Polymorphism of the CNS active drug Org 13011: The application of high temperature analysis to detect new polymorphs

International Journal of Pharmaceutics

Volumn 238, Issue 1-2, 2002, Pages 215-228

  Van Hoof, P ^a   Lammers, R ^b   V Puijenbroek, R ^b   Schans, M ^a   Carlier, P ^c   Kellenbach, E ^c  

^a Analytical Chemistry for Development   (Netherlands)

^b AKZO NOBEL CENTRAL RESEARCH   (Netherlands)

^c Process Chemistry   (France)

Author keywords

CNS active drug; Crystallisation; High temperature analysis; Polymorphism; Solid state NMR; X ray powder diffraction

Indexed keywords

1 [4 [4 [4 (TRIFLUOROMETHYL) 2 PYRIDINYL] 1 PIPERAZINYL]BUTYL 2 PYRROLIDINONE 2 BUTENEDIOATE; 2 PYRROLIDONE DERIVATIVE; ORG 13011; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; COOLING; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG DETERMINATION; DRUG FORMULATION; HIGH TEMPERATURE PROCEDURES; NUCLEAR MAGNETIC RESONANCE; PHASE TRANSITION; PRIORITY JOURNAL; RAMAN SPECTROMETRY; THERMAL ANALYSIS; X RAY POWDER DIFFRACTION;

CENTRAL NERVOUS SYSTEM AGENTS; CRYSTALLIZATION; DIFFERENTIAL THERMAL ANALYSIS; HEAT; ISOMERISM; MAGNETIC RESONANCE SPECTROSCOPY; PIPERAZINES; PYRROLES; SPECTRUM ANALYSIS, RAMAN; TEMPERATURE; X-RAY DIFFRACTION;

EID: 0037093770     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00073-X     Document Type: Article

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