Stem cell factor activates telomerase in mouse mitotic spermatogonia and in primordial germ cells

Journal of Cell Science

Volumn 115, Issue 8, 2002, Pages 1643-1649

  Dolci, Sussanna ^a   Levati, Lauretta ^a   Pellegrini, Manuela ^a   Faraoni, Isabella ^a   Graziani, Grazia ^a   Di Carlo, Anna ^a   Geremia, Raffaele ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Germ cells; Kit; Kitl; Meiosis; PI3K; Proliferation; Telomerase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; STEM CELL FACTOR; TELOMERASE; PHOSPHATIDYLINOSITOL 3 KINASE; RNA; TELOMERASE RNA;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBUNIT; MITOSIS; MITOSIS INHIBITION; MOUSE; NONHUMAN; OOCYTE; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPERMATOGONIUM; ANIMAL; CYTOLOGY; DRUG ANTAGONISM; FEMALE; GENETICS; GERM CELL; IN SITU HYBRIDIZATION; MALE; METABOLISM; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMAL; FEMALE; GERM CELLS; IN SITU HYBRIDIZATION; MALE; MICE; MITOSIS; OOCYTES; RNA; RNA, MESSENGER; SPERMATOGONIA; STEM CELL FACTOR; SUPPORT, NON-U.S. GOV'T; TELOMERASE; ANIMALS;

EID: 0037093043     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Telomere length predicts replicative capacity of human fibroblasts
2. Structure and function of telomeres
3. Functional characterization and developmental regulation of mouse telomerase RNA
4. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
5. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility
6. Isolation of mouse primordial germ cells
7. Effect of stem cell factor and granulocyte macrophage-colony stimulating factor on survival of porcine type A spermatogonia cultured in KSOM
8. Requirement for mast cell growth factor for primordial germ cell survival in culture
9. Signaling through extracellular signal-regulated kinase is required for spermatogonial proliferative response to stem cell factor
10. Telomerase activity in female and male rat germ cells undergoing meiosis and in early embryos
11. Stem cell factor/kit upregulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia
12. Effects of the Steel gene product on mouse primordial germ cells in culture
13. Telomerase reverse transcriptase gene is a direct target of c-myc but is not functionally equivalent in cellular transformation
14. Telomere length regulation
15. Fibroblast growth factor 2 up regulates telomerase activity in neural precursor cells
16. Telomere loss: Mitotic clock or genetic time bomb?
17. Activation of telomerase in human lymphocytes and hematopoietic progenior cells
18. Telomerase activity is induced in human periferal B lymphocytes by the stimulation to antigen receptor
19. Hormonal regulation of the ligand for kit in the rat ovary and its effects on spontaneous oocyte meiotic maturation
20. Developmental regulation of the thyroid hormone receptor mRNA expression in rat testis
21. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
22. Specific association of human telomerase activity with immortal cells and cancer
23. Telomere structure and telomerase expression during mouse development and tumorigenesis
24. Point mutation in Kit receptor tyrosine kinase reveals essential roles for kit signaling in oogenesis and spermatogenesis without affecting other kit responses
25. Essential role of mouse telomerase in highly proliferative organs
26. Studies on mouse germ cells inside and outside the gonad
27. Gonadal expression of c-kit encoded at the W locus of the mouse
28. The expression pattern of the c-kit ligand in gonads of mice supports a role for the c-kit receptor in oocyte growth and in proliferation of spermatogonia
29. Cellular composition of fractions of mouse testis cells following velocity sedimentation separation
30. Enhanced detection of human telomerase activity
31. Kit ligand mediates survival of type A spermatogonia and dividing spermatocytes in postnatal mouse testis
32. Detection of telomerase activity in human cells and tumors by telomeric repeat amplification protocol (TRAP)
33. Loss of telomerase activity during male germ cell differentiation
34. Follicle-stimulating hormone induction of Steel Factor (SLF) mRNA in mouse Sertoli cells and stimulation of DNA synthesis in spermatogonia by soluble SLF
35. Glial cell line-derived neutrotrophic factor and neurturin can act as paracrine growth factors stimulating DNA synthesis of Ret-expressing spermatogonia
36. Telomerase activity in human germline and embryonic tissues and cells
37. Direct activation of TERT transcription by c-MYC
38. Myc activates telomerase
39. Telomerase activity in candidate stem cells from fetal liver and adult bone marrow