Mutations of Chk2 in primary hematopoietic neoplasms [6]

Blood

Volumn 99, Issue 8, 2002, Pages 3075-3077

  Hangalshi, Akira ^a   Ogawa, Selshi ^a   Qiao, Ying ^a   Wang, Lill ^a   Hosoya, Noriko ^a   Yuji, Koichiro ^a   Imai, Yoichi ^a   Takeuchi, Kengo ^a   Miyawaki, Shuichi ^a   Hirai, Hisamaru ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHK2 KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

CANCER SUSCEPTIBILITY; DNA DAMAGE; FAMILIAL CANCER; GENE MUTATION; HEMATOPOIETIC SYSTEM TUMOR; HUMAN; HUMAN TISSUE; LETTER; LEUKEMIA; LYMPHOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

EID: 0037089408     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.8.3075     Document Type: Letter

References (8)

1. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
2. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
3. Heterozygous germ line hChk2 mutations in Li Fraumeni syndrome
4. Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic Chk2 mutation in small cell lung cancer
5. Mantle cell lymphoma is characterized by inactivation of the ATM gene
6. Atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
7. Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias
8. Cancer-susceptibility genes: Gatekeepers and caretakers