Plasminogen activator-plasmin system potentiates the proliferation of hepatocytes in primary culture

Thrombosis Research

Volumn 107, Issue 3-4, 2002, Pages 169-174

  Akao, Makoto ^a   Hasebe, Yuichi ^a   Okumura, Nobuaki ^a   Hagiwara, Hiromi ^a   Seki, Taiichiro ^a   Ariga, Toyohiko ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Hepatocyte; Liver; Plasmin; Tissue type plasminogen activator (tPA); Urokinase type plasminogen activator (uPA)

Indexed keywords

AGAROSE; COLLAGENASE; FIBRIN; MESSENGER RNA; N (4 AMINOMETHYLBENZOYL) 4 (3 PICOLYLOXY)PHENYLALANINE HEXYLAMIDE; PASI 535; PLASMIN; PLASMIN INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; THYMIDINE; TISSUE PLASMINOGEN ACTIVATOR; TRANEXAMIC ACID; UNCLASSIFIED DRUG; UROKINASE; DNA; PLASMINOGEN; PLASMINOGEN ACTIVATOR;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL ISOLATION; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; DNA SYNTHESIS; DOSE RESPONSE; DRUG ACTIVITY; DRUG POTENCY; ENZYME ACTIVITY; GENE EXPRESSION; LIVER CELL CULTURE; LIVER PERFUSION; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; ANIMAL; BIOSYNTHESIS; CELL DIVISION; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; LIVER CELL; LIVER REGENERATION; PHYSIOLOGY; WISTAR RAT;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DIVISION; DNA; GENE EXPRESSION REGULATION; HEPATOCYTES; LIVER REGENERATION; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATORS; RATS; RATS, WISTAR; RNA, MESSENGER; TISSUE PLASMINOGEN ACTIVATOR; URINARY PLASMINOGEN ACTIVATOR;

EID: 0037104685     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(02)00258-X     Document Type: Article

References (27)

1. Fausto N., Laird A., Webber E.M. Liver regeneration: 2. Role of growth factors and cytokines in hepatic regeneration. FASEB J. 9(15):1995;1527-1536.
2. Yamada Y., Webber E.M., Kirillova I., Peschon J.J., Fausto N. Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor. Hepatology. 28(4):1998;906-913.
3. Haruyama T., Ajioka I., Akaike T., Watanabe Y. Regulation and significance of hepatocyte-derived matrix metalloproteinases in liver remodeling. Biochem. Biophys. Res. Commun. 272(3):2000;681-686.
4. Kim T.H., Mars M.W., Stolz D.B., Petersen B.E., Michalopoulos G.K. Extracellular matrix remodeling at the early stages of liver regeneration in the rat. Hepatology. 26(4):1997;896-904.
5. Rudolph K.L., Trautwein C., Kubicka S., Rakemann T., Bahr M.J., Sedlaczek N.et al. Differential regulation of extracellular matrix synthesis during liver regeneration after partial hepatectomy in rats. Hepatology. 30(5):1999;1159-1166.
6. Michalopoulos G.K., DeFrances M.C. Liver regeneration. Science. 276(5309):1997;60-66.
7. Mars W.M., Kim T.H., Stolz D.B., Liu M.L., Michalopoulos G.K. Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor. Cancer Res. 56(12):1996;2837-2843.
8. Bisgaard H.C., Santoni-Rugiu E., Nagy P., Thorgeirsson S.S. Modulation of the plasminogen activator/plasmin system in rat liver regenerating by recruitment of oval cells. Lab. Invest. 78(3):1998;237-246.
9. Mayer M. Biochemical and biological aspects of the plasminogen activation system. Clin. Biochem. 23(3):1990;197-211.
10. Sappino A.P., Wohlwend A., Huarte J., Belin D., Vassalli J.D. The PA-plasmin system during murine embryogenesis. Ann. N. Y. Acad. Sci. 667:1992;41.
11. Baramova E.N., Bajon K., Remacle A., L'Hoir C., Krell H.W., Weidle U.H.et al. Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation. FEBS Lett. 405(2):1997;157-162.
12. Mars W.M., Liu M.L., Kitson R.P., Goldfarb R.H., Gabauer M.K., Michalopoulos G.K. Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration. Hepatology. 21(6):1995;1695-1701.
13. Thornton A.J., Bruzdzinski C.J., Raper S.E., Gelehrter T.D. Plasminogen activator inhibitor-1 is an immediate early response gene in regenerating rat liver. Cancer Res. 54(5):1994;1337-1343.
14. Uno S., Nakamura M., Seki T., Ariga T. Induction of tissue-type plasminogen activator (tPA) and type-1 plasminogen activator inhibitor (PAI-1) as early growth responses in rat hepatocytes in primary culture. Biochem. Biophys. Res. Commun. 239(1):1997;123-128.
15. Ichihara A., Nakamura T., Tanaka K., Tomita Y., Aoyama K., Kato S.et al. Biochemical functions of adult rat hepatocytes in primary culture. Ann. N. Y. Acad. Sci. 349:1980;77-84.
16. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162(1):1987;156-159.
17. Noguchi T., Noguchi M., Masubuchi H., Seki T., Ariga T. Il-1β down-regulates tissue-type plasminogen activator by up-regulating low-density lipoprotein receptor-related protein in AML 12 cells. Biochem. Biophys. Res. Commun. 288(1):2001;42-48.
18. Rijken D.C., Wijngard G., Welbergen J. Immunological characterization of plasminogen activator activities in human tissues and body fluids. J. Lab. Clin. Med. 97(4):1981;477-486.
19. Heussen C., Dowdle E. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal. Biochem. 102(1):1980;196-202.
20. Deutsch D.G., Mertz E. Plasminogen: purification from human plasma by affinity chromatography. Science. 170(962):1970;1095-1096.
21. Hurn B.A., Chantler S. Production of reagent antibodies. Methods Enzymol. 70:1980;104-142.
22. Hamada T., Kato Y., Terasaki T., Sugiyama Y. Cell density-dependent mitogenic effect and -independent cellular handling of epidermal growth factor in primary cultured rat hepatocytes. J. Hepatol. 26(2):1997;353-360.
23. Bezerra J.A., Bugge T.H., Melin-Aldana H., Sabla G., Kombrinck K.W., Witte D.P.et al. Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver. Proc. Natl. Acad. Sci. U. S. A. 96(26):1999;15143-15148.
24. Bezerra J.A., Currier A.R., Melin-Aldana H., Sabla G., Bugge T.H., Kombrinck K.W.et al. Plasminogen activators direct reorganization of the liver lobule after acute injury. Am. J. Pathol. 158(3):2001;921-929.
25. Matsumoto A., Yamamoto N. Sequention of hepatocyte growth factor in extracellular matrix in normal adult rat liver. Biochem. Biophys. Res. Commun. 174:1991;90-95.
26. Shimizu M., Hara A., Okuno M., Matsuno H., Okada K., Ueshima S.et al. Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic apoptosis. Hepatology. 33(3):2001;569-576.
27. Noguchi T., Matsuyama S., Akao M., Hagiwara H., Uno S., Seki T.et al. Induction of hepatic tissue-type plasminogen activator and type 1 plasminogen activator-inhibitor gene expressions and appearance of their translation products in the bile following acute liver injury in rats. Thromb. Res. 104(4):2001;283-291.