Preclinical assessment of anti-CD40 Mab 5D12 in cynomolgus monkeys

Toxicology

Volumn 174, Issue 1, 2002, Pages 53-65

  Boon, Louis ^a,d   Laman, Jon D ^b   Ortiz Buijsse, Antonio ^a   Den Hartog, Marcel T ^a   Hoffenberg, Simon ^c   Liu, Patrick ^c   Shiau, Fred ^c   De Boer, Mark ^a  

^a Tanox Pharma BV   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c Tanox Biosystems Inc   (United States)

^d Macrozyme BV   (Netherlands)

Author keywords

Autoimmunity; CD40; Costimulation; Preclinical safety

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5D12; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CROSS REACTION; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MONKEY; MONOCYTE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; AUTOIMMUNITY; BRAIN CHEMISTRY; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; MACACA FASCICULARIS; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SPECIES SPECIFICITY;

ANIMALIA; MACACA FASCICULARIS; MARMOSETS; MURINAE;

EID: 0037093613     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00057-4     Document Type: Article

References (33)

1. CD40 expression by monocytes: Regulation by cytokines and activation of monocytes by the ligand for CD40
2. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome
3. The CD40 antigen and its ligand
4. Prevention of experimental autoimmune encepyhalomyelitis in the common marmoset (Callithrix jacchus) using a chimeric antagoinist monoclonal antibody against human CD40 is associated with altered B cell responses
5. CD40 ligand and its role in X-linked hyper-IgM syndrome
6. CD40 preferentially costimulates activation of CD4+ T lymphocytes
7. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
8. Generation of monoclonal antibodies to human lymphocyte cell surface antigens using insect cells expressing recombinant proteins
9. Immune regulation by CD40 and its ligand gp39
10. A central role of CD40 ligand in the regulation of CD4(+) T-cell responses
11. CD40 and CD154 in cell-mediated immunity
12. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
13. Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti-mouse CD40 antibodies
14. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
15. CD40 ligand-positive CD8+ T cell clones allow B cell growth and differentiation
16. Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction
17. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154
18. Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154
19. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes
20. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
21. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
22. Helper effector function of human T cells stimulated by anti-CD3 Mab can be enhanced by co-stimulatory signals and is partially dependent on CD40-CD40 ligand interaction
23. Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus)
24. Clinical spectrum of X-linked hyper-IgM syndrome
25. Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP (CD40-ligand) and TNF-α, but strongly enhanced by interleukin-10
26. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
27. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction
28. Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice
29. A new primate model for multiple sclerosis in the common marmoset
30. Functions of CD40 on B cells, dendritic cells and other cells
31. CD40-CD40 ligand
32. IFN-gamma and 1,25(OH)2D3 induce on THP-1 cells distinct patterns of cell surface antigen expression, cytokine production, and responsiveness to contact with activated T cells
33. Mice deficient for the CD40 ligand