Alternative confidence intervals for the assessment of bioequivalence in four-period cross-over designs

Statistics in Medicine

Volumn 21, Issue 13, 2002, Pages 1825-1847

  Quiroz, Jorge ^a   Ting, Naitee ^a   Wei, Greg C G ^a   Burdick, Richard K ^b  

^a PFIZER INC   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Mixed model; Variance components

Indexed keywords

GENERIC DRUG;

ARTICLE; BIOEQUIVALENCE; COMPUTER SIMULATION; CONFIDENCE INTERVAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG APPROVAL; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG INDUSTRY; FOOD AND DRUG ADMINISTRATION; HUMAN; METHODOLOGY; UNITED STATES;

COMPUTER SIMULATION; CONFIDENCE INTERVALS; CROSS-OVER STUDIES; DRUGS, GENERIC; HUMANS; RANDOMIZED CONTROLLED TRIALS; THERAPEUTIC EQUIVALENCY; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 0037100219     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.1151     Document Type: Article

References (13)

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6. 2- and F-distributions and their applications
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9. An approximate distribution of estimates of variance components
10. 3
11. Confidence intervals on linear combinations of variance components that are unrestricted in sign
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13. Testing a linear relation among variances