Defects in reproductive functions in PACAP-deficient female mice

Regulatory Peptides

Volumn 109, Issue 1-3, 2002, Pages 45-48

  Shintani, Norihito ^a   Mori, Wakaba ^a   Hashimoto, Hitoshi ^a   Imai, Masayuki ^a   Tanaka, Kazuhiro ^a   Tomimoto, Shuhei ^a   Hirose, Megumi ^a   Kawaguchi, Chihiro ^a   Baba, Akemichi ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Maternal behavior; Mating; Nursing; Pituitary adenylate cyclase activating polypeptide (PACAP); Pseudopregnancy; Sexual behavior

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE;

ARTICLE; CHILDBIRTH; CHROMOSOME PAIRING; CONTROLLED STUDY; FEMALE; FEMALE GENITAL SYSTEM; FERTILITY; MALE; MATERNAL BEHAVIOR; MATING; MOUSE; NONHUMAN; PRIORITY JOURNAL; REDUCTION; REPRODUCTION; SEXUAL BEHAVIOR; VASECTOMY; WILD TYPE;

ANIMALS; FEMALE; FERTILITY; GENE DELETION; LITTER SIZE; MATERNAL BEHAVIOR; MICE; MICE, KNOCKOUT; NEUROPEPTIDES; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; REPRODUCTION; RNA, MESSENGER; SEXUAL BEHAVIOR, ANIMAL; VAGINA;

EID: 0037111441     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(02)00169-6     Document Type: Article

References (24)

1. Arimura A. Perspectives on pituitary adenylate cyclase activating polypeptide (PACAP) in the neuroendocrine, endocrine, and nervous systems. Jpn. J. Physiol. 48:1998;301-331.
2. Vaudry D., Gonzalez B.J., Basille M., Yon L., Fournier A., Vaudry H. Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions. Pharmacol. Rev. 52:2000;269-324.
3. Nancy M.S., Sandra L.K., John E.M. The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily. Endocr. Rev. 21:2000;619-670.
4. Miyata A., Jian L., Dahl R.R., Minamino N., Uehara A., Jiang L.et al. Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem. Biophys. Res. Commun. 164:1989;567-574.
5. Culler M.D., Paschall C.S. Pituitary adenylate cyclase activating polypeptide (PACAP) potentiates the gonadotropin-releasing activity of luteinizing hormone-releasing hormone. Endocrinology. 129:1991;2260-2262.
6. Kotani E., Usuki S., Kubo T. Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on progestin biosynthesis in cultured granulosa cells from rat ovary and expression of mRNA encoding PACAP type IA receptor. J. Reprod. Fertil. 112:1998;107-114.
7. Gras S., Hannibal J., Fahrenkrug J. Pituitary adenylate cyclase-activating polypeptide is an auto/paracrine stimulator of acute progesterone accumulation and subsequent luteinization in cultured periovulatory granulosa/lutein cells. Endocrinology. 140:1999;2199-2205.
8. Hashimoto H., Shintani N., Nishino A., Okabe M., Ikawa M., Matsuyama S.et al. Mice with markedly reduced PACAP (PAC(1)) receptor expression by targeted deletion of the signal peptide. J. Neurochem. 75:2000;1810-1817.
9. 1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. J. Clin. Invest. 105:2000;1307-1315.
10. Otto C., Kovalchuk Y., Wolfer D.P., Gass P., Martin M., Zuschratter W.et al. Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient mice. J. Neurosci. 21:2001;5520-5527.
11. 1 null females display decreased fertility. Ann. N.Y. Acad. Sci. 921:2000;400-404.
12. Hashimoto H., Shintani N., Tanaka K., Mori W., Hirose M., Matsuda T.et al. Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Proc. Natl. Acad. Sci. U. S. A. 98:2001;13355-13360.
13. Gray S.L., Cummings K.J., Jirik F.R., Sherwood N.M. Targeted disruption of the pituitary adenylate cyclase-activating polypeptide gene results in early postnatal death associated with dysfunction of lipid and carbohydrate metabolism. Mol. Endocrinol. 15:2001;1739-1747.
14. Hamelink C., Tjurmina O., Damadzic R., Young W.S., Weihe E., Lee H.W.et al. Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Proc. Natl. Acad. Sci. U. S. A. 99:2002;461-466.
15. Brown J.R., Ye H., Bronson R.T., Dikkes P., Greenberg M.E. A defect in nurturing in mice lacking the immediate early gene fosB. Cell. 86:1996;297-309.
16. Skoglosa Y., Takei N., Lindholm D. Distribution of pituitary adenylate cyclase activating polypeptide mRNA in the developing rat brain. Brain Res. Mol. Brain Res. 65:1999;1-13.
17. Hashimoto H., Nogi H., Mori K., Ohishi H., Shigemoto R., Yamamoto K.et al. Distribution of the mRNA for a pituitary adenylate cyclase-activating polypeptide receptor in the rat brain: an in situ hybridization study. J. Comp. Neurol. 371:1996;567-577.
18. Shioda S., Shuto Y., Somogyvari-Vigh A., Legradi G., Onda H., Coy D.H.et al. Localization and gene expression of the receptor for pituitary adenylate cyclase-activating polypeptide in the rat brain. Neurosci. Res. 28:1997;345-354.
19. Usdin T.B., Bonner T.I., Mezey E. Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions. Endocrinology. 135:1994;2662-2680.
20. Daniels D., Miselis R.R., Flanagan-Cato L.M. Central neuronal circuit innervating the lordosis-producing muscles defined by transneuronal transport of pseudorabies virus. J. Neurosci. 19:1999;2823-2833.
21. Terkel J. Neuroendocrine processes in the establishment of pregnancy and pseudopregnancy in rats. Psychoneuroendocrinology. 13:1988;5-28.
22. Ormandy C.J., Camus A., Barra J., Damotte D., Lucas B., Buteau H.et al. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 11:1997;167-178.
23. Yi S.E., LaPolt P.S., Yoon B.S., Chen J.Y., Lu J.K., Lyons K.M. The type I BMP receptor BmprIB is essential for female reproductive function. Proc. Natl. Acad. Sci. U. S. A. 98:2001;7994-7999.
24. Deviterne D., Desor D., Krafft B. Maternal behavior variations and adaptations, and pup development within litters of various sizes in Wistar rat. Dev. Psychobiol. 23:1990 May;349-360.