Porcine hematopoiesis on primate stroma in long-term cultures: Enhanced growth with neutralizing tumor necrosis factor-α and tumor growth factor-β antibodies

Transplantation

Volumn 73, Issue 5, 2002, Pages 723-731

  Giovino, Maria A ^a   Down, Julian D ^a   Jackson, John D ^a,c   Sykes, Megan ^b   Monroy, Rodney L ^a,d   White Scharf, Mary E ^a  

^a BioTransplant Inc   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d Eligix Inc

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH FACTOR; CYTOKINE; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL GROWTH; COLONY FORMING CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEMATOPOIESIS; IMMUNOLOGICAL TOLERANCE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; STROMA CELL; SWINE;

EID: 0037087532     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200203150-00011     Document Type: Article

References (69)

1. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen
2. Natural killer cells weakly resist engraftment of allogeneic, long-term, multilineage-repopulating hematopoietic stem cells
3. Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance
4. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
5. Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model
6. Mixed chimerism and tolerance without whole body irradiation in a large animal model
7. Mixed allogeneic chimerism and renal allograft tolerance in Cynomolgus monkeys
8. Long-term outcome and alloantibody production in a non-myeloablative regimen for induction of renal allograft tolerance
9. Organ transplantation between widely disparate species
10. Clinical xenotransplantation of solid organs
11. The transplantation of organs and tissues between species 481
12. Xenotransplantation. A review of current issues
13. Specific tolerance induction across a xenogeneic barrier: Production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen
14. Mixed chimerism as an approach to transplantation tolerance
15. Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: A model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier
16. Tolerance induction for xenotransplantation
17. Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption
18. Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specifc growth factors
19. Humoral tolerance in xenogeneic BMT recipients conditioned by a nonmyeloablative regimen
20. Mechanism of tolerance in mixed xenogeneic chimeras prepared with a nonmyeloablative conditioning regimen
21. Evidence for non-immune mechanisms in the loss of hematopoietic chimerism in rat->mouse mixed xenogeneic chimeras
22. Engraftment of rat bone marrow and its role in negative selection of murine T cells in mice conditioned with a non-myeloablative regimen
23. Role of intrathymic rat class II+ cells in maintaining deletional tolerance in xenegenetic rat-
24. Host marrow has a competitive advantage which limits donor hematopoietic repopulation in mixed xenogeneic chimeras
25. The importance of nonimmune factors in reconstitution by discordant xenogeneic hematopoietic cells
26. Donor-specific growth factors promote swine hematopoiesis in SCID mice
27. Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: Toward tolerance induction across discordant xenogeneic barriers
28. Xenogeneic bone marrow transplantation: II. Porcine-specific growth factors enhance porcine bone marrow engraftment in an in vitro primate microenvironment
29. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-beta
30. Constitutive in vivo cytokine and hematopoietic growth factor gene expression in the bone marrow and peripheral blood of healthy individuals
31. Cytokine and chemokine production by CD34+ haemopoietic progenitor cells: Detection in single cells
32. TNF-alpha inhibits the further development of committed progenitors while stimulating multipotential progenitors in mouse long-term bone marrow cultures
33. Growth acceleration and stem cell expansion in Dexter-type cultures by neutralization of TGF-beta
34. TGF-beta and MIP-1 alpha exert their main inhibitory activity on very primitive CD34+2CD38-cells but show opposite effects on more mature CD34+CD38+ human hematopoietic progenitors
35. Comparison of the inhibitory effect of AcSDKP, TNF-alpha, TGF-beta, and MIP-1 alpha on marrow-purified CD34+ progenitors
36. Tumor necrosis factor alpha is a potent synergistic factor for the proliferation of primitive human hematopoietic progenitor cells and induces resistance to transforming growth factor beta but not to interferon gamma
37. Transplantation in miniature swine. I. Fixation of the major histocompatibility complex
38. Transplantation of a hematopoietic stem cell population isolated by counterflow centrifugal elutriation from monkey bone marrow
39. Lymphocsyte depletion of donor bone marrow by counterflow centrifugal elutriation: Results of a phase I clinical trial
40. Xenogeneic bone marrow transplantation: I. Cloning, expression, and species specificity of porcine IL-3 and granulocyte-macrophage colony-stimulating factor
41. Bone marrow transplantation in miniature swine. II. Effect of selective genetic differences on marrow engraftment and recipient survival
42. Cross-species compatibility of intercellular adhesion molecule-1 (CD54) with its ligands
43. Function of porcine adhesion molecules in a human marrow microenvironment
44. Regulation of haemopoietic stem cell proliferation in long term bone marrow cultures
45. Enhancement of swine progenitor chimerism in mixed swine/human bone marrow cultures with swine cytokines
46. Direct contact between human primitive hematopoietic progenitors and bone marrow stroma is not required for long-term in vitro hematopoiesis
47. Soluble factor(s) produced by human bone marrow stroma increase cytokine-induced proliferation and maturation of primitive hematopoietic progenitors while preventing their terminal differentiation
48. Diffusible factors from the murine cell line M2-10B4 support human in vitro hematopoiesis
49. Induction of negative hematopoietic regulators by neurokinin-A in bone marrow stroma
50. Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro
51. Effects of recombinant transforming growth factor-beta 1 on hematologic recovery after treatment of mice with 5-fluorouracil
52. The differential inhibition of hemopoietic growth factor activity by cytotoxins and interferon-gamma
53. Tumor necrosis factor and human hematopoiesis: I. Kinetics and diversity of human bone marrow cell response to recombinant tumor necrosis factor alpha in short-term suspension cultures in vitro
54. Effects of tumor necrosis factor-alpha on normal feline hematopoietic progenitor cells
55. Differential effects of the hematopoietic inhibitors MIP-1 alpha, TGF-beta, and TNF-alpha on cytokine-induced proliferation of subpopulations of CD34+ cells purified from cord blood and fetal liver
56. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer
57. Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha
58. Evidence that residual host cells surviving the conditioning regimen to allogeneic bone marrow transplantation inhibit donor hematopoiesis in vitro-the role of TNF-alpha
59. Differential manipulation of normal and chronic myeloid leukemia stem cell proliferation in vitro
60. Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides
61. TNF-alpha bidirectionally modulates the viability of primitive murine hematopoietic progenitor cells in vitro
62. Tumor necrosis factor-alpha inhibits stem cell factor-induced proliferation of human bone marrow progenitor cells in vitro. Role of p55 and p75 tumor necrosis factor receptors
63. Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+ CD38-) human bone marrow progenitor cells: Distinct and key interactions with the ligands for c-kit and flt3, and inhibitory effects of TGF-beta and TNF-alpha
64. The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta
65. TNF-alpha, the great imitator: Role of p55 and p75 TNF receptors in hematopoiesis
66. Bifunctional effects of tumor necrosis factor alpha (TNF alpha) on the growth of mature and primitive human hematopoietic progenitor cells: Involvement of p55 and p75 TNF receptors
67. Role of the 75-kDa tumor necrosis factor receptor: Inhibition of early hematopoiesis
68. Tumor necrosis factor alpha (TNF alpha) downregulates c-kit proto-oncogene product expression in normal and acute myeloid leukemia CD34+ cells via p55 TNF alpha receptors
69. The growth response of Lin-Thy-1+ hematopoietic progenitors to cytokines is determined by the balance between synergy of multiple stimulators and negative cooperation of multiple inhibitors