang AP, Fujiwara Y, Hom DB, Orkin SH. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 1998;12:1176-1188.
40. Greenberg SM, Rosenthal DS, Greeley TA, Tantravahi R, Handin RI. Characterization of a new megakaryocytic cell line: The Dami cell. Blood. 1988;72:1968-1977.
41. Yamaguchi Y, Zon LI, Ackerman SJ, Yamamoto M, Suda T. Forced GATA-1 expression in the murine myeloid cell line M1: Induction of c-Mpl expression and megakaryocytic/erythroid differentiation. Blood. 1998;91:450-457.
42. Chomzcynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques. 1993;15:532-534.
43. Langlois MF, Zanger K, Monden T, Safer JD, Hollenberg AN, Wondisford FE. A unique role of the beta-2 thyroid hormone receptor isoform in negative regulation by thyroid hormone: Mapping of a novel amino-terminal domain important for ligand-independent activation. J Biol Chem. 1997;272:24927-24933.
44. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl Acids Res. 1983;11:1475-89.
45. McDonald PP, Fadok VA, Bratton D, Henson PM. Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells. J Immunol. 1999;163:6164-6172.
46. Mosser DD, Caron AW, Bourget L, Jolicoeur P, Massie B. Use of a dicistronic expression cassette encoding the green fluorescent protein for the screening and selection of cells expressing inducible gene products. Biotechniques. 1997;22:150-154, 156, 158-161.
47. Petrof BJ, Acsadi G, Jani A, et al. Efficiency and functional consequences of adenovirus-mediated in vivo gene transfer to normal and dystrophic (mdx) mouse diaphragm. Am J Respir Cell Mol Biol. 1995;13:508-517.
48. Okabe M, Kunieda Y, Shoji M, et al. Megakaryocytic differentiation of a leukemic cell line, MC3, by phorbol ester: Induction of glycoprotein IIb/IIIa and effects on expression of IL-6, IL-6 receptor, mpl and GATA genes. Leuk Res. 1995;19:933-943.
49. Takeuchi K, Ogura M, Saito H, Satoh M, Takeuchi M. Production of platelet-like particles by a human megakaryoblastic leukemia cell line (MEG01). Exp Cell Res. 1991;193:223-226.
50. Ogura M, Morishima Y, Ohno R, et al. Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome. Blood. 1985;66:1384-1392.
51. Stendahl O, Dahlgren C, Hed J. Physicochemical and functional changes in human leukemic cell line HL-60. J Cell Physiol. 1982;112:217-221.
52. Bloom GS, Brashear TA. A novel 58-kDa protein associates with the Golgi apparatus and microtubules. J Biol Chem. 1989;264:16083-16092.
53. Molloy SS, Thomas L, Van Slyke JK, Stenberg PE, Thomas G. Intracellular trafficking and activation of the furin proprotein convertase: Localization to the TGN and recycling from the cell surface. EMBO J. 1994;13:18-33.
54. Martin DI, Orkin SH. Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1. Genes Dev. 1990;4:1886-1898.
55. Querfurth E, Schuster M, Kulessa H, et al. Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors. Genes Dev. 2000;14:2515-2525.
56. Jean F, Stella K, Thomas L, et al. Alpha1-antitrypsin Portland, a bioengineered serpin highly selective for furin: Application as an antipathogenic agent. Proc Natl Acad Sci U S A. 1998;95:7293-7298.
57. Taxman DJ, Wojchowski DM. Erythropoietin-induced transcription at the murine beta maj-globin promoter: A central role for GATA-1. J Biol Chem. 1995;270:6619-6627.
58. Deveaux S, Filipe A, Lemarchandel V, Ghysdael J, Romeo PH, Mignotte V. Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes. Blood. 1996;87:4678-4685.
59. Gumina RJ, Kirschbaum NE, Piotrowski K, Newman PJ. Characterization of the human platelet/endothelial cell adhesion molecule-1 promoter: Identification of a GATA-2 binding element required for optimal transcriptional activity. Blood. 19997;89:1260-1269.
60. Whyatt DJ, deBoer E, Grosveld FL. The two zinc finger-like domains of GATA-1 have different DNA binding specificities. EMBO J. 1993;12:4993-5005.
61. Prandini MH, Martin F, Thevenon D, Uzan G. The tissue-specific transcriptional regulation of the megakaryocytic glycoprotein IIb gene is controlled by interactions between a repressor and positive cis-acting elements. Blood. 1996;88:2062-2070.
62. Nagata Y, Nagahisa H, Aida Y, Okutomi K, Nagasawa T, Todokoro K. Thrombopoietin induces megakaryocyte differentiation in hematopoietic progenitor FDC-P2 cells. J Biol Chem. 1995;270:19673-19675.
63. Alitalo R, Andersson LC, Betsholtz C, et al. Induction of platelet-derived growth factor gene expression during megakaryoblastic and monocytic differentiation of human leukemia cell lines. EMBO J. 1987;6:1213-1218.
64. Fava RA, Casey TT, Wilcox J, Pelton RW, Moses HL, Nanney LB. Synthesis of transforming growth factor-beta 1 by megakaryocytes and its localization to megakaryocyte and platelet alpha-granules. Blood. 1990;76:1946-1955.
65. Greenberg SM, Chandrasekhar C. Hematopoietic factor-induced synthesis of von Willebrand factor by the Dami human megakaryoblastic cell line and by normal human megakaryocytes. Exp Hematol. 1991;19:53-58.
66. Soligo D, Schiro R, Luksch R, et al. Expression of integrins in human bone marrow. Br J Haematol. 1990;76:323-332.
67. Grainick HR, Williams SB, Coller BS. Asialo von Willebrand factor interactions with platelets: Interdependence of glycoproteins Ib and IIb/IIIa for binding and aggregation. J Clin Invest. 1985;75:19-25.
68. De Marco L, Girolami A, Russell S, Ruggeri ZM. Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation. J Clin Invest. 1985;75:1198-1203.
69. Nabel EG, Shum L, Pompili VJ, et al: Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Proc Natl Acad Sci U S A. 1993;90:10759-10763.
70. Bernstein LR, Antoniades H, Zetter BR. Migration of cultured vascular cells in response to plasma and platelet-derived factors. J Cell Sci. 1982;56:71-82.
71. Hoying JB, Yin M, Diebold R, Ormsby I, Becker A, Doetschman T. Transforming growth factor beta1 enhances platelet aggregation through a nontranscriptional effect on the fibrinogen receptor. J Biol Chem. 1999;274:31008-31013.
72. Lam LT, Ronchini C, Norton J, Capobianco AJ, Bresnick EH. Suppression of erythroid but not megakaryocytic differentiation of human K562 erythroleukemic cells by Notch-1. J Biol Chem. 2000;275:19676-19684.