Antithrombin and first complement protein recognize the same active heparin fraction

Thrombosis Research

Volumn 105, Issue 6, 2002, Pages 537-541

  Calabrese, Graciela C ^a   Recondo, Eduardo F ^a   Fernandez De Recondo, Marta E ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Antithrombin; C1; Divalent cations; Heparin; Interactions

Indexed keywords

AGAROSE; ANTITHROMBIN; CALCIUM ION; COMPLEMENT; GLYCOSAMINOGLYCAN; HEPARIN; PENTASACCHARIDE; RESIN; SODIUM CHLORIDE; ANTICOAGULANT AGENT; ANTITHROMBIN III; CALCIUM; COMPLEMENT COMPONENT C1;

ANTICOAGULATION; ARTICLE; BINDING AFFINITY; COMPLEMENT SYSTEM; COMPLEX FORMATION; IONIC STRENGTH; PRIORITY JOURNAL; PROTEIN BINDING; AFFINITY CHROMATOGRAPHY; BINDING SITE; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; OSMOLARITY; PRECIPITATION;

ANTICOAGULANTS; ANTITHROMBIN III; BINDING SITES; CALCIUM; CHROMATOGRAPHY, AFFINITY; COMPLEMENT 1; HEPARIN; HUMAN; OSMOLAR CONCENTRATION; PRECIPITATION; PROTEIN BINDING; SUPPORT, NON-U.S. GOV'T; COMPLEMENT C1; HUMANS;

EID: 0037085706     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(02)00062-2     Document Type: Article

References (15)

1. The binding properties of human complement component C1q: Interaction with mucopolysaccharides
2. Structural determinants of the capacity of heparin to inhibit the formation of the human amplification C3 convertase
3. Structure function relationships in the inhibitory effect of heparin on complement activation: Independency of the anticoagulant and anticomplementary sites on the heparin molecule
4. Complement inhibitory and anticoagulant activities of fractionated heparins
5. Heparin and Concanavalin A interaction: Isolation of a fraction with higher anticoagulant activity
6. Heparin and Concanavalin A interaction as a model for studying the mechanism of the anticoagulant activity
7. Interaction of Concanavalin A with a fraction of dermatan sulphate containing a very high anticoagulant activity
8. The first component of the human complement system recognizes the active fraction of heparin
9. An active fraction of unfractionated heparin from a natural source is recognized by the first component of the complement system
10. Purification of the first component of human complement by affinity chromatography on human gamma globulin linked to Sepharose
11. Nature of active site of a subunit of the first component of human complement
12. Low molecular weight heparin therapy: Is monitoring needed?
13. The complement system
14. Can the haemorrhagic component of heparin be identified? Or an attempt at clean thinking on a dirty drug
15. New class of heparin derivates with a potent antithrombotic effect and a very limited hemorrhagic activity