MRI subcortical hyperintensities in old and very old depressed outpatients: The important role of age in late-life depression

Journal of the Neurological Sciences

Volumn 203-204, Issue , 2002, Pages 227-233

  Salloway, Stephen ^a,f   Correia, Stephen ^a   Boyle, Patricia ^a   Malloy, Paul ^a   Schneider, Lon ^b   Lavretsky, Helen ^c   Sackheim, Harold ^d   Roose, Steven ^d   Krishnan, K Ranga Rama ^e  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e DUKE UNIVERSITY   (United States)

^f BUTLER HOSPITAL   (United States)

Author keywords

Cardiovascular risk factors; Citalopram; Geriatric depression; MRI; Sertraline; Subcortical hyperintensities; Vascular depression

Indexed keywords

CITALOPRAM; SERTRALINE;

ADULT; AGED; BRAIN CORTEX; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; HUMAN; MAJOR CLINICAL STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; OUTPATIENT; PRIORITY JOURNAL;

AGE OF ONSET; AGED; AGING; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BRAIN; CITALOPRAM; DEMENTIA, VASCULAR; DEPRESSIVE DISORDER; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; OUTPATIENTS; PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS; SERTRALINE; TREATMENT OUTCOME;

EID: 0037111498     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(02)00296-4     Document Type: Conference Paper

References (35)

1. Gottfries C.G. Late life depression. Eur. Arch. Psychiatry Clin. Neurosci. 251(Suppl. 2):2001;II57-II61.
2. Krishnan K.R.R., Hays J.C., Blazer D.G. MRI-defined vascular depression. Am. J. Psychiatry. 154(4):1997;497-501.
3. Doraiswamy P.M., Khan Z.M., Donahue R.M., Richard N.E. The spectrum of quality-of-life impairments in recurrent geriatric depression. J. Gerontol., Ser. A, Biol. Sci. Med. Sci. 57(2):2002;M134-M137.
4. Krishnan K.R. Depression as a contributing factor in cerebrovascular disease. Am. Heart J. 140(4 Suppl.):2000;70-76.
5. Reynolds C.F. III Treatment of depression in late life. Am. J. Med. 97(6A):1994;39S-46S.
6. Lynch T.R., Johnson C.S., Mendelson T., Robins C.J., Krishnan K.R., Blazer D.G. Correlates of suicidal ideation among an elderly depressed sample. J. Affect. Disord. 56:1999;9-15.
7. Reynolds C.F. III, Alexopoulos G.S., Katz I.R., Lebowitz B.D. Chronic depression in the elderly: approaches for prevention. Drugs Aging. 18(7):2001;507-514.
8. Alexopoulos G.S., Meyers B.S., Young R.C., Campbell S., Silbersweig D., Charlson M. 'Vascular depression' hypothesis. Arch. Gen. Psychiatry. 54:1997;915-922.
9. Coffey C.E., Figiel G.S., Djang W.T., Saunders W.B., Weiner R.D. White matter hyperintensity on magnetic resonance imaging: clinical and neuroanatomic correlates in the depressed elderly. J. Neuropsychiatry Clin. Neurosci. 1(2):1989;135-144.
10. Krishnan K.R., Goli V., Ellinwood E.H., France R.D., Blazer D.G., Nemeroff C.B. Leukoencephalopathy in patients diagnosed as major depressive. Biol. Psychiatry. 23(5):1988;519-522.
11. de Groot J.C., de Leeuw F.E., Oudkerk M., Hofman A., Jolles J., Breteler M.M. Cerebral white matter lesions and depressive symptoms in elderly adults. Arch. Gen. Psychiatry. 57(11):2000;1071-1076.
12. MacFall J.R., Payne M.E., Provenzale J.E., Krishnan K.R. Medial orbital frontal lesions in late-onset depression. Biol. Psychiatry. 49(9):2001;803-806.
13. Salloway S., Malloy P., Kohn R., Gillard E., Duffy J., Rogg J.et al. MRI and neuropsychological differences in early- and late-life-onset geriatric depression. Neurology. 46(6):1996;1567-1574.
14. Jenkins M., Malloy P., Salloway S., Cohen R., Rogg J., Tung G.et al. Memory processes in depressed geriatric patients with and without subcortical hyperintensities on MRI. J. Neuroimaging. 8(1):1998;20-26.
15. Breteler M.M., van Amerongen N.M., van Swieten J.C., Claus J.J., Grobbee D.E., van Gijn J.et al. Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study. Stroke. 25(6):1994;1109-1115.
16. Liao D., Cooper L., Cai J., Toole J., Bryan N., Burke G.et al. The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study. Neuroepidemiology. 16(3):1997;149-162.
17. Longstreth W.T. Jr., Manolio T.A., Arnold A., Burke G.L., Bryan N., Jungreis C.A.et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke. 27(8):1996;1274-1282.
18. Ylikoski A., Erkinjuntti T., Raininko R., Sarna S., Sulkava R., Tilvis R. White matter hyperintensities on MRI in the neurologically nondiseased elderly. Analysis of cohorts of consecutive subjects aged 55 to 85 years living at home. Stroke. 26(7):1995;1171-1177.
19. Fazekas F., Niederkorn K., Schmidt R., Offenbacher H., Horner S., Bertha G.et al. White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. Stroke. 19(10):1988;1285-1288.
20. Lindgren A., Roijer A., Rudling O., Norrving B., Larsson E.M., Eskilsson J.et al. Cerebral lesions on magnetic resonance imaging, heart disease, and vascular risk factors in subjects without stroke. A population-based study. Stroke. 25(5):1994;929-934.
21. de Leeuw F.E., de Groot J.C., Breteler M.M.B. White matter changes: frequency and risk factors. Pantoni L., Intzitari D., Wallin A. The Matter of White Matter: Clinical and Pathophysiological Aspects of White Matter Disease Related to Cognitive Decline and Vascular Dementia. 2000;19-33 Academic Pharmaceutical Productions, Utrecht, Netherlands.
22. Hickie I., Scott E., Mitchell P., Wilhelm K., Austin M.P., Bennett B. Subcortical hyperintensities on magnetic resonance imaging: clinical correlates and prognostic significance in patients with severe depression. Biol. Psychiatry. 37(3):1995;151-160.
23. Simpson S., Baldwin R.C., Jackson A., Burns A.S. Is subcortical disease associated with a poor response to antidepressants? Neurological, neuropsychological and neuroradiological findings in late-life depression. Psychol. Med. 28(5):1998;1015-1026.
24. Steffens D.C., Conway C.R., Dombeck C.B., Wagner H.R., Tupler L.A., Weiner R.D. Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression. J. ECT. 17(1):2001;45-49.
25. Schneider L., Clary C.M., Finkel S., Krishnan K.R., Doraiswamy M. Sertraline in the Treatment of Elderly Depression: Results of a Large, Multicenter, Placebo-controlled Trail. vol. 290:2000;2000 American Psychiatric Association, Washington, DC.
26. Krishnan K.R., McDonald W.M., Doraiswamy P.M., Tupler L.A., Husain M., Boyko O.B.et al. Neuroanatomical substrates of depression in the elderly. Eur. Arch. Psychiatry Clin. Neurosci. 243(1):1993;41-46.
27. Salloway S., Jenkins M., Intal J., Javorsky D., Malloy P. FLAIR is more sensitive than proton density weighting for visualizing and measuring SH in geriatric depression. J. Neuropsychiatry Clin. Neurosci. 11:1999;155.
28. Kumar A., Bilker W., Jin Z., Udupa J., Gottlieb G. Age of onset of depression and quantitative neuroanatomic measures: absence of specific correlates. Psychiatry Res. 91(2):1999;101-110.
29. Lyness J.M., Caine E.D., Cox C., King D.A., Conwell Y., Olivares T. Cerebrovascular risk factors and later-life major depression. Testing a small-vessel brain disease model. Am. J. Geriatr. Psychiatry. 6(1):1998;5-13.
30. Lyness J., Caine E., King L.D., Conwell Y., Cox C., Duberstein P. Cerebrovascular risk factors and depression in older primary care patients: testing a vascular brain disease model of depression. Am. J. Geriatr. Psychiatry. 7:1999;252-258.
31. Kumar A., Miller D., Ewbank D., Yousem D., Newberg A., Samuels S.et al. Quantitative anatomic measures and comorbid medical illness in late-life major depression. Am. J. Geriatr. Psychiatry. 5(1):1997;15-25.
32. Krishnan K.R., Hays J.C., Tupler L.A., George L.K., Blazer D.G. Clinical and phenomenological comparisons of late-onset and early-onset depression. Am. J. Psychiatry. 152(5):1995;785-788.
33. Alexopoulos G.S., Kiosses D.N., Kimstra S., Kalayam B., Bruce M.L. Clinical presentation of the "Depression - Executive Dysfunction Syndrome" of late life. Am. J. Geriatr. Psychiatry. 10:2002;98-106.
34. Reding M., Haycox J., Blass J. Depression in patients referred to a dementia clinic. A three-year prospective study. Arch. Neurol. 42(9):1985;894-896.
35. Salloway S., Boyle P.A., Correia S., Malloy P.F., Cahn-Weiner D.A., Schneider L.et al. The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients. Am. J. Geriatr. Psychiatry. 10(1):2002;107-111.