Identification of T cell epitopes on the 33-kDa fragment of Plasmodium yoelii merozoite surface protein 1 and their antibody-independent protective role in immunity to blood stage malaria

Journal of Immunology

Volumn 169, Issue 2, 2002, Pages 944-951

  Wipasa, Jiraprapa ^a   Hirunpetcharat, Chakrit ^a   Mahakunkijcharoen, Yuvadee ^a   Xu, Huji ^a   Elliott, Salenna ^a   Good, Michael F ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MEROZOITE SURFACE PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; FEMALE; INFECTION RESISTANCE; LYMPHOCYTE PROLIFERATION; MALARIA; MEROZOITE; MOUSE; MOUSE STRAIN; NONHUMAN; PLASMODIUM YOELII; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0037100506     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.2.944     Document Type: Article

References (33)

1. Epitope map and processing scheme for the 195,000-dalton surface glycoprotein of Plasmodium falciparum merozoites deduced from cloned overlapping segments of the gene
2. Processing of the precursor to the major merozoite surface antigens of Plasmodium falciparum
3. r 185,000 glycoprotein from the surface of isolated Plasmodium falciparum merozoites form an antigenic complex
4. Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria
5. Processing of the Plasmodium falciparum major merozoite surface protein-1: Identification of a 33-kilodalton secondary processing product which is shed prior to erythrocyte invasion
6. Proteolytic processing of the Plasmodium falciparum merozoite surface protein-1 produces a membrane-bound fragment containing two epidermal growth factor-like domains
7. A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibitory antibodies
8. Characteristics of the protective response of BALB/c mice immunized with a purified Plasmodium yoelii schizont antigen
9. + T cells
10. Baculovirus merozoite surface protein 1 C-terminal recombinant antigens are highly protective in a natural primate model for human Plasmodium vivax malaria
11. 19) and their role in immunity to malaria
12. A recombinant baculovirus 42-kilodalton C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 protects Aotus monkeys against malaria
13. Comparison of protection induced by immunization with recombinant proteins from different regions of merozoite surface protein 1 of Plasmodium yoelii
14. Cloning and analysis of the gene encoding the 230-kilodalton merozoite surface antigen of Plasmodium yoelii
15. Genetic regulation of protective immune response in congenic strains of mice vaccinated with a subunit malaria vaccine
16. Apoptotic deletion of Th cells specific for the 19-kDa carboxyl-terminal fragment of merozoite surface protein 1 during malaria infection
17. + T cells adoptively transferred into recipient mice after challenge with homologous parasite
18. Prolonged Th1-like response generated by a Plasmodium yoelii-specific T cell-clone allows complete clearance of infection in reconstituted mice
19. Malaria parasite-specific Th1-like T cells simultaneously reduce parasitemia and promote disease
20. Th1 and Th2 CD4+ T cell clones specific for Plasmodium chabaudi but not for an unrelated antigen protect against blood stage P. chabaudi infection
21. Plasmodium: Immunization with carboxyl-terminal regions of MSP-1 protects against homologous but not heterologous blood-stage parasite challenge
22. Stage-specific and species-specific antigens of Plasmodium vivax and Plasmodium ovale defined by monoclonal antibodies
23. Variant- and strain sirain-specific immunity in Saimiri infected with Plasmodium falciparum
24. Immune effector mechanisms in malaria
25. A carboxyl-terminal fragment of Plasmodium falciparum gp195 expressed by a recombinant baculovirus induces antibodies that completely inhibit parasite growth
26. 19 expressed in S. cerevisiae
27. Identification of T and B cell epitopes recognized by humans in the C-terminal 42-kDa domain of the Plasmodium falciparum merozoite surface protein (MSP)-1
28. Characterization of human T- and B-cell epitopes in the C terminus of Plasmodium falciparum merozoite surface protein 1: Evidence for poor T-cell-recognition of polypeptides with numerous disulfide bonds
29. Towards a blood-stage vaccine for malaria: Are we following all the leads?
30. A cryptic T cell epitope on the apical membrane antigen 1 of Plasmodium chabaudi adami can prime for an anamnestic antibody response: Implications for malaria vaccine design
31. Passive immunization with antibodies against three distinct epitopes on Plasmodium yoelii merozoite surface protein 1 suppresses parasitemia
32. Vaccines against intracellular infections requiring cellular immunity