Identification of significant host factors for HIV dynamics modelled by non-linear mixed-effects models

Statistics in Medicine

Volumn 21, Issue 5, 2002, Pages 753-771

  Wu, Hulin ^a   Wu, Lang ^b  

^a FRONTIER SCIENCE AND TECHNOLOGY RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

AIDS; HIV; HIV dynamics; Missing data; Mixed effects models; Multiple imputation

Indexed keywords

LAMIVUDINE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BAYES THEOREM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HOST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERMETHOD COMPARISON; LINEAR SYSTEM; MAJOR CLINICAL STUDY; RELIABILITY; SIMULATION; STATISTICAL ANALYSIS; STATISTICAL MODEL; STATISTICS; VIRUS LOAD;

ACQUIRED IMMUNODEFICIENCY SYNDROME; BAYES THEOREM; COMPUTER SIMULATION; HIV; HUMANS; LEAST-SQUARES ANALYSIS; MODELS, BIOLOGICAL; PROTEASE INHIBITORS; REVERSE TRANSCRIPTASE INHIBITORS; VIRAL LOAD;

EID: 0037088327     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.1015     Document Type: Article

References (21)

1. Efficacy of drug combination and dosing regimen in antiviral therapy
2. Relationships between antiviral treatment effects and biphasic viral decay rates in modeling HIV dynamics
3. Interpatient variation of viral dynamics in HIV-1 infection: Modeling results of AIDS Clinical Trials Group Protocol 315
4. Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: Relationships to host factors, cellular restoration and virological endpoints
5. Estimation of HIV dynamic parameters
6. Population HIV-1 dynamics in vivo: Applicable models and inferential tools for virological data from AIDS clinical trials
7. Nonlinear Models for Repeated Measurements Data
8. Linear and Nonlinear Models for the Analysis of Repeated Measurements
9. A multiple imputation method for missing covariates in nonlinear mixed-Effect models, with application to HIV dynamics
10. A three-step approach combining Bayesian regression and NONMEM population analysis: Application to midazolam
11. Building population pharmacokinetic-pharmacodynamic models
12. Estimating population kinetics
13. Nonlinear mixed effects models for repeated measures data
14. A note on the use of Laplace's approximation for nonlinear mixed-effect models
15. Methodology of population pharmacokinetics
16. Analysis of Longitudinal Data
17. Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine and ritonavir: Results of AIDS Clinical Trials Group Protocol 315
18. Inference and missing data
19. Assessing antiviral potency of anti-HIV therapies in vivo by comparing viral decay rates in viral dynamic models
20. Immunologic effects of 48 weeks of zidovudine, lamivudine, and ritonavir therapy of HIV infection