Alternative splicing modulates the frequency-dependent response of CaMKII to Ca2+ oscillations

EMBO Journal

Volumn 21, Issue 14, 2002, Pages 3590-3597

  Bayer, K Ulrich ^a   Koninck, Paul De ^b   Schulman, Howard ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTRE DE RECHERCHE DE L INSTITUT UNIVERSITAIRE EN SANTÉ MENTALE DE QUÉBEC   (Canada)

Author keywords

Alternative splicing; Calcium oscillation; CaMKII; Frequency

Indexed keywords

PROTEIN KINASE (CALCIUM,CALMODULIN) II;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CALCIUM SIGNALING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; HIPPOCAMPUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BRAIN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CLONING, MOLECULAR; COS CELLS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION;

ANIMALIA;

EID: 0037099208     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf360     Document Type: Article

References (45)

1. Regulation of signal transduction by protein targeting: The case for CaMKII
2. 2+/calmodulin-dependent kinase II α isoform gene in skeletal muscle
3. αKAP is an anchoring protein for a novel CaM kinase II isoform in skeletal muscle
4. Developmental expression of the CaM kinase II isoforms: Ubiquitous and δ-CAM kinase II are the early isoforms and most abundant in the developing nervous system
5. Interaction with the NMDA receptor locks CaMKII in an active conformation
6. The versatility and universality of calcium signalling
7. 2+ signals
8. 2+/calmodulin-dependent protein kinase II
9. 2+/calmodulin-dependent protein kinase isoforms in rat brain
10. Functional implications of the subunit composition of neuronal CaM kinase II
11. 2+ oscillations
12. A molecular mechanism for metaplasticity
13. A mechanism for synaptic frequency detection through autophosphorylation of CaM kinase II
14. Glutamate-induced transient modification of the postsynaptic density
15. Glutamate receptors regulate actin-based plasticity in dendritic spines
16. 2+ transients
17. 2+/ calmodulin-dependent protein kinase II. A role for the variable domain in activation
18. Alternative splicing of Drosophila calcium/calmodulin-dependent protein kinase II regulates substrate specificity and activation
19. Phosphorylation modulates the function of the calcium release channel of sarcoplasmic reticulum from cardiac muscle
20. Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals
21. 2+/calmodulin-dependent protein kinase. Characterization of optimal conditions for calcium pump phosphorylation
22. 2+/calmodulin-dependent protein kinase II: The role of structure and autoregulation in cellular function
23. 2+/calmodulin-dependent protein kinase II revealed by electron microscopy
24. 2+/calmodulindependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant
25. Biochemical and immunochemical evidence that the 'major postsynaptic density protein' is a subunit of a calmodulin-dependent protein kinase
26. Calcium dynamics associated with action potentials in single nerve terminals of pyramidal cells in layer 2/3 of the young rat neocortex
27. Three-dimensional reconstructions of calcium/calmodulin-dependent (CaM) kinase II α and truncated CaM kinase II α reveal a unique organization for its structural core and functional domains
28. Long-term potentiation-a decade of progress?
29. CaMKII regulates the frequency response function of hippocampal synapses for the production of both LTD and LTP
30. Calmodulin trapping by calcium-calmodulin-dependent protein kinase
31. 2+/calmodulin-dependent protein kinase in cultures of postnatal rat hippocampal slices
32. 2+/calmodulin-dependent protein kinase binds to actin filaments in a calmodulin-sensitive manner
33. 2+/calmodulin-dependent protein kinase II
34. Calcium/calmodulin-dependent protein kinases
35. Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation
36. CaMKIIβ functions as an F-actin targeting module that localizes CaMKIIα/β heterooligomers to dendritic spines
37. Alternative pre-mRNA splicing: The logic of combinatorial control
38. 2+/calmodulin-dependent protein kinase II
39. Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus
40. A novel pancreatic β-cell isoform of calcium/calmodulin-dependent protein kinase II (b3 isoform) contains a proline-rich tandem repeat in the association domain
41. Inactivation of the sarcoplasmic reticulum calcium channel by protein kinase
42. Phospholamban phosphorylation in intact ventricles
43. Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity
44. Stabilization of dendritic arbor structure in vivo by CaMKII
45. 2+/calmodulin-dependent protein kinase