CCAAT/enhancer-binding proteins are required for granulopoiesis independent of their induction of the granulocyte colony-stimulating factor receptor

Blood

Volumn 99, Issue 8, 2002, Pages 2776-2785

  Wang, Qian Fei ^b   Friedman, Alan D ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CYCLOHEXIMIDE; CYTOKINE; DACTINOMYCIN; ESTROGEN RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; LACTOFERRIN; LEUCINE ZIPPER PROTEIN; LYSOZYME; MYELOPEROXIDASE;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA BINDING; GENE CONTROL; GRANULOPOIESIS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; STEM CELL; TRANSACTIVATION;

EID: 0037089322     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.8.2776     Document Type: Article

References (64)

1. The DNA binding domain of the rat liver protein C/EBP is bipartite
2. Regulation of granulopoiesis by transcription factors and cytokine receptors
3. Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene
4. A liver enriched transcriptional activator protein, LAP, and a transcriptional inhibitor, LIP, translated from the same mRNA
5. Translational control of C/EBPalpha and C/EBPbeta isoform expression
6. Identification of transcriptional activation and repression domains of C/EBPε
7. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factor C/EBP and LAP functions as a dominant-negative inhibitor of gene transcription
8. Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators
9. A novel temporal pattern of three C/EBP family members in differentiating myelomonocytic cells
10. NF-M (chicken C/EBPβ) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line
11. CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic differentiation from bipotential myeloid cells
12. PU.1 (Spi-1) and C/EBPα regulate expression of the granulocyte-macrophage colony-stimulating factor receptor α gene
13. A novel human CCAAT/enhancer binding protein gene, C/EBP epsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T cell receptor alpha/delta locus
14. GADD153/CHOP, a DNA damage-inducible protein, reduced CCAAT/enhancer binding protein activities and increased apoptosis in 32D cl3 myeloid cells
15. Absence of G-CSF signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
16. PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
17. Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein α (C/EBPα) is critical for granulopoiesis
18. Lymphoproliferative disorder and imbalanced T-helper response in C/EBPβ-deficient mice
19. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
20. Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene
21. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice
22. The role of C/EBP(epsilon) in the terminal stages of granulocyte differentiation
23. GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts
24. C/EBPβ, when expressed from the C/EBPα gene locus, can functionally replace C/EBPα in liver but not in adipose tissue
25. C/EBPalpha bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts
26. CCAAT/enhancer binding protein ε is a potential retinoid target gene in acute promyelocytic leukemia treatment
27. Multipotent hematopoietic cell lines derived from C/EBPα(-/-) knockout mice display granulocyte macrophage-colony stimulating factor, granulocyte-colony-stimulating factor, and retinoic acid-induced granulocyte differentiation
28. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
29. Regulation of proliferative and differentiative responses in a murine progenitor cell line
30. Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges
31. Production of high-titer helper-free retroviruses by transient transfection
32. Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systems
33. CBFβSMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells
34. CBFβSMMHC, expressed in M4eo AML, reduces p53 induction and slows apoptosis in hematopoietic cells exposed to DNA-damaging agents
35. Kruppel-associated boxes are potent transcriptional repression domains
36. The leucine zipper: A hypothetical structure common to a new class of DNA binding proteins
37. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
38. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
39. CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells
40. Tyrosine-dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration
41. C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter
42. Mouse lysozyme M gene: Isolation, characterization, and expression studies
43. C/EBPε is a myeloid-specific activator of cytokine, chemokine, and macrophage-colony-stimulating factor receptor genes
44. C/EBPα and G-CSF receptor signals cooperate to induce the myeloperoxidase and neutrophil elastase genes
45. Growth and differentiation of human stem cell factor/erythropoietin-dependent erythroid progenitor cells in vitro
46. Transcriptional regulation of two myeloid-specific genes, myeloperoxidase and lactoferrin, during differentiation of the murine cell line 32D cl3
47. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor deficiency, and impaired neutrophil mobilization
48. Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice
49. Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation
50. The far upstream chicken lysozme enhancer at -6.1 kilobase, by interacting with NF-M, mediates lipopolysaccharide-induced expression of the chicken lysozyme gene in chicken myelomonocytic cells
51. Differential activity of the -2.7 kb chicken lysozyme enhancer in macrophages of different ontogenic origins is regulated by C/EBP and PU.1 transcription factors
52. Cloning of the novel human myeloid-cell-specific C/EBP-ε transcription factor
53. Myeloid transcription factor C/EBPepsilon is involved in the positive regulation of lactoferrin gene expression in neutrophils
54. Sp1 and C/EBP are necessary to activate the lactoferrin gene promoter during myeloid differentiation
55. CCAAT/enhancer binding protein gene promoter: Binding of nuclear factors during differentiation of 3T3-L1 preadipocytes
56. Regulation of the myeloperoxidase enhancer binding proteins PU.1, C/EBPαβ, and δ during granulocyte-lineage specification
57. C/EBPα regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice
58. C/EBPα inhibits cell growth via direct repression of E2F-DP-mediated transcription
59. c-Myc is a critical target for C/EBPα in granulopoiesis
60. CCAAT/enhancer-binding protein-α cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding
61. Transcriptional activation of the cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937
62. Only late, nonmitotic stages of granulocyte differentiation in 32Dcl3 cells are blocked by ectopic expression of murine c-myb and its truncated forms
63. Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF: A model for overcoming inhibition of proliferation by CBF oncoproteins
64. Regulation of B lymphocyte and macrophage development by graded expression of PU.1