Biosensor detection of triplex formation by modified oligonucleotides

Analytical Biochemistry

Volumn 307, Issue 2, 2002, Pages 235-243

  Bates, Paula J ^a   Reddoch, James F ^b   Hansakul, Pintusorn ^b   Arrow, Amy ^c   Dale, Roderic ^c   Miller, Donald M ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c Oligos Etc Inc   (United States)

Author keywords

Biomolecular interaction analysis; Oligonucleotide; Surface plasmon resonance; Triplex

Indexed keywords

BIOSENSORS; GENE EXPRESSION; PLASMONS; RNA; SURFACE PLASMON RESONANCE;

BIOLOGICAL SOLUTIONS; BIOMOLECULAR INTERACTION ANALYSIS; DNA OLIGONUCLEOTIDES; EXPERIMENTAL CONDITIONS; MODIFIED OLIGONUCLEOTIDES; NON-SPECIFIC INTERACTIONS; SURFACE PLASMON RESONANCE BIOSENSOR; TRIPLEX;

OLIGONUCLEOTIDES;

DEOXYRIBONUCLEASE; OLIGONUCLEOTIDE; PYRIMIDINE;

ARTICLE; BIOSENSOR; CHEMICAL BINDING; DNA FOOTPRINTING; GENE TARGETING; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROMOTER REGION; SURFACE PLASMON RESONANCE;

MURINAE;

EID: 0037102330     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2697(02)00063-5     Document Type: Article

References (47)

1. Triplex-forming oligonucleotides and their use in the analysis of gene transcription
2. Triplex-forming molecules for modulation of DNA information processing
3. Gene targeting via triple-helix formation
4. Recent developments in triple-helix regulation of gene expression
5. Specific mutations induced by triplex-forming oligonucleotides in mice
6. Self-association of G-rich oligodeoxyribonucleotides under conditions promoting purine-motif triplex formation
7. Guanine-rich oligonucleotides targeted to a critical R. Y site located in the Ki-ras promoter. The effect of competing self-structures on triplex formation
8. Effect of competing self-structure on triplex formation with purine-rich oligodeoxynucleotides containing GA repeats
9. Phosphorothioate antisense oligodeoxynucleotides: Questions of specificity
10. Triple helix formation with purine-rich phosphorothioate-containing oligonucleotides covalently linked to an acridine derivative
11. Inhibition of T7 RNA polymerase transcription by phosphate and phosphorothioate triplex-forming oligonucleotides targeted to a R.Y site downstream from the promoter
12. Pyrimidine phosphorothioate oligonucleotides form triple-stranded helices and promote transcription inhibition
13. Phosphorothioate oligonucleotide-directed triple helix formation
14. Synthetic repeating sequence DNAs containing phosphorothioates: Nuclease sensitivity and triplex formation
15. Highly efficient chemical synthesis of 2′-O-methyloligoribonucleotides and tetrabiotinylated derivatives; novel probes that are resistant to degradation by RNA or DNA specific nucleases
16. 2′-O-alkyl oligoribonucleotides as antisense probes
17. Inhibition of transcription of the human c-myc protooncogene by intermolecular triplex
18. Inhibition of in vitro transcription by a triplex-forming oligonucleotide targeted to human c-myc P2 promoter
19. Inhibition of nuclear protein binding to two sites in the murine c-myc promoter by intermolecular triplex formation
20. A unique c-myc-targeted triplex-forming oligonucleotide inhibits the growth of ovarian and cervical carcinomas in vitro
21. Myc function and regulation
22. Regulation of c-myc transcription initiation and elongation
23. Molecular requirements for transcriptional initiation of the murine c-myc gene
24. Three distinct elements within the murine c-myc promoter are required for transcription
25. MAZ, a zinc finger protein, binds to c-myc and C2 gene sequences regulating transcription initiation and termination
26. How to design an antisense oligodeoxynucleotide experiment: A consensus approach
27. Antiproliferative activity of G-rich oligonucleotides correlates with protein binding
28. The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism
29. Formation of a G-tetrad and higher order structures correlates with biological activity of the RelA (NF-kappaB p65) 'antisense' oligodeoxynucleotide
30. Detection and kinetic studies of triplex formation by oligodeoxynucleotides using real-time biomolecular interaction analysis (BIA)
31. pH and cation effects on the properties of parallel pyrimidine motif dna triplexes
32. Thermodynamic and kinetic effects of N3′ → P5′ phosphoramidate modification on pyrimidine motif triplex DNA formation
33. Triplex formation of chemically modified homopyrimidine oligonucleotides: Thermodynamic and kinetic studies
34. Polyl (L-lysine)-graft-dextran copolymer promotes pyrimidine motif triplex DNA formation at physiological pH. Thermodynamic and kinetic studies
35. Thermodynamic kinetic and conformational properties of a parallel intermolecular DNA triplex containing 5′ and 3′ junctions
36. Effect of chemical modification of oligohomopyrimidine on triplex formation: Thermodynamic and kinetic studies
37. Surface plasmon resonance for real-time monitoring of molecular interactions between a triple helix forming oligonucleotide and the Sp1 binding sites of human Haras promoter: Effects of the DNA-binding drug chromomycin
38. Targeting of the HIV-1 long terminal repeat with chromomycin potentiates the inhibitory effects of a triplex-forming oligonucleotide on Sp1-DNA interactions and in vitro transcription
39. Comparative stability of eight different triple helices formed by differently modified DNA or RNA pyrimidine strands and a DNA hairpin
40. Single-stranded DNA and RNA targeted triplex-formation: UV, CD and molecular modeling studies of foldback triplexes containing different RNA, 2′-OMe-RNA and DNA combinations
41. Relative stabilities of triple helices composed of combinations of DNA, RNA and 2′-O-methyl-RNA backbones: Chimeric circular oligonucleotides as probes
42. Stability of triple helices containing RNA and DNA strands: Experimental and molecular modeling studies
43. Stability and properties of double and triple helices: Dramatic effects of RNA or DNA backbone composition
44. Stable triple helices are formed upon binding of RNA oligonucleotides and their 2′-O-methyl derivatives to double-helical DNA
45. Oligo(2′-O-methyl)ribonucleotides. Effective probes for duplex DNA
46. Exclusion of RNA strands from a purine motif triple helix
47. Poly(L-lysine)-graft-dextran copolymer: Amazing effects on triplex stabilization under physiological pH and ionic conditions (in vitro)