Applications of quantitative digital image analysis to breast cancer research

Microscopy Research and Technique

Volumn 59, Issue 2, 2002, Pages 119-127

  Ortiz De Solorzano C ^a   Costes, S ^a   Callahan, D E ^a   Parvin, B ^a   Barcellos Hoff, M H ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Carcinogenesis; Genomic instability; Ionizing radiation; Mammary gland; Transforming growth factor

Indexed keywords

CYTOLOGY; DISEASES; GENES; IONIZING RADIATION; MAMMALS; MEDICAL IMAGING; PATHOLOGY; PROBES;

BREAST CANCER; CARCINOGENESES; GENOMIC INSTABILITY; HUMAN MODELLING; IMAGE-ANALYSIS; MAMMARY GLAND; MICE MODELS; MICROENVIRONMENTS; TRANSFORMING GROWTH FACTOR-Β; TRANSFORMING GROWTH FACTORS;

IMAGE ANALYSIS;

CANCER ANTIBODY;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER RESEARCH; CANCER SUSCEPTIBILITY; CELL COMPOSITION; CELL INTERACTION; GENETIC STABILITY; IMAGE ANALYSIS; IMMUNOFLUORESCENCE; MICROENVIRONMENT; PHENOTYPE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS;

EID: 0037108629     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.10183     Document Type: Article

References (37)

1. Barcellos-Hoff MH. 1996. Latency and activation in the regulation of TGF-β. J Mammary Gland Biol Neoplas 3:353-363.
2. Barcellos-Hoff MH. 1998. How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues. Radiation Res 150:S109-S120.
3. Barcellos-Hoff MH, Bissell MJ. 1989. Mammary epithelial cells as a model for studies of the regulation of gene expression. Functional epithelial cells in culture. New York: Alan R. Liss, Inc. p 399-433.
4. Barcellos-Hoff MH, Brooks AL. 2001. Extracellular signaling via the microenvironment: A hypothesis relating carcinogenesis, bystander effects and genomic instability. Radiat Res 156:618-627.
5. Barcellos-Hoff MH, Ewan KB. 2000. TGF-β and mammary gland development. Breast Cancer Res 2:92-100.
6. Barcellos-Hoff MH, Ravani SA. 2000. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res 60:1254-1260.
7. Barcellos-Hoff MH, Aggeler J, Ram TG, Bissell MJ. 1989. Functional differentiation and alveolar morphogenesis of primary mammary epithelial cells cultures on reconstituted basement membrane. Development 105:223-235.
8. Barcellos-Hoff MH, Derynck R, Tsang ML-S, Weatherbee JA. 1994. Transforming growth factor-β activation in irradiated murine mammary gland. J Clin Invest 93:892-899.
9. Bissell MJ. 1981. The differentiated state of normal and malignant cells or how to define a "normal" cell in culture. Int Rev Cytol 70:27-100.
10. Bissell MJ, Barcellos-Hoff MH. 1987. The influence of extracellular matrix on gene expression: Is structure the message? J Cell Sci 8:327-343.
11. Bissell MJ, Weaver VM, Lelièvre SA, Wang F, Petersen OW, Schmeichel KL. 1999. Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Res 59 (Suppl 7):1757-1763s; discussion 1763s-1764s.
12. Ortiz de Solórzano C, Chin K, Knowles D, Jones A, Garcia E, Gray JW, Lockett SJ. 1999. 3D confocal microscopy and image analysis for measurement of genetic instability. Microscopy and Microanalysis 5(s2):1022-1023.
13. Cong G, Parvin B (2000). A new regularized approach for contour morphing. Proceedings of IEEE Conference on Computer Vision and Pattern Recognition, Los Alamitos, CA. 1:458-463.
14. Costes SV, Streuli CH, Barcellos-Hoff MH. 2000. Quantitative image analysis of laminin immunoreactivity in 1 GeV/amu iron particle irradiated skin basement membrane. Radiat Res 154:389-397.
15. Davis FG, Boice JD, Hrubec Z, Monson RR. 1989. Cancer mortality in a radiation-exposed cohort of massachusetts tuberculosis patients. Can Res 49:6130-6136.
16. Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V. 1997. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science 277:225-228.
17. Harris CC. 1987. Human tissues and cells in carcinogenesis research. Cancer Res 47:1-10.
18. Lewko W, Liotta LA, Wicha MS, Vonderhaar BK, Kidwell WR. 1981. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res 41:2855-2862.
19. Liotta LA, Rao CN, Barsky SH. 1983. Tumor invasion and the extracellular matrix. Lab Invest 49:636-649.
20. Mattsson A, Ruden B-I, Wilking N, Rutqvist LE. 1993. Radiationinduced breast cancer: long-term follow-up of radiation therapy for benign breast disease. J Natl Cancer Inst 85:1679-1685.
21. Mauch P. 1995. Second malignancies after curative radiation therapy for good prognosis cancers. Int J Radiat Oncol Biol Phys 33:959-960.
22. Miyazono K, Heldin C-H (1991). Latent forms of TGF-β: molecular structure and mechanisms of activation. In: Bock GR, Marsh J, editors. Clinical applications of TGF-β. Chichester: John Wiley. 157:81-92.
23. Montgomery AM, Reisfeld RA, Cheresh DA. 1994. Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc Natl Acad Sci USA 91:8856-8860.
24. Nettesheim P, Barrett JC. 1985. In vitro transformation of rat tracheal epithelial cells: a model for the study of multistage carcinogenesis. Carcinog Compr Surv 9:283-291.
25. Ortiz de Solórzano C, Garcia Rodriguez E, Jones A, Pinkel D, Gray JW, Sudar D, Lockett SJ. 1999. Segmentation of confocal microscope images of cell nuclei in thick tissue sections. J Microsc 193: 212-226.
26. Ortiz de Solórzano C, Malladi R, Lelievre S, Lockett SJ. 2001. Segmentation of nuclei and cells using membrane related protein markers. J Microsc 201:404-415.
27. Parvin B, Taylor J, Cong G, O'Keefe MA, Barcellos-Hoff MH. DeepView: A channel for distributed microscopy and informatics. In: Proceedings of the ACM/IEEE SCC99 Conference on High Performance Networking and Computing, Portland, OR, 14-19 November 1999, p 15.
28. Parvin B, Yang Q, Fontenay G, Henshall R, Barcellos-Hoff MH. 2000. BioSig: an imaging bioinformatic system for studying phenomics. IEEE Computer, 35:65-71.
29. Petersen OW, Ronnov-Jessen L, Howlett AR, Bissell MJ. 1992. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci USA 89:9064-9068.
30. Roberts AB, Thompson NL, Heine U, Flanders C, Sporn MB. 1988. Transforming growth factor-beta: possible roles in carcinogenesis. Br J Cancer 57:594-600.
31. Roskelley CD, Srebrow A, Bissell MJ. 1995. A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression. Curr Op Cell Biol 7:736-747.
32. Shyamala G, Barcellos-Hoff MH, Toft D, Yang X. 1997. In situ localization of progesterone receptors in normal mouse mammary glands: absence of receptors in the connective and adipose stroma and a heterogeneous distribution in the epithelium. J Steroid Biochem Mol Biol 63:251-259.
33. Siegal GP, Barsky SH, Terranova VP, Liotta LA. 1981. Stages of neoplastic transformation of human breast tissue as monitored by dissolution of basement membrane components. An immunoperoxidase study. Invas Metast 1:54-70.
34. Stack MS, Gray RD, Pizzo SV. 1993. Modulation of murine B16F10 melanoma plasminogen activator production by a synthetic peptide derived from the laminin A chain. Cancer Res 53:1998-2004.
35. Tlsty TD. 1998. Cell-adhesion-dependent influences on genomic instability and carcinogenesis. Curr Opin Cell Biol 10:647-653.
36. Tokunaga M, Land C, Tokuoka S. 1991. Follow-up studies of breast cancer incidence among atomic bomb survivors. J Rad Res Suppl 32:201-211.
37. Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ. 1997. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 137:231-245.