GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat

Biochemical Pharmacology

Volumn 64, Issue 2, 2002, Pages 327-337

  Mazzon, Emanuela ^a   Dugo, Laura ^a   Li, Jia He ^b   Di Paola, Rosanna ^a   Genovese, Tiziana ^a   Caputi, Achille P ^a   Zhang, Jie ^b   Cuzzocrea, Salvatore ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Bowel disease; Free radicals; GPI 6150; Inflammation; Nitric oxide; Poly (ADP ribose) synthethase

Indexed keywords

1,11B DIHYDRO[2H]BENZOPYRANO[4,3,2 DE]ISOQUINOLIN 3 ONE; ENZYME INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; MALONALDEHYDE; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITROBENZENE DERIVATIVE; PADGEM PROTEIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON INJURY; COLON MUCOSA; CONTROLLED STUDY; DIARRHEA; DRUG EFFECT; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; WEIGHT REDUCTION;

ANIMALS; BENZENESULFONATES; BENZOPYRANS; BODY WEIGHT; COLITIS; COLON; CYTOKINES; DRUG INTERACTIONS; ISOQUINOLINES; MALE; NEUTROPHIL INFILTRATION; PEROXIDASE; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037099301     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01075-4     Document Type: Article

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