Dapsone-induced cholestasis and impairment of bile salt output in the rat

Biochemical Pharmacology

Volumn 63, Issue 8, 2002, Pages 1553-1563

  Veggi, Luis M ^a   Crocenzi, Fernando A ^a   Roma, Marcelo G ^a   Dawson, Paul A ^b   Pellegrino, José M ^a   Sánchez Pozzi, Enrique J ^a   Mottino, Aldo D ^a  

^a Inst de Fisiología Exp   (Argentina)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

ASBT; Bile salt metabolism; Bile salt pool; Bile salt secretion; Cholestasis; Dapsone

Indexed keywords

BILE SALT; CYTOCHROME P450 3A; DAPSONE; TAUROURSODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE FLOW; BILE SECRETION; BRUSH BORDER; CHOLESTASIS; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; FEMALE; ILEUM; INTESTINE ABSORPTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; RAT; SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BILE ACIDS AND SALTS; BIOLOGICAL MARKERS; BODY WEIGHT; CARRIER PROTEINS; CHOLESTASIS; DAPSONE; DISEASE MODELS, ANIMAL; FEMALE; LIVER; METHEMOGLOBINEMIA; MICROVILLI; ORGAN SIZE; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; RATS; RATS, WISTAR; SYMPORTERS; TAUROCHOLIC ACID;

EID: 0037090870     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00900-0     Document Type: Article

References (48)

1. Patient treatment compliance in leprosy; A critical review
2. Malaria chemoprophylaxis using proguanil/dapsone combinations on the Thai-Cambodian border
3. Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection
4. Pharmacokinetic observations on dapsone in dermatitis herpetiformis
5. Inhibition of neutrophil adherence to antibody by dapsone: A possible therapeutic mechanism of dapsone in the treatment of IgA dermatoses
6. N-hydroxylation of 4,4′-diaminodiphenylsulphone (Dapsone) by liver microsomes, and in dogs and humans
7. Metabolism of dapsone to a hydroxylamine by human neutrophils and mononuclear cells
8. Dapsone: Modes of action, toxicity and possible strategies for increasing patient tolerance
9. Dapsone induced hemolytic anemia
10. The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients
11. Sex-dependent sensitivity to dapsone-induced methaemoglobinemia in the rat
12. Oral therapy for Pneumocystis carinii in the acquired imumunodeficiency syndrome - A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone
13. Liver involvement in the sulfone syndrome
14. Physicochemical properties of bile acids and their relationship to biological properties: An overview of the problem
15. Membrane fluidity and bile salt damage
16. Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes
17. Induction of sodium-dependent bile acid transporter messenger RNA, protein and activity in rat ileum by cholic acid
18. Nature of bile acid maximum secretory rate in the rat
19. Adaptive regulation of hepatic bile salt transport. Effect of prolonged bile salt depletion in the rat
20. Effects of ethinylestradiol and phenobarbital on bile acid synthesis and biliary bile acid and cholesterol excretion
21. Enhancement of intestinal UDP-glucuronosyltransferase activity in partially hepatectomized rats
22. Expression and localization of multidrug resistant protein mrp2 in rat small intestine
23. A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Their use in investigating some properties of D-glucose and choline transport systems
24. Protein measurement with the Folin phenol reagent
25. Enzymatic analysis of steroid hormones
26. Development and validation of a method for measuring the glycine and taurine conjugates of bile acids in bile by high-performance liquid chromatography
27. Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions
28. Microdetermination of oxyhemoglobin, methemoglobin and sulfhemoglobin in a single sample of blood
29. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
30. Premicellar taurocholate enhances calcium uptake from all regions of rat small intestine
31. Efficacy of diaminodiphenylsulfone and other drugs in murine Pneumocystis carinii pneumonitis
32. Bile acids modify alkaline phosphatase induction and bile secretion pressure after bile duct obstruction in the rat
33. Mechanisms and regulation of bile secretion
34. Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter
35. Hepatic synthesis of bile acids. Biochemical steps and mechanisms of rate control
36. Regulation of bile acid synthesis
37. Bile acids
38. Gonadal influence on the metabolism and haematological toxicity of dapsone in the rat
39. Evidence that the biotransformation of dapsone and monoacetyldapsone to their respective hydroxylamine metabolites in rat liver microsomes is mediated by cytochrome P450 2C6/2C11 and 3A1
40. The molecular biology of cytochrome P450s
41. Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites
42. Role of dapsone hydroxylamine in dapsone-induced hemolytic anemia
43. Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro. IV: Implications for the development of agranulocytosis
44. Haemolysis by diphenylsulfones: Comparative effects of DDS and hydroxylamine-DDS
45. Characterization of rat and human liver cytochrome P450 forms involved in nifedipine oxidation. A prototype for genetic polymorphism in oxidative drug metabolism
46. Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4
47. CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone
48. Effects of ketoconazole on the erythromycin breath test and the dapsone recovery ratio