Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces

Blood

Volumn 100, Issue 2, 2002, Pages 539-546

  Oliver, Julie A ^a,b   Monroe, Dougald M ^a,b,c   Church, Frank C ^a,b   Roberts, Harold R ^a,b   Hoffman, Maureane ^a,b  

^a DUKE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c 932 Mary Ellen Jones Bldg   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5A; BLOOD CLOTTING FACTOR 8A; PROTEIN C; PROTEIN S; THROMBIN;

ARTICLE; BLOOD CLOTTING; CONCENTRATION RESPONSE; ENDOTHELIUM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LIPID VESICLE; MONOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; THROMBOCYTE MEMBRANE; THROMBOSIS;

EID: 0037100452     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V100.2.539     Document Type: Article

References (51)

1. Familial protein S deficiency is associated with recurrent thrombosis
2. The clinical spectrum of heterozygous protein C deficiency in a large New England kindred
3. Diagnosis and treatment of homozygous protein C deficiency. Report of the Working Party on Homozygous Protein C Deficiency of the Subcommittee on Protein C and Protein S, International Committee on Thrombosis and Haemostasis
4. Neonatal purpura fulminans due to homozygous protein C or protein S deficiencies
5. Markers of procoagulant imbalance in patients with inherited thrombophilic syndromes
6. Protein S the regulation of activated protein C
7. Activated protein C-catalyzed inactivation of human factor VIII and VIIIa
8. The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C
9. Protein S binding to human endothelial cells is required for expression of cofactor activity for activated protein C
10. Mutation in blood coagulation factor V associated with resistance to activated protein C
11. Factor protein S as synergistic cofactors to activated protein C in degredation of factor VIIIa
12. Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis
13. Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C
14. Activated protein C resistance: Molecular mechanisms
15. The mechanism of inactivation of human platelet factor Va from normal and activated protein C-resistant individuals
16. Influence of plasma platelets on activated protein C resistance assay
17. Effect of platelet phospholipid exposure on activated protein C resistance: Implications for thrombophilia screening
18. Protein C activation and factor Va inactivation on human umbilical vein endothelial cells
19. Inhibitory mechanism of the protein C pathway on tissue factor-induced thrombin generation: Synergistic effect in combination with tissue factor pathway inhibitor
20. Platelet-derived factor Va/Va Leiden cofactor activities are sustained on the surface of activated platelets despite the presence of activated protein C
21. Regulation of platelet factor Va-dependent thrombin generation by activated protein C at the surface of collagen-adherent platelets
22. Monocytes, but not endothelial cells, downregulate the anticoagulant activity of activated protein C
23. A rapid method for isolation of platelets from human blood by density gradient centrifugation
24. The interaction of human factor VIIa with tissue factor
25. Factors IXa and Xa play distinct roles in tissue factor-dependent initiation of coagulation
26. Production of large unilamellar vesicles by a rapid extrusion procedure: Characterization of size distribution, trapped volume and ability to maintain a membrane potential
27. Vesicles of variable sizes produced by a rapid extrusion procedure
28. Purification of prothrombin on a copper chelate column
29. Rapid sulfopropyl-disk chromatographic purification of bovine and human thrombin
30. Characterization of the defect in activation of factor IX Chapel Hill by human factor XIa
31. Reactive site peptide similarity between heparin cofactor II and antithrombin III
32. Inhibition of thrombin generation by the zymogen factor VII: Implications for the treatment of hemophilia A by factor VIIa
33. Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C
34. Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C
35. Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor
36. Human coagulation factor V is activated to the functional cofactor by elastase and cathepsin G expressed at the monocyte surface
37. Transmission of a procoagulant signal from tissue factorbearing cell to platelets
38. Cultured bovine aortic endothelial cells promote activated protein C-protein C-mediated inactivation of factor Va
39. A cell-based model of hemostasis
40. Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va
41. Studies of the capacity of factor Xa to protect factor Va from inactivation by activated protein C
42. A coagulation pathway on bovine aortic segments leading to generation of factor Xa and thrombin
43. The immunological localization of factor V in human tissue
44. Factor V in human vascular endothelium and in endothelial cells in culture
45. Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator
46. The thrombomodulin/protein C/protein S anticoagulant pathway modulates the thrombogenic properties of the normal resting and stimulated endothelium
47. Formation of factor Va by atherosclerotic rabbit aorta mediates factor Xa-catalyzed prothrombin activation
48. A different view of thrombosis
49. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates
50. Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C
51. Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C pathway