Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5

Journal of Infectious Diseases

Volumn 185, Issue 8, 2002, Pages 1174-1178

  Yang, Otto O ^a,c   Garcia Zepeda, Eduardo A ^b,d   Walker, Bruce D ^a   Luster, Andrew D ^a,b  

^a Center for AIDS Research   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UCLA MEDICAL CENTER   (United States)

^d UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; LIGAND; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 2; PERTUSSIS TOXIN; RANTES;

ARTICLE; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONTROLLED STUDY; DESENSITIZATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; VIRUS INHIBITION; VIRUS REPLICATION;

CALCIUM; CD4-POSITIVE T-LYMPHOCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HIV-1; HUMANS; MONOCYTE CHEMOATTRACTANT PROTEINS; PERTUSSIS TOXIN; RECEPTORS, CCR5; VIRULENCE FACTORS, BORDETELLA; VIRUS REPLICATION;

EID: 0037090171     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/339678     Document Type: Article

References (14)

1. + T cells
2. HIV entry and tropism: The chemokine receptor connection
3. Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein
4. CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells
5. Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication
6. Sensitivity of human immunodeficiency virus infection to various alpha, beta and gamma chemokines
7. + T-cell clone (PM1): Failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1
8. Ex vivo expansion of CD4 lymphocytes from human immunodeficiency virus type 1-infected persons in the presence of combination antiretroviral agents
9. + cells: Evidence for HLA class I restricted triggering of cytolytic and non-cytolytic mechanisms
10. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3
11. Chemokines - Chemotactic cytokines that mediate inflammation
12. Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3
13. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family
14. Induction of monocyte chemotactic proteins MCP-1 and MCP-2 in human fibroblasts and leukocytes by cytokines and cytokine inducers: Chemical synthesis of MCP-2 and development of a specific RIA