The expression pattern of c-mpl in megakaryocytes correlates with thrombotic risk in essential thrombocythemia

Blood

Volumn 100, Issue 2, 2002, Pages 714-717

  Teofili, Luciana ^a,b   Pierconti, Francesco ^a,b   Di Febo, Annalaura ^a,b   Maggiano, Nicola ^a,b   Vianelli, Nicola ^a,b   Ascani, Stefano ^a,b   Rossi, Elena ^a,b   Pileri, Stefano ^a,b   Leone, Giuseppe ^a,b   Larocca, Luigi Maria ^a,b   De Stfano, Valrio ^a,b  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MEGAKARYOCYTE; PRIORITY JOURNAL; PROTOONCOGENE C MPL; RISK; THROMBOCYTOSIS; THROMBOSIS; THROMBOTIC THROMBOCYTOPENIC PURPURA;

EID: 0037100542     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V100.2.714     Document Type: Article

References (23)

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4. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
5. Thrombocytopenia in c-mpl-deficient mice
6. Pathogenetic mechanisms in chronic myeloproliferative disorders: Polycythemia vera, essential thrombocythemia, agnogenic myeloid metaplasia, and chronic myelogenous leukemia
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8. Signal transduction in platelets from patients with polycythemia vera
9. Posttranslational processing of the thrombopoietin receptor is impaired in polycythemia vera
10. Immunohistochemical staining for megakaryocyte c-mpl may complement morphologic distinction between polycythemia vera and secondary erythrocytosis
11. Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia
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13. The platelet thrombopoietin receptor number and function are markedly decreased in patients with essential thrombocythaemia
14. Megakaryocyte c-mpl expression in chronic myeloproliferative disorders and the myelodysplastic syndrome: Immunoperoxidase staining patterns and clinical correlates
15. Hematological causes of venous thrombosis in young people: High incidence of myeloproliferative disorder as underlying disease in patients with splanchnic venous thrombosis
16. Spontaneous erythroid colony formation as the clue to an underlying myeloproliferative disorder in patients with Budd-Chiari syndrome or portal vein thrombosis
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19. Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice
20. Clonality analysis of hematopoiesis in essential thrombocythemia: Advantages of studying T lymphocytes and platetets
21. A large proportion of patients with a diagnosis of essential thrombocythemia do not have a clonal disorder and may be at lower risk of thrombotic complications
22. Clonal hemopoiesis and risk of thrombosis in young female patients with essential thrombocythemia
23. Clinical parameters for determining when and when not to treat essential thrombocythemia