Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand contact to engineer a less immunogenic humanized monoclonal antibody

Journal of Immunology

Volumn 169, Issue 6, 2002, Pages 3076-3084

  De Pascalis, Roberto ^a   Iwahashi, Makoto ^a   Tamura, Midori ^a   Padlan, Eduardo A ^a   Gonzales, Noreen R ^a   Santos, Ameurfina D ^a   Giuliano, Mariateresa ^a   Schuck, Peter ^a   Schlom, Jeffrey ^a   Kashmiri, Syed V S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; LIGAND; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY COL 1; REAGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY ENGINEERING; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CARCINOMA; COMPLEMENTARITY DETERMINING REGION; HUMAN; IMMUNOGENICITY; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SERUM; TUMOR LOCALIZATION;

EID: 0037105591     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.6.3076     Document Type: Article

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