Low-affinity CCK-1 receptors inhibit bombesin-stimulated secretion in rat pancreatic acini—Implication of the actin cytoskeleton

Regulatory Peptides

Volumn 105, Issue 2, 2002, Pages 131-137

  Kiehne, Karlheinz ^a   Herzig, Karl Heinz ^a   Otte, Jan M ^a   Fölsch, Ulrich R ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Enzyme secretion; p125 Focal adhesion kinase; Signal transduction

Indexed keywords

ACTIN; AMYLASE; BOMBESIN; BOMBESIN RECEPTOR; CALCIUM ION; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ RECEPTOR; FOCAL ADHESION KINASE; N TERT BUTYLOXYCARBONYLCHOLECYSTOKININ[27-32][28,31 NORLEUCINE] PHENETHYL ESTER; PANCREAS ENZYME; PROTEIN; PROTEIN P125; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ACINAR CELL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSKELETON; ENZYME RELEASE; NONHUMAN; PANCREAS SECRETION; PRIORITY JOURNAL; PROTEIN BINDING; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ACTINS; AMYLASES; ANIMALS; BOMBESIN; CALCIUM; CHOLECYSTOKININ; CULTURE TECHNIQUES; CYTOSKELETON; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GASTRIN-RELEASING PEPTIDE; INTRACELLULAR FLUID; PANCREAS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RATS; RATS, WISTAR; RECEPTOR, CHOLECYSTOKININ A; RECEPTORS, CHOLECYSTOKININ; SINCALIDE; TYROSINE;

MAMMALIA;

EID: 0037093552     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(02)00015-0     Document Type: Article

References (26)

1. Intracellular signalling mechanisms activated by cholecystokinin-regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells
2. Stimulus-secretion coupling in the pancreatic acinus
3. Effects of cholecystokinin (CCK) and other secretagogues on isoforms of protein kinase C (PKC) in pancreatic acini
4. Cellular distribution of isoforms of protein kinase C (PKC) in pancreatic acini
5. Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini
6. Activation of MAP kinase kinase (MEK) and ras by cholecystokinin in rat pancreatic acini
7. FAK focal adhesion kinase and paxillin in rat pancreatic acini
8. Regulation of the actin cytoskeleton by p125 focal adhesion kinase in rat pancreatic acinar cells
9. Cholecystokinin-induced desensitization in dispersed acini from guinea pig
10. Binding of cholecystokinin to high affinity receptors on isolated rat pancreatic acini
11. Cholecystokinin receptors
12. Intracellular mediators of bombesin action on rat pancreatic acinar cells
13. Mammalian bombesin receptors are coupled to multiple signal transduction pathways in pancreatic acini
14. 2+ indicators with greatly improved fluorescence properties
15. Cholecystokinin-induced restricted stimulation of pancreatic enzyme secretion
16. Multiple kinases phosphorylate the pancreatic cholecystokinin receptor in an agonist-dependent manner
17. Agonist-regulated phosphorylation of the pancreatic cholecystokinin receptor
18. Kinetics of binding of cholecystokinin to pancreatic acini
19. Insulation of a G protein-coupled receptor on the plasmalemmal surface of the pancreatic acinar cell
20. Regulation of bombesin receptors on pancreatic acini by cholecystokinin
21. Role of free cytosolic calcium in secretagogue-stimulated amylase release from dispersed acini from guinea pig pancreas
22. Intracellular regulatory mechanisms in pancreatic acinar cellular function
23. Differential inhibitory effects of serine/threonine phosphatase inhibitors and a calmodulin antagonist on phosphoinositol/calcium- and cyclic adenosine monophosphate-mediated pancreatic amylase secretion
24. The subapical actin cytoskeleton regulates secretion and membrane retrieval in pancreatic acinar cells
25. Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells
26. Agonist-induced changes in cell shape during regulated secretion in rat pancreatic acini