VDAC and the bacterial porin PorB of Neisseria gonorrhoeae share mitochondrial import pathways

EMBO Journal

Volumn 21, Issue 8, 2002, Pages 1916-1929

  Müller, Anne ^a   Rassow, Joachim ^a   Grimm, Jan ^a   Machuy, Nikolaus ^b   Meyer, Thomas F ^c   Rudel, Thomas ^d  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c RESEARCH AND DEVELOPMENT   (Australia)

^d MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

Author keywords

Import pathways; Mitochondria; Neisseria gonorrhoeae; PorB; VDAC

Indexed keywords

ANION CHANNEL; MEMBRANE PROTEIN; PORIN; SIGNAL PEPTIDE;

APOPTOSIS; ARTICLE; BACTERIAL MEMBRANE; CELL DEATH; CELL KILLING; CELL SURVIVAL; GENETIC MANIPULATION; IMPORT DISEASE; MITOCHONDRIAL MEMBRANE; NEISSERIA GONORRHOEAE; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL;

BACTERIAL OUTER MEMBRANE PROTEINS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; GENE EXPRESSION; HELA CELLS; HUMANS; INTRACELLULAR MEMBRANES; ION CHANNELS; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NEISSERIA GONORRHOEAE; PORINS; RECEPTORS, CELL SURFACE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; VOLTAGE-DEPENDENT ANION CHANNELS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; INSERTION SEQUENCES; NEGIBACTERIA; NEISSERIA; NEISSERIA GONORRHOEAE; NEISSERIA MUCOSA;

EID: 0037090477     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.8.1916     Document Type: Article

References (65)

1. Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein
2. CGMla antigen of neutrophils, a receptor of gonococcal opacity proteins
3. Salmonella spp. are cytotoxic for cultured macrophages
4. A bacterial invasin induces macrophage apoptosis by binding directly to ICE
5. Role of the N- and C-termini of porin in import into the outer membrane of Neurospora mitochondria
6. 2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria
7. Role of the carboxy-terminal phenylalanine in the biogenesis of outer membrane protein PhoE of Escherichia coli K-12
8. Identification of phospholipids as new components that assist in the in vitro trimerization of a bacterial pore protein
9. v, integrin receptors
10. An internal targeting signal directing proteins into the mitochondrial intermembrane space
11. Tom5 functionally links mitochondrial preprotein receptors to the general import pore
12. Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex
13. Folding of a bacterial outer membrane protein during passage through the periplasm
14. M11L: A novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes
15. Inhibition of apoptosis in chlamydia-infected cells: Blockade of mitochondrial cytochrome c release and caspase activation
16. Internal targeting signal of the BCS1 protein: A novel mechanism of import into mitochondria
17. Origin of eukaryotic programmed cell-death - A consequence of aerobic metabolism
18. The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release
19. CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes
20. Mitochondria and apoptosis
21. Both amino- and carboxy-terminal portions are required for insertion of yeast porin into the outer mitochondrial membrane
22. Protein sorting to mitochondria: Evolutionary conservations of folding and assembly
23. Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import
24. A splice-isoform of vesicle-associated membrane protein-1 (VAMP-l) contains a mitochondrial targeting signal
25. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore
26. Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein R and Bcl-2
27. Biogenesis of the mitochondrial receptor complex. Two receptors are required for binding of MOM38 to the outer membrane surface
28. Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex
29. Mitochondrial implication in apoptosis - Towards an endosymbiont hypothesis of apoptosis evolution
30. Mitrochondrial control of cell death
31. Phase variation of the opacity outer membrane protein controls invasion by Neisseria gonorrhoeae into human epithelial cells
32. Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis
33. A signal-anchor sequence selective for the mitochondrial outer membrane
34. Anti-apoptotic strategies of lymphotropic viruses
35. Deletion of the receptor MOM19 strongly impairs import of cleavable preproteins into Saccharomyces cerevisiae mitochondria
36. Multistep assembly of the protein import channel of the mitochondrial outer membrane
37. Salmonella typhimurium invasion induces apoptosis in infected macrophages
38. Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death
39. Modification of host cell apoptosis by viral and bacterial pathogens
40. Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases
41. Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells
42. High-affinity binding sites involved in the import of porin into mitochondria
43. Mitochondrial protein import. Bypass of proteinaceous surface receptors can occur with low specificity and efficiency
44. Protein sorting: Recognizing mitochondrial presequences
45. The carboxyl-terminal two-thirds of the ADP/ATP carrier polypeptide contains sufficient information to direct translocation into mitochondria
46. Role of ATP in mitochondrial protein import. Conformational alteration of a precursor protein can substitute for ATP requirement
47. Protein import into mitochondria: ATP-dependent protein translocation activity in a submitochondrial fraction enriched in membrane contact sites and specific proteins
48. Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential
49. Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis
50. Further evidence for multitopological localization of mammalian porin (VDAC) in the plasmalemma forming part of a chloride channel complex affected in cystic fibrosis and encephalomyopathy
51. Interaction of Yersinia enterocolitica with macrophages leads to macrophage cell-death through apoptosis
52. Modulation of Neisseria porin (PorB) by cytosolic ATP/GTP of target cells: Parallels between pathogen accommodation and mitochondrial endosymbiosis
53. Interactions of the human mitochondrial protein import receptor, hTom 20, with the precursor proteins in vitro reveal pleiotropic specificities and different receptor domain requirements
54. Direct membrane insertion of voltage-dependent anion-selective channel protein catalyzed by mitochondrial Tom20
55. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
56. Mitochondrial import of the ADP/ATP carrier protein in Saccharomyces cerevisiae. Sequences required for receptor binding and membrane translocation
57. Lysine residues at positions 234 and 236 in yeast porin are involved in its assembly into the mitochondrial outer membrane
58. MOM19, an import receptor for mitochondrial precursor proteins
59. Gonococcal pilin variants in experimental gonorrhoea
60. The fight of -viruses against apoptosis
61. Targeting of C-terminal (tail)-anchored proteins: Understanding how cytoplasmic activities are anchored to intracellular membranes
62. Fate of the major outer membrane protein P.IA in early and late events of gonococcal infection of epithelial cells
63. The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria
64. The mitochondrial permeability transition
65. Shigella flexneri induces apoptosis in infected macrophages