Protein kinase C inhibitors counteract the ethanol effects on myelin basic protein expression in differentiating CG-4 oligodendrocytes

Developmental Brain Research

Volumn 139, Issue 1, 2002, Pages 29-38

  Bichenkov, Evgeny ^a   Ellingson, John S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Differentiation; Ethanol; Fetal alcohol syndrome; Myelin basic protein; Oligodendrocyte; Protein kinase C isozyme

Indexed keywords

ALCOHOL; BISINDOLYLMALEIMIDE; CALPHOSTIN C; CHELERYTHRINE; ISOENZYME; PHORBOL 12 ACETATE 13 MYRISTATE; PHORBOL DERIVATIVE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEVELOPMENTAL STAGE; DOWN REGULATION; ENZYME INHIBITION; FETUS; MORPHOLOGY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

CELL DIFFERENTIATION; CELL LINE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; ETHANOL; HUMANS; IMMUNOBLOTTING; MYELIN BASIC PROTEINS; OLIGODENDROGLIA; PROTEIN KINASE C; TETRADECANOYLPHORBOL ACETATE;

EID: 0037111109     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(02)00512-6     Document Type: Article

References (50)

1. Acevedo-Duncan M., Pearlman J., Zachariah B. Sensitivity of human glioma U-373MG cells to radiation and the protein kinase C inhibitor, calphostin C. Cell Prolif. 34:2001;31-41.
2. Anderson S., Miskimins R. Involvement of protein kinase C in cAMP regulation of myelin basic protein gene expression. J. Neurosci. Res. 37:1994;604-611.
3. Asotra K., Macklin W.B. Protein kinase C activity modulates myelin gene expression in enriched oligodendrocytes. J. Neurosci. Res. 34:1993;571-588.
4. Asotra K., Macklin W.B. Developmental expression of protein kinase C isozymes in oligodendrocytes and their differential modulation by 4 beta-phorbol-12,13-dibutyrate. J. Neurosci. Res. 39:1994;273-289.
5. Avossa D., Pfeiffer S.E. Transient reversion of O4+. J. Neurosci. Res. 34:1993;113-128.
6. Baron W., de Jonge J.C., de Vries H., Hoekstra D. Regulation of oligodendrocyte differentiation: protein kinase C activation prevents differentiation of O2A progenitor cells toward oligodendrocytes. Glia. 22:1998;121-129.
7. Baron W., de Jonge J.C., de Vries H., Hoekstra D. Perturbation of myelination by activation of distinct signaling pathways: an in vitro study in a myelinating culture derived from fetal rat brain. J. Neurosci. Res. 59:2000;74-85.
8. Baron W., de Vries E.J., de Vries H., Hoekstra D. Protein kinase C prevents oligodendrocyte differentiation: modulation of actin cytoskeleton and cognate polarized membrane traffic. J. Neurobiol. 41:1999;385-398.
9. Bhat N.R., Zhang P. Activation of mitogen-activated protein kinases in oligodendrocytes. J. Neurochem. 66:1996;1986-1994.
10. Bichenkov E., Ellingson J.S. Temporal and quantitative expression of the myelin-associated lipids, ethanolamine plasmalogen, galactocerebroside, and sulfatide, in the differentiating CG-4 glial cell line. Neurochem. Res. 24:1999;1549-1556.
11. Bichenkov E., Ellingson J.S. Effects of transient ethanol exposure on the incorporation of [(3)H]ethanolamine into plasmalogen in the differentiating CG-4 oligodendrocyte cell line. Biochem. Pharmacol. 60:2000;1703-1711.
12. Bichenkov E., Ellingson J.S. Ethanol exerts different effects on myelin basic protein and 2′,3′-cyclic nucleotide 3′-phosphodiesterase expression in differentiating CG-4 oligodendrocytes. Dev. Brain Res. 128:2001;9-16.
13. Bruns R.F., Miller F.D., Merriman R.L., Howbert J.J., Heath W.F., Kobayashi E., Takahashi I., Tamaoki T., Nakano H. Inhibition of protein kinase C by calphostin C is light-dependent. Biochem. Biophys. Res. Commun. 176:1991;288-293.
14. Chiappelli F., Taylor A.N., Espinosa de los M.A., De Vellis J. Fetal alcohol delays the developmental expression of myelin basic protein and transferrin in rat primary oligodendrocyte cultures. Int. J. Dev. Neurosci. 9:1991;67-75.
15. Clark E.A., Leach K.L., Trojanowski J.Q., Lee V.M. Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains. Lab. Invest. 64:1991;35-44.
16. Dempsey E.C., Newton A.C., Mochly-Rosen D., Fields A.P., Reyland M.E., Insel P.A., Messing R.O. Protein kinase C isozymes and the regulation of diverse cell responses. Am. J. Physiol. Lung Cell. Mol. Physiol. 279:2000;L429-L438.
17. Domenicotti C., Paola D., Vitali A., Nitti M., Cottalasso D., Pronzato M.A., Poli G., Melloni E., Marinari U.M. Ethanol-induced effects on expression level, activity, and distribution of protein kinase C isoforms in rat liver Golgi apparatus. Chem. Biol. Interact. 114:1998;33-43.
18. Gschwendt M.S., Dieterich S., Rennecke J., Kittstein W., Mueller H.J., Johannes F.J. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 392:1996;77-80.
19. Herbert J.M., Augereau J.M., Gleye J., Maffrand J.P. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 172:1990;993-999.
20. Hofmann J. The potential for isoenzyme-selective modulation of protein kinase C. FASEB J. 11:1997;649-669.
21. Kimura M., Sato M., Akatsuka A., Nozawa-Kimura S., Takahashi R., Yokoyama M., Nomura T., Katsuki M. Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice. Proc. Natl. Acad. Sci. USA. 86:1989;5661-5665.
22. Kobayashi E., Nakano H., Morimoto M., Tamaoki T. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 159:1989;548-553.
23. Kojima H., Mineta-Kitajima R., Saitoh-Harada N., Kurihara T., Takahashi Y., Furudate S., Shirataka M., Nakamura K., Tamai Y. Prenatal ethanol exposure affects the activity and mRNA expression of neuronal membrane enzymes in rat offspring. Life Sci. 55:1994;1433-1442.
24. Kraft A.S., Anderson W.B. Characterization of cytosolic calcium-activated phospholipid-dependent protein kinase activity in embryonal carcinoma cells. Effect of retinoc acid-induced differentiation of F9 cells to parietal endoderm. J. Biol. Chem. 258:1983;9178-9183.
25. Lancaster F.E. Alcohol and white matter development - a review. Alcohol Clin. Exp. Res. 18:1994;644-647.
26. Louis J.C., Magal E., Muir D., Manthorpe M., Varon S. CG-4, a new bipotential glial cell line from rat brain, is capable of differentiating in vitro into either mature oligodendrocytes or type-2 astrocytes. J. Neurosci. Res. 31:1992;193-204.
27. Mahadev K., Vemuri M.C. Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Arch. Biochem. Biophys. 356:1998;249-257.
28. Martiny-Baron G., Kazanietz M.G., Mischak H., Blumberg P.M., Kochs G., Hug H., Marme D., Schachtele C. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J. Biol. Chem. 268:1993;9194-9197.
29. McIntyre T.A., Souder M.G., Hartl M.W., Shibley I.A. Ethanol-induced decrease of developmental PKC isoform expression in the embryonic chick brain. Brain Res. Dev. Brain Res. 117:1999;191-197.
30. Messing R.O., Petersen P.J., Henrich C.J. Chronic ethanol exposure increases levels of protein kinase C delta and epsilon and protein kinase C-mediated phosphorylation in cultured neural cells. J. Biol. Chem. 266:1991;23428-23432.
31. Mochly-Rosen D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science. 268:1995;247-251.
32. 2+-dependent protein kinase C isoforms induced by chronic ethanol treatment in mice. Neurosci. Lett. 307:2001;85-88.
33. Nishizuka Y. Studies and prospectives of the protein kinase c family for cellular regulation. Cancer. 63:1989;1892-1903.
34. Ogiwara T., Negishi T., Chik C.L., Ho A.K. Differential effects of two protein kinase C inhibitors, calphostin C and Go6976, on pineal cyclic nucleotide accumulation. J. Neurochem. 71:1998;1405-1412.
35. Phillips D.E. Effects of alcohol on the development of glial cells and myelin. Watson R.R., Alcohol and Neurobiology. Brain Development and Hormone Regulation. 1992;83-108 CRC Press, Boca Raton, FL.
36. Pouly S., Matthieu J.M., Honegger P. Remyelination in vitro following protein kinase C activator-induced demyelination. Neurochem. Res. 26:2001;619-627.
37. Readhead C., Popko B., Takahashi N., Shine H.D., Saavedra R.A., Sidman R.L., Hood L. Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Cell. 48:1987;703-712.
38. Ron D., Vagts A.J., Dohrman D.P., Yaka R., Jiang Z., Yao L., Crabbe J., Grisel J.E., Diamond I. Uncoupling of betaIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain. FASEB J. 14:2000;2303-2314.
39. Schonwasser D.C., Marais R.M., Marshall C.J., Parker P.J. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell Biol. 18:1998;790-798.
40. Sperber B.R., Boyle-Walsh E.A., Engleka M.J., Gadue P., Peterson A.C., Stein P.L., Scherer S.S., McMorris F.A. A unique role for Fyn in CNS myelination. J. Neurosci. 21:2001;2039-2047.
41. Stariha R.L., Kikuchi S., Siow Y.L., Pelech S.L., Kim M., Kim S.U. Role of extracellular signal-regulated protein kinases 1 and 2 in oligodendroglial process extension. J. Neurochem. 68:1997;945-953.
42. Stariha R.L., Kim S.U. Mitogen-activated protein kinase signalling in oligodendrocytes: a comparison of primary cultures and CG-4. Int. J. Dev. Neurosci. 19:2001;427-437.
43. Stariha R.L., Kim S.U. Protein kinase C and mitogen-activated protein kinase signalling in oligodendrocytes. Microsc. Res. Tech. 52:2001;680-688.
44. Streissguth A.P., Aase J.M., Clarren S.K., Randels S.P., LaDue R.A., Smith D.F. Fetal alcohol syndrome in adolescents and adults [see comments]. J. Am. Med. Assoc. 265:1991;1961-1967.
45. Stubbs C.D., Slater S.J. Ethanol and protein kinase C. Alcohol Clin. Exp. Res. 23:1999;1552-1560.
46. Toullec D., Pianetti P., Coste H., Bellevergue P., Grand-Perret T., Ajakane M., Baudet V., Boissin P., Boursier E., Loriolle F. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266:1991;15771-15781.
47. Umemori H., Kadowaki Y., Hirosawa K., Yoshida Y., Hironaka K., Okano H., Yamamoto T. Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination. J. Neurosci. 19:1999;1393-1397.
48. Way K.J., Chou E., King G.L. Identification of PKC-isoform-specific biological actions using pharmacological approaches. Trends Pharmacol. Sci. 21:2000;181-187.
49. Yong V.W., Dooley N.P., Noble P.G. Protein kinase C in cultured adult human oligodendrocytes: a potential role for isoform alpha as a mediator of process outgrowth. J. Neurosci. Res. 39:1994;83-96.
50. Zoeller R.T., Butnariu O.V., Fletcher D.L., Riley E.P. Limited postnatal ethanol exposure permanently alters the expression of mRNAS encoding myelin basic protein and myelin-associated glycoprotein in cerebellum. Alcohol Clin. Exp. Res. 18:1994;909-916.